2021
DOI: 10.3390/pharmaceutics13101686
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Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery

Abstract: The unique properties of chitosan make it a useful choice for various nanoparticulate drug delivery applications. Although chitosan is biocompatible and enables cellular uptake, its interactions at cellular and systemic levels need to be studied in more depth. This review focuses on the various physical and chemical properties of chitosan that affect its performance in biological systems. We aim to analyze recent research studying interactions of chitosan nanoparticles (NPs) upon their cellular uptake and thei… Show more

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Cited by 162 publications
(77 citation statements)
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References 177 publications
(185 reference statements)
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“…It is not a big surprise that despite the hype surrounding nanotechnology to date, very few nanoformulations coated with targeting ligands have passed phase III clinical trials. Most NPs, including those made from chitosan, are taken and removed by the RES (liver, lung, spleen, bone marrow, lymph nodes) before reaching the target tissues [ 125 ]. In the preclinical models reviewed above, there is no doubt that both imaging and reduction in the size of atherosclerotic lesions are feasible with these chitosan-based NP platforms.…”
Section: Future Perspectivesmentioning
confidence: 99%
“…It is not a big surprise that despite the hype surrounding nanotechnology to date, very few nanoformulations coated with targeting ligands have passed phase III clinical trials. Most NPs, including those made from chitosan, are taken and removed by the RES (liver, lung, spleen, bone marrow, lymph nodes) before reaching the target tissues [ 125 ]. In the preclinical models reviewed above, there is no doubt that both imaging and reduction in the size of atherosclerotic lesions are feasible with these chitosan-based NP platforms.…”
Section: Future Perspectivesmentioning
confidence: 99%
“…Chitosan can be used to synthesize different types of drug carriers based on the intended use, as it plays a significant role in soft tissue diseases treatment ( Supplementary Table S1 ) ( Wang W. et al, 2020 ). Chitosan nanoparticles can improve drug stability while retaining the biological properties of chitosan, thereby rendering them suitable as carriers of targeted drugs ( Aibani et al, 2021 ). Chitosan nanoparticles are associated with fewer drug-loading and biological distribution limitations compared with lipid-based nanoparticles.…”
Section: Discussionmentioning
confidence: 99%
“…As a product of the deacetylation of chitin, chitosan is a linear polysaccharide, multi‐functional, and eco‐friendly antifouling polymer 9–12 . Chitosan is nontoxic, biocompatible, and biodegradable, which makes it a polymer of choice for many biomedical and pharmaceutical applications since it was first reported in late 1990s 12 .…”
Section: Introductionmentioning
confidence: 99%