Chitosan Nanofiber

Ohkawa, Kousaku; Minato, Ken-ichi; Kumagai, Go; Hayashi, Shinya; Yamamoto, Hiroyuki

doi:10.1021/bm0604395

Cited by 175 publications

(108 citation statements)

References 30 publications

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“…Under optimized conditions, homogenous chitosan fibers with a mean diameter of 330 nm were prepared. Another study conducted by Ohkawa et al [13] focused on optimizing the viscosity of chitosan solutions in order to decrease the average fiber diameter. It was determined that fiber diameter and polymer concentration have an inverse relationship.…”

Section: Electrospinning Of Chitosan 21 Electrospinning Of Pure Chimentioning

confidence: 99%

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Sun¹,

Li²

2011

Express Polym. Lett.

218

101

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Chitosan is soluble in most acids. The protonation of the amino groups on the chitosan backbone inhibits the electrospinnability of pure chitosan. Recently, electrospinning of nanofibers based on chitosan has been widely researched and numerous nanofibers containing chitosan have been prepared by decreasing the number of the free amino groups of chitosan as the nanofibiers have enormous possibilities for better utilization in various areas. This article reviews the preparations and properties of the nanofibers which were electrospun from pure chitosan, blends of chitosan and synthetic polymers, blends of chitosan and protein, chitosan derivatives, as well as blends of chitosan and inorganic nanoparticles, respectively. The applications of the nanofibers containing chitosan such as enzyme immobilization, filtration, wound dressing, tissue engineering, drug delivery and catalysis are also summarized in detail

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Section: Electrospinning Of Chitosan 21 Electrospinning Of Pure Chimentioning

confidence: 99%

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Sun¹,

Li²

2011

Express Polym. Lett.

218

101

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“…Chitosan was successfully electrospun into fibers from dissolution of the polymer in trifluoracetic acid (TFA) [10,11] or a co-solvent system of TFA with dichloromethane (DCM) [12], and it was reported that the last solvent improve fiber spinability. Further, Ohkawa et al [10] refers that the success of the chitosan dissolution in TFA was probably a result of the formation of salts between TFA and amino groups along the chitosan chain leading to a smaller interaction between chitosan molecules, which results in a more stable solution to perform electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Effect of neutralization and cross-linking on the thermal degradation of chitosan electrospun membranes

Correia

Gámiz-González

Botelho

et al. 2014

J Therm Anal Calorim

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Thermal degradation of as electrospun chitosan membranes and samples subsequently treated with ethanol and cross-linked with glutaraldehyde (GA) have been studied by thermogravimetry (TG) coupled with an infrared spectrometer (FTIR). The influence of the electrospinning process and cross-linking in the electrospun chitosan thermal stability was evaluated. Up to three degradation steps were observed in the TG data, corresponding to water dehydration reaction at temperatures below 100 ºC, loss of side groups formed between the amine groups of chitosan and trifluoroacetic acid between 150 -270 ºC and chitosan thermal degradation that starts around 250 ºC and goes up to 400 ºC. The Kissinger model was employed to evaluate the activation energies of the electrospun membranes during isothermal experiments and revealed that thermal degradation activation energy increases for the samples processed by electrospinning and subsequent neutralization and cross-linking treatments with respect to the neat chitosan powder.

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“…Nanofibre is produced by electrospining technique in which fabrication of polymers fibre in a fine and dense meshworks directly from solution and requires a electric field and having dimension less than 100nm 35 . Polymeric nanofibers are effective carriers for drug delivery and offer advantages such as specific surface with small pore size, porosities, reduced toxicity 36 and increased therapeutic level and biocompatibility 37 .…”

Section: Nanofibrementioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:Over the past few decades, the pursuit and exploration of nanotechnology is likely to have a significant impact on the drugdelivery system. This technology can be envisioned as playing a major role in revolutionizing the future of novel drug delivery system. Nanoparticles (NPs) are one of them which have many potential applications in clinical medicine and research. The encapsulation of therapeutic drugs in the form of nanoparticles shows advantageous effect over their corresponding drugs such as increases drug efficacy, specificity, tolerability and therapeutic index. The current review article focuses on the different nanoparticulate drug-delivery systems including nanoerythrosomes, Superparamagnetic nanoparticles, liposomes, Quantum dots, ceramic nanoparticles and dendrimers as well as their applications in different field.

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Chitosan Nanofiber

Cited by 175 publications

References 30 publications

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Effect of neutralization and cross-linking on the thermal degradation of chitosan electrospun membranes

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