Chitosan microspheres in PLG films as devices for cytarabine release

Blanco, Marcos; Gómez, Clara; Olmo, Rosa; Muñiz, E; Teijón, José M.

doi:10.1016/s0378-5173(00)00408-7

Cited by 61 publications

(25 citation statements)

References 12 publications

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“…In similar studies, chitosan microspheres were not degraded by the enzyme for up to 20 days. 10 The primary mechanisms for release of drugs from matrix systems in vitro are swelling, diffusion, and disintegration, 26 while in vivo release is governed by both diffusion and biodegradation of matrix. Tomihata and Ikada 27 reported that the in vitro and in vivo degradation of chitosan films prepared by solution casting method occurred less rapidly as the degree of deacetylation increased, and films that were greater than 73% deacetylated showed slower biodegradation.…”

Section: Discussionmentioning

confidence: 99%

“…6 Further, gels and films of chitosan have been used for oral delivery of chlorhexidine digluconate in the treatment of fungal infections. 7 In addition, chitosan has been extensively evaluated as a carrier of various antineoplastic agents such as 5-fluorouracil, 8 mitoxantrone, 9 cytarabine, 10 and paclitaxel. 11 The film-forming property of chitosan has found many applications in tissue engineering and drug delivery by virtue of its mechanical strength and rather slow biodegradation.…”

Section: Introductionmentioning

confidence: 99%

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Development and characterization of biodegradable chitosan films for local delivery of paclitaxel

Dhanikula

Panchagnula

2004

AAPS J

103

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Intratumoral and local drug delivery strategies have gained momentum recently as a promising modality in cancer therapy. In order to deliver paclitaxel at the tumor site in therapeutically relevant concentrations, chitosan films were fabricated. Paclitaxel could be loaded at 31% wt/wt in films, which were translucent and flexible. Physicochemical characterization of paclitaxel via thermal, spectroscopic, x-ray diffraction, and electron microscopy techniques revealed information on solid-state properties of paclitaxel as well as chitosan in films. While chitosan was in amorphous form, paclitaxel seemed to be present in both amorphous and crystalline forms in film. The polymeric dispersion of paclitaxel in poloxamer formed fibrous structures generating discontinuities in the film matrix, thereby leading to the introduction of perturbations in the packing arrangement of polymer chains. These films released only 10% to 15% of loaded paclitaxel by a burst effect under in vitro testing conditions, with lysozyme having no effect on the release. However, films softened after implantation in mice and lost integrity over time. The implantable delivery system is not only biodegradable but also well tolerated in vivo and hence, biocompatible as revealed by histological studies. The lack of formulation-induced local inflammatory responses of paclitaxel chitosan films suggests a new paradigm for localized chemotherapy based on implantable systems.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and characterization of biodegradable chitosan films for local delivery of paclitaxel

Dhanikula

Panchagnula

2004

AAPS J

103

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“…It has been assayed as biomaterial for wound healing and prosthetic material, since it can be biodegraded by enzyme action (Bernardo et al, 2003). Also it is reported to find applications as an antimicrobial compound, as a drug in the treatment of hyperbilirubinaemia and hypercholesterolaemia and, also, it has been prepared and evaluated for its antitumour activity carrying several antineoplastic agents (Blanco et al, 2000).…”

Section: Chitosanmentioning

confidence: 99%

Polysaccharide-Based Nanoparticles for Controlled Release Formulations

Martı́nez¹,

Fernandez²,

Pérez³

et al. 2012

The Delivery of Nanoparticles

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“…In addition, the release rate of CS can be controlled by further crosslinking the matrix with certain chemical crosslinking agents, such as glutaraldehyde (GD) (11) and sodium hydroxide (12), or by using ionic crosslinking interactions with tripolyphosphate (TPP) (13). The CS beads prepared with TPP were shown to increase the drug loading efficiency and prolong the drug release period.…”

Section: Introductionmentioning

confidence: 99%

Chitosan/Polyethylene Glycol Beads Crosslinked with Tripolyphosphate and Glutaraldehyde for Gastrointestinal Drug Delivery

2010

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Abstract. This study reports on the preparation of chitosan (CS)/polyethylene glycol (PEG) hydrogel beads using sodium diclofenac (DFNa) as a model drug. Following the optimization of the polymer to drug ratio, the chitosan beads were modified by ionic crosslinking with sodium tripolyphosphate (TPP). The CS/PEG/DFNa beads obtained from a (w/w/w) ratio of 1/0.5/0.5 with crosslinking in 10% (w/v) TPP at pH 6.0 for 30 min yielded excellent DFNa encapsulation levels with over 90% loading efficiency. The dissolution profile of DFNa from CS/PEG/DFNa beads demonstrated that this formulation was able to maintain a prolonged drug release for approximately 8 h. Among the formulations tested, the CS/PEG/ DFNa (1/0.5/1 (w/w/w)) beads crosslinked with a combination of TPP (10% (w/v) for 30 min) and glutaraldehyde (GD) (5% (w/v)) were able to provide minimal DFNa release in the gastric and duodenal simulated fluids (pH 1.2 and 6.8, respectively) allowing for a principally gradual drug release over 24 h in the intestinal (jejunum and ileum) simulated fluid (pH 7.4). Thus, overall the CS/PEG beads crosslinked with TPP and GD look to be a promising and novel alternative gastrointestinal drug release system.

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Chitosan microspheres in PLG films as devices for cytarabine release

Cited by 61 publications

References 12 publications

Development and characterization of biodegradable chitosan films for local delivery of paclitaxel

Development and characterization of biodegradable chitosan films for local delivery of paclitaxel

Polysaccharide-Based Nanoparticles for Controlled Release Formulations

Chitosan/Polyethylene Glycol Beads Crosslinked with Tripolyphosphate and Glutaraldehyde for Gastrointestinal Drug Delivery

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