Chitosan-modified PLGA polymeric nanocarriers with better delivery potential for tamoxifen

Thakur, Chanchal Kiran; Thotakura, Nagarani; Kumar, Rajendra; Kumar, Pramod; Singh, Bhupinder; Raza, Kaisar

doi:10.1016/j.ijbiomac.2016.08.080

Cited by 54 publications

(18 citation statements)

References 25 publications

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“…Previous attempts reacted chitosan in solution with a PLGA film to create a positively-charged surface aiming to create nanofibers without the need for purification [24]. Another researcher produced the hybrid PLGA-chitosan polymer for the creation of nanoparticles, but it required harsh conditions (concentrated nitric acid) [26]. Therefore, to create a pure, reproducible, and controllable hybrid polymer that could be used in solution for NP formation, a reaction was performed under milder conditions on a PLGA film created by evaporating PLGA on a surface activating it with EDC and NHS and reacting it with a large excess of chitosan.…”

Section: Resultsmentioning

confidence: 99%

Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications

et al. 2020

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Discovering new materials to aid in the therapeutic delivery of drugs is in high demand. PLGA, a FDA approved polymer, is well known in the literature to form films or nanoparticles that can load, protect, and deliver drug molecules; however, its incompatibility with certain drugs (due to hydrophilicity or charge repulsion interactions) limits its use. Combining PLGA or other polymers such as polycaprolactone with other safe and positively-charged molecules, such as chitosan, has been sought after to make hybrid systems that are more flexible in terms of loading ability, but often the reactions for polymer coupling use harsh conditions, films, unpurified products, or create a single unoptimized product. In this work, we aimed to investigate possible innovative improvements regarding two synthetic procedures. Two methods were attempted and analytically compared using nuclear magnetic resonance (NMR), fourier-transform infrared spectroscopy (FT-IR), and dynamic scanning calorimetry (DSC) to furnish pure, homogenous, and tunable PLGA-chitosan hybrid polymers. These were fully characterized by analytical methods. A series of hybrids was produced that could be used to increase the suitability of PLGA with previously non-compatible drug molecules.

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Section: Resultsmentioning

confidence: 99%

Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications

et al. 2020

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“…[71] The synthesis of the copolymer of PLGA and CS, the PLGA-CS, is usually carried out by the reaction of the activated acid-terminated PLGA with the amine groups of CS. [72] Niu et al proposed another method to produce PLGA-CS copolymers based on a water-in-oil (w/o) emulsion, in which the aqueous phase was composed by CS and HOBt in water, and the organic phase consisted on PLGA, Span 80 and EDC in a chloroform solution. [73] CS is known to be a weak alkaline polysaccharide, which renders it the ability to neutralize the acidity associated with the PLGA degradation process.…”

Section: Amphiphilic Copolymersmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

213

133

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Poly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.

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“…All the characteristics bands of the polymers (CS and PLGA) were present in the spectrum of these magnetopolymeric particles, hence demonstrating that the shell observed in Figure 2 corresponded well to the PLGA and CS shells onto the γ -Fe 2 O 3 nuclei. Chemical groups identified in the spectra were: (A) overlapped stretching vibrations from N–H and O–H bonds (at ≈3400 cm −1 ) [ 109 , 110 , 111 ]; (B) C–H bond stretching vibration of −CH, −CH 2 , and −CH 3 groups (at ≈2850 cm −1 ) [ 109 , 110 , 112 ]; (C) C = O bond stretching vibration of a carboxylic acid (at ≈1750 cm −1 ), probably from the PLGA shell [ 111 , 113 , 114 ]; (D) C = O bond stretching vibration of an amide group, presumably from the CS coating (≈1630 cm −1 ) [ 110 , 112 , 115 ]; (E) asymmetric CH 2 bending vibration (at ≈1450 and ≈1380 cm −1 ) [ 110 , 112 , 113 ], and O–H bending vibration, probably from the carboxylic group in the PLGA shell (at ≈1420 cm −1 ) [ 104 ]; (F) C–O bond stretching vibrations from a −OH group (at ≈1280 cm −1 ) [ 116 ]; (G) C–O bond stretching vibration from the carboxylic group in PLGA (at ≈1160 cm −1 ) [ 104 , 116 ]; (H) C–O–C bond stretching vibration from PLGA (at ≈1130 and ≈1080 cm −1 ) [ 97 , 104 , 112 ]; (I) medium band characteristic of alkanes (at ≈890 cm −1 ) [ 117 ]; (J) CH rocking vibration characteristic of –CH long chains (at ≈800 cm −1 ) [ 104 , 117 ]; and, (K) Fe–O bond vibration from pure iron oxide NPs (at ≈560 cm −1 ) [ 104 , 118 , 119 ].…”

Section: Resultsmentioning

confidence: 99%

A Tri-Stimuli Responsive (Maghemite/PLGA)/Chitosan Nanostructure with Promising Applications in Lung Cancer

2021

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A (core/shell)/shell nanostructure (production performance ≈ 50%, mean diameter ≈ 330 nm) was built using maghemite, PLGA, and chitosan. An extensive characterization proved the complete inclusion of the maghemite nuclei into the PLGA matrix (by nanoprecipitation solvent evaporation) and the disposition of the chitosan shell onto the nanocomposite (by coacervation). Short-term stability and the adequate magnetism of the nanocomposites were demonstrated by size and electrokinetic determinations, and by defining the first magnetization curve and the responsiveness of the colloid to a permanent magnet, respectively. Safety of the nanoparticles was postulated when considering the results from blood compatibility studies, and toxicity assays against human colonic CCD-18 fibroblasts and colon carcinoma T-84 cells. Cisplatin incorporation to the PLGA matrix generated appropriate loading values (≈15%), and a dual pH- and heat (hyperthermia)-responsive drug release behaviour (≈4.7-fold faster release at pH 5.0 and 45 °C compared to pH 7.4 and 37 °C). The half maximal inhibitory concentration of the cisplatin-loaded nanoparticles against human lung adenocarcinoma A-549 cells was ≈1.6-fold less than that of the free chemotherapeutic. Such a biocompatible and tri-stimuli responsive (maghemite/PLGA)/chitosan nanostructure may found a promising use for the effective treatment of lung cancer.

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Chitosan-modified PLGA polymeric nanocarriers with better delivery potential for tamoxifen

Cited by 54 publications

References 25 publications

Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications

Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

A Tri-Stimuli Responsive (Maghemite/PLGA)/Chitosan Nanostructure with Promising Applications in Lung Cancer

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