Chitosan nanocomposite for tissue engineering and regenerative medicine: A review

Gupta, Priti; Sharma, Shilpa; Jabin, Shagufta; Jadoun, Sapana

doi:10.1016/j.ijbiomac.2023.127660

Cited by 17 publications

(2 citation statements)

References 209 publications

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“…Therefore, determining the appropriate degradation rate is a crucial consideration in hydrogel design. Fortunately, there has been significant recent progress by researchers, including the utilization of surface modification, polymer blending, and incorporation of alkaline particles to enhance biodegradability ( Gupta et al, 2024 ).…”

Section: Overview Of Hydrogelmentioning

confidence: 99%

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Guo,

Dong,

Wang

2024

Front. Bioeng. Biotechnol.

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Periodontal disease is the most common type of oral disease. Periodontal bone defect is the clinical outcome of advanced periodontal disease, which seriously affects the quality of life of patients. Promoting periodontal tissue regeneration and repairing periodontal bone defects is the ultimate treatment goal for periodontal disease, but the means and methods are very limited. Hydrogels are a class of highly hydrophilic polymer networks, and their good biocompatibility has made them a popular research material in the field of oral medicine in recent years. This paper reviews the current mainstream types and characteristics of hydrogels, and summarizes the relevant basic research on hydrogels in promoting periodontal tissue regeneration and bone defect repair in recent years. The possible mechanisms of action and efficacy evaluation are discussed in depth, and the application prospects are also discussed.

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Section: Overview Of Hydrogelmentioning

confidence: 99%

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Guo,

Dong,

Wang

2024

Front. Bioeng. Biotechnol.

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“…Due to their notable biocompatibility, biodegradability, inherent antibacterial properties, and anti-inflammatory capabilities, electrospun CH fibers are promising candidates for applications in tissue engineering and regenerative medicine. Chitosan-based nanocomposites, owing to their versatility, can be engineered into scaffolds of varying forms and dimensions, adeptly mimicking the natural extracellular matrix and thus facilitating cell adhesion, proliferation, and differentiation—critical processes for creating an ideal microenvironment for tissue regeneration [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Potential and Biocompatibility of Chitosan/Polycaprolactone Nanofibrous Membranes Incorporated with Silver Nanoparticles

Korniienko,

Husak,

Diedkova

et al. 2024

Polymers

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This study addresses the need for enhanced antimicrobial properties of electrospun membranes, either through surface modifications or the incorporation of antimicrobial agents, which are crucial for improved clinical outcomes. In this context, chitosan—a biopolymer lauded for its biocompatibility and extracellular matrix-mimicking properties—emerges as an excellent candidate for tissue regeneration. However, fabricating chitosan nanofibers via electrospinning often challenges the preservation of their structural integrity. This research innovatively develops a chitosan/polycaprolactone (CH/PCL) composite nanofibrous membrane by employing a layer-by-layer electrospinning technique, enhanced with silver nanoparticles (AgNPs) synthesized through a wet chemical process. The antibacterial efficacy, adhesive properties, and cytotoxicity of electrospun chitosan membranes were evaluated, while also analyzing their hydrophilicity and nanofibrous structure using SEM. The resulting CH/PCL-AgNPs composite membranes retain a porous framework, achieve balanced hydrophilicity, display commendable biocompatibility, and exert broad-spectrum antibacterial activity against both Gram-negative and Gram-positive bacteria, with their efficacy correlating to the AgNP concentration. Furthermore, our data suggest that the antimicrobial efficiency of these membranes is influenced by the timed release of silver ions during the incubation period. Membranes incorporated starting with AgNPs at a concentration of 50 µg/mL effectively suppressed the growth of both microorganisms during the early stages up to 8 h of incubation. These insights underscore the potential of the developed electrospun composite membranes, with their superior antibacterial qualities, to serve as innovative solutions in the field of tissue engineering.

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Applications of Biodegradable Polymers in the Encapsulation of Anticancer Metal Complexes

Redrado,

Xiao,

Upitak

et al. 2024

Adv Funct Materials

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Metal complexes have recently attracted a lot of attention, particularly as anticancer and antibacterial agents, owing to their versatile mechanisms and easily tunable characteristics. However, the application of such compounds in a medical context, especially in cancer treatment, has been hampered due to their limited solubility and stability in water and aqueous solutions, as well as a lack of selectivity. To address these limitations, several approaches have been developed to improve the targeted delivery of these compounds and their solubility. The first strategy involves the physical encapsulation of these metal complexes within carriers to facilitate controlled drug release. The second strategy involves covalently linking metal complexes to polymers, creating prodrugs that can be converted to active drugs at a more controllable rate. Despite the increasing variety of polymers available, the need to develop those able to be metabolized by the body, producing non‐toxic residues, remains crucial for effective treatment, particularly in the area of diseases such as cancer. In this perspective article, an overview of recent developments in the encapsulation of metal complexes using biodegradable polymers for cancer therapy is provided. It is specifically highlighting how the formed nanoparticles (NPs) enhance the selectivity and toxicity toward cancer cells compared to the parent metal complex, while simultaneously reducing the harmful side effects of traditional chemotherapies, opening the door for using them in combination therapies (PDT, PTT).

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Chitosan nanocomposite for tissue engineering and regenerative medicine: A review

Cited by 17 publications

References 209 publications

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Antibacterial Potential and Biocompatibility of Chitosan/Polycaprolactone Nanofibrous Membranes Incorporated with Silver Nanoparticles

Applications of Biodegradable Polymers in the Encapsulation of Anticancer Metal Complexes

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