Chitosan Microparticles Prepared by the Water-in-Oil Emulsion Solvent Diffusion Method for Drug Delivery

Phromsopha, Theeraphol; Baimark, Yodthong

doi:10.3923/biotech.2010.61.66

Cited by 20 publications

(17 citation statements)

References 14 publications

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“…Chitosan microspheres as delivery drug carriers can be prepared by the water-in-oil emulsion solvent diffusion method, being ethyl acetate the oil phase. Figure 2 displays Scanning Electron Microscopy (SEM) image of the chitosan microspheres with drug entrapment (Phromsopha & Baimark, 2010). Chitosan has been largely employed in many areas, such as photography, biotechnology, cosmetics, food processing, biomedical products (artificial skin, wound dressing, contact lens, etc.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Properties of Chitosan

Alvarenga¹

2011

Biotechnology of Biopolymers

124

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Section: Introductionmentioning

confidence: 99%

Characterization and Properties of Chitosan

Alvarenga¹

2011

Biotechnology of Biopolymers

124

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“…This results in retardation in diffusivity of monomer molecules from solution phase into the fiber phase. 27 Therefore percent grafting is observed to decrease beyond 0.10 M concentration of HNO 3.…”

Section: Resultsmentioning

confidence: 93%

“…Gentamycin sulfate (GS) is a water soluble drug with a fair solubility of about 50 mg/mL water. 27 In aqueous medium it is present in the form of cation. The poly(acrylic acid)‐grafted‐fibers have carboxylic groups attached along the polyacrylic acid grafted chains with free or counter H + ions.…”

Section: Resultsmentioning

confidence: 99%

Gentamicin‐loaded poly(acrylic acid)‐grafted cotton fibers, part 1: Synthesis, characterization, and preliminary drug release study

Bajpai¹,

Das²

2011

J of Applied Polymer Sci

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This study describes preparation of poly (acrylic acid)-grafted cotton fibers and release of antibiotic drug gentamicin sulfate from them under physiological conditions. Poly(acrylic acid) has been grafted onto cellulose backbone of cotton fibers via Ce(IV)-initiated polymerization in aqueous medium. The conditions obtained for optimum grafting were as follows: initiation time 30 min; initiation temperature 37 C; monomer concentration 27.8 mM; grafting temperature 30 C; nitric acid (catalyst) concentration 0.1M. The grafted fibers were characterized by FTIR, TGA, and SEM analysis. The antibiotic drug gentamicin sulfate (GS) was loaded into the grafted fibers by equilibration method and release was studied under physiological conditions. The kinetic release data was interpreted by first-order kinetic model. Finally, drug-loaded fibers showed fair antibacterial action against Escherichia coli.

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“…In our previous works, a water-in-oil (W/O) emulsion solvent diffusion method has been used to produce hydrophilic polymer-based microspheres containing porous matrices of chitosan [1517], silk fibroin [18] and starch [19]. The proposed mechanism of the W/O emulsion solvent diffusion method is presented in Scheme.…”

Section: Resultsmentioning

confidence: 99%