Chitosan nanoparticles for enhancing drugs and cosmetic components penetration through the skin

Ta, Quynh; Ting, Jessica; Harwood, Sophie; Browning, Nicola; Simm, Alan; Ross, Kehinde; Olier, Iván; Al‐Kassas, Raida

doi:10.1016/j.ejps.2021.105765

Cited by 75 publications

(37 citation statements)

References 40 publications

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“…This could be attributed to the presence of greater amounts of chitosan/ collagen peptides nanoparticles in the formulations with φ = 0.4. Chitosan and chitosan-based nanoparticles have been reported to promote the skin absorption of drugs in topical formulations owing to their positive charges which allow their adhesion to the skin surface which is naturally negatively charged [28,77,78]. Chitosan is also known to increase the water content in the stratum corneum enhancing the cell membrane fluidity [28].…”

Section: Atr-ftir Skin Analysismentioning

confidence: 99%

“…Chitosan and chitosan-based nanoparticles have been reported to promote the skin absorption of drugs in topical formulations owing to their positive charges which allow their adhesion to the skin surface which is naturally negatively charged [28,77,78]. Chitosan is also known to increase the water content in the stratum corneum enhancing the cell membrane fluidity [28]. Chitosan/collagen peptides nanoparticles have been reported to have a high positive zeta potential (59.7 mV) [33].…”

Section: Atr-ftir Skin Analysismentioning

confidence: 99%

“…Chitosan has been widely used in topical and transdermal formulations as it has been reported to have many skin benefits, such as moisturizing, antiaging, antioxidant, antimicrobial and wound healing properties [26,27]. It also enhances the skin delivery of active agents due to its cationic nature that allows its adhesion to the negatively charged skin surface [28]. Nevertheless, to date, very few studies investigated the use of chitosan-based Pickering emulsions in dermal and cosmetic applications despite the advancements these formulations proved to achieve [29].…”

Section: Introductionmentioning

confidence: 99%

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Pickering emulsions stabilized with chitosan/collagen peptides nanoparticles as green topical delivery vehicles for cannabidiol (CBD)

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Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Section: Atr-ftir Skin Analysismentioning

confidence: 99%

Section: Atr-ftir Skin Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pickering emulsions stabilized with chitosan/collagen peptides nanoparticles as green topical delivery vehicles for cannabidiol (CBD)

Sharkawy

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Rodrigues

et al. 2021

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…The moisture retention activities of Car-CDs were further assessed according to the established method [ 30 , 31 ]. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Fluorescent carbon dots with excellent moisture retention capability for moisturizing lipstick

Dong

Wang

et al. 2021

J Nanobiotechnol

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Long-lasting moisture retention is a huge challenge to humectants, and effective methods or additives for promote these functions are limited, especially nano-additives. Carbon dots (CDs) have attracted increasing research interest due to its ultra-small size, excellent optical properties and low toxicity, etc. However, most of researches have been focused on the photoexcited CDs and its subsequent photophysical and chemical processes, such as photoluminescence, photodynamic, photothermal and photocatalytic behavior. The intrinsic chemo-physical properties of the pristine CDs are not fully explored. Here, we report an excellent moisture retention capability of a new carmine cochineal-derived CDs (Car-CDs) for the first time. The relationship between the structure of Car-CDs and its moisture retention capability is revealed. More interestingly, the effective applications of Car-CDs in moisturizing lipstick are demonstrated. This work expands the research and application of CDs into a broad, new area, potentially in skin care.

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“…Furthermore, CS nanoparticles (NPs) can pass through tight junctions of skin and deliver drugs to the capillary blood vessels and finally to blood circulation. Al-Kasas et al prepared CS NPs by ionic gelation in order to be test their skin penetration, where they found that NPs prepared with gum arabic were able to penetrate porcine ear skin, showing their ability to deliver the drug transdermally [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin Patches

et al. 2021

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In the present study, the preparation of controlled-released leflunomide (LFD)-loaded skin patches was evaluated, utilizing the combination of chitosan (CS) nanoparticles (NPs) incorporated into suitable poly(l-lactic acid) (PLLA) or poly(lactic-co-glycolic acid) (PLGA) polyester matrices. Initially, LFD-loaded CS NPs of ~600 nm and a smooth surface were prepared, while strong inter-molecular interactions between the drug and the CS were unraveled. In the following step, the prepared LFD-loaded CS NPs were incorporated into PLLA or PLGA, and thin-film patches were prepared via spin-coating. Analysis of the prepared films showed that the incorporation of the drug-loaded CS NPs resulted in a significant increase in the drug’s release rate and extent as compared to neat LFD-loaded polyester patches (i.e., prepared without the use of CS NPs). In-depth analysis of the prepared formulations showed that the amorphization of the drug within the matrix and the increased wetting properties of the prepared CS NPs were responsible for the improved thin-film patch characteristics.

show abstract

Chitosan nanoparticles for enhancing drugs and cosmetic components penetration through the skin

Cited by 75 publications

References 40 publications

Pickering emulsions stabilized with chitosan/collagen peptides nanoparticles as green topical delivery vehicles for cannabidiol (CBD)

Pickering emulsions stabilized with chitosan/collagen peptides nanoparticles as green topical delivery vehicles for cannabidiol (CBD)

Fluorescent carbon dots with excellent moisture retention capability for moisturizing lipstick

Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin Patches

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