Chitosan nanocomposite films based on halloysite nanotubes modification for potential biomedical applications

Xie, Mei; Huang, Kaibing; Yang, Fan; Wang, Ruina; Han, Lei; Han, Yu; Ye, Ziru; Wu, Fenxia

doi:10.1016/j.ijbiomac.2019.10.154

Cited by 47 publications

(15 citation statements)

References 62 publications

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“…Therefore, it can be seen that such a range of different interactions can significantly affect the characteristics of the films. Similar anomalous behaviour was previously reported for chitosan-based composite coatings -in fact, literature reports different effects on the EB value in coatings containing organic stabilisers or inorganic powders, and an increase in the concentration of these components did not lead to a linear increase/decrease [29,30]. Indeed, other properties of the films such as PDF, DB and WU/ time (Fig.…”

Section: Optimisation Of the Mechanical Properties: Experimental Designsupporting

confidence: 85%

Films of chitosan and natural modified hydroxyapatite as effective UV-protecting, biocompatible and antibacterial wound dressings

Cunha

Castro

Sousa

et al. 2020

International Journal of Biological Macromolecules

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Chitosan is a natural polysaccharide widely used in biomedicine, for instance for wound dressing. Hydroxyapatite is a very bioactive calcium phosphate which, if modified with an appropriate element (iron Fe), can also have UVabsorbing properties. In this work, we report the study of films of chitosan incorporated with iron-modified hydroxyapatite of natural origin (from cod fish bones); this combination led to an innovative chitosan-based material with excellent and advanced functional properties. The films showed very high UV absorption (Ultraviolet Protection Factor (UPF) value higher than 50). This is the first time that a chitosan-based material has shown such high UV protection properties. The films also showed to be non-cytotoxic, and possessed antimicrobial activity towards both Gram-positive and negative strains. Their mechanical properties, optimised with an experimental design approach, confirmed their potential use as multifunctional wound dressing, capable of reducing bacterial infections and, at the same time, protecting from UV light.

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Section: Optimisation Of the Mechanical Properties: Experimental Designsupporting

confidence: 85%

Films of chitosan and natural modified hydroxyapatite as effective UV-protecting, biocompatible and antibacterial wound dressings

Cunha

Castro

Sousa

et al. 2020

International Journal of Biological Macromolecules

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“…In recent years, hybrid nanomaterials composed by biopolymers and inorganic nanoparticles have attracted growing interest within several fields, including biomedicine [ 1 , 2 , 3 , 4 , 5 ], pharmaceutics [ 6 , 7 , 8 , 9 , 10 ], food packaging [ 11 , 12 , 13 , 14 , 15 ], remediation [ 16 , 17 ] and cultural heritage [ 18 , 19 , 20 ]. As evidenced in a recent review [ 21 ], both ionic and non-ionic polysaccharides can be suitable polymers for the development of functional nanocomposites, with excellent performances in terms of thermal stability, barrier properties and mechanical behavior.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the chitosan/kaolinite nanocomposites exhibited better mechanical performances (in terms of tensile strength) with respect to those of the pristine biopolymer [ 29 ]. Recently, halloysite was largely investigated as a filler of chitosan in different phases, including aqueous suspensions [ 21 , 30 ], hydrogels [ 6 , 17 ] and solid films [ 1 , 31 ]. Composite scaffolds for tissue engineering purposes were obtained by filling chitosan with halloysite through the solution-mixing and freeze-drying methods [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Halloysite Nanotubes Coated by Chitosan for the Controlled Release of Khellin

