Post-harvest diseases of fruit and vegetables have to be controlled because of the high added value of commodities and the great economic loss related to spoilage. Synthetic fungicides are the first choice worldwide to control post-harvest diseases of fruit and vegetables. However, several problems and constraints related to their use have forced scientists to develop alternatives control means to prevent post-harvest diseases. Physical and biological means, resistance inducers, and GRAS (generally recognized as safe) compounds are the most important alternatives used during the last 20 years. Recently, nanomaterial treatments have demonstrated promising results and they are being investigated to reduce the utilization of synthetic fungicides to control post-harvest rot in fruit and vegetables. The collective information in this review article covers a wide range of nanomaterials used to control post-harvest decays related to each selected fruit crop including grape, citrus, banana, apple, mango, peach, and nectarine. Other examples also used are apricot, guava, avocado, papaya, dragon, pear, longan, loquat, jujubes, and pomegranate fruits.