2020

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In this work, we have developed a novel strategy to prepare hybrid nanostructures with controlled release properties towards khellin by exploiting the electrostatic interactions between chitosan and halloysite nanotubes (HNT). Firstly, khellin was loaded into the HNT lumen by the vacuum-assisted procedure. The drug confinement within the halloysite cavity has been proved by water contact angle experiments on the HNT/khellin tablets. Therefore, the loaded nanotubes were coated with chitosan as a consequence of the attractions between the cationic biopolymer and the halloysite outer surface, which is negatively charged in a wide pH range. The effect of the ionic strength of the aqueous medium on the coating efficiency of the clay nanotubes was investigated. The surface charge properties of HNT/khellin and chitosan/HNT/khellin nanomaterials were determined by ζ potential experiments, while their morphology was explored through Scanning Electron Microscopy (SEM). Water contact angle experiments were conducted to explore the influence of the chitosan coating on the hydrophilic/hydrophobic character of halloysite external surface. Thermogravimetry (TG) experiments were conducted to study the thermal behavior of the composite nanomaterials. The amounts of loaded khellin and coated chitosan in the hybrid nanostructures were estimated by a quantitative analysis of the TG curves. The release kinetics of khellin were studied in aqueous solvents at different pH conditions (acidic, neutral and basic) and the obtained data were analyzed by the Korsmeyer–Peppas model. The release properties were interpreted on the basis of the TG and ζ potential results. In conclusion, this study demonstrates that halloysite nanotubes wrapped by chitosan layers can be effective as drug delivery systems.

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“…Chitosan is a polysaccharide derived from chitin (the second most abundant polymer in nature) and is essentially composed of (β)-1,4 d -glucosamine linked to N -Acetyl- d -glucosamine residues [ 21 , 22 ]. Qo displays unique properties such as biodegradability and biocompatibility proving to be a simple and cost-effective alternative with many applications such as food safety and biomedicine [ 23 , 24 ]. Qo is known to have antibacterial and antibiofilm properties in Gram-positive bacteria such as Staphylococcus aureus and Gram-negative like Escherichia coli and Salmonella typhimurium [ 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antibiofilm Capacity of Chitosan Nanoparticles against Wild Type Strain of Pseudomonas sp. Isolated from Milk of Cows Diagnosed with Bovine Mastitis

et al. 2020

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Bovine mastitis (BM) is the most prevalent bacterial infection in the livestock sector, affecting the dairy industry greatly. The prevention and treatment of this disease is mainly made via antibiotics, but the increasing antimicrobial resistance of pathogens has affected the efficiency of conventional drugs. Pseudomonas sp. is one of the pathogens involved in this infection. The therapeutic rate of cure for this environmental mastitis-causing pathogen is practically zero, regardless of treatment. Biofilm formation has been one of the main virulence mechanisms of Pseudomonas hence presenting resistance to antibiotic therapy. We have manufactured chitosan nanoparticles (NQo) with tripolyphosphate (TPP) using ionotropic gelation. These NQo were confronted against a Pseudomonas sp. strain isolated from milk samples of cows diagnosed with BM, to evaluate their antimicrobial and antibiofilm capacity. The NQo showed great antibacterial effect in the minimum inhibitory concentrations (MIC), minimum bactericidal concentration (MBC) and disk diffusion assays. Using sub lethal concentrations, NQo were tested for inhibition of biofilm formation. The results show that the nanoparticles exhibited biofilm inhibition and were capable of eradicate pre-existing mature biofilm. These findings indicate that the NQo could act as a potential alternative to antibiotic treatment of BM.

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Chitosan nanocomposite films based on halloysite nanotubes modification for potential biomedical applications

Cited by 47 publications

References 62 publications

Films of chitosan and natural modified hydroxyapatite as effective UV-protecting, biocompatible and antibacterial wound dressings

Films of chitosan and natural modified hydroxyapatite as effective UV-protecting, biocompatible and antibacterial wound dressings

Halloysite Nanotubes Coated by Chitosan for the Controlled Release of Khellin

Antimicrobial and Antibiofilm Capacity of Chitosan Nanoparticles against Wild Type Strain of Pseudomonas sp. Isolated from Milk of Cows Diagnosed with Bovine Mastitis

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