Chitosan nanoparticles with controlled size and zeta potential

Benamer-Oudih, Samah; Tahtat, Djamel; Khodja, A. Nacer; Mahlous, Mohamed; Hammache, Yasmina; Guittoum, Abd‐Errahim; Gana, S.

doi:10.1002/pen.26261

Cited by 20 publications

(6 citation statements)

References 39 publications

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“…The bands situated at 1062 cm −1 and 1020 cm −1 correspond to the stretching of C-O bonds. All of these bands correlate well with the FTIR spectra of chitosan that were previously published 109 , 110 . The peaks around 3360 cm −1 (N–H),1640 cm −1 (amide I), 1148 cm −1 (C–N), and 1020 cm −1 (C–O) imply that the adsorption of dye was onto the hydroxyl groups of chitosan via covalent bonding 111 .…”

Section: Adsorption Mechanismsupporting

confidence: 85%

A combined experimental and modeling approach to elucidate the adsorption mechanism for sustainable water treatment via In2S3-anchored chitosan

Mishra,

Roy,

Gadore

et al. 2023

Sci Rep

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A novel Chitosan/Indium sulfide (CS/In2S3) nanocomposite was created by co-precipitating Chitosan and InCl3 in solution, resulting in In2S3 agglomeration on the Chitosan matrix with a remarkable pore diameter of 170.384 Å, and characterized it for the physical and chemical properties. Under optimal conditions (pH = 7, time = 60 min, catalyst dosage = 0.24 g L−1, and dye concentration = 100 mg L-1), the synthesized nanocomposite demonstrated remarkable adsorption capabilities for Victoria Blue (VB), attaining a removal efficiency of 90.81%. The Sips adsorption isotherm best matched the adsorption process, which followed pseudo-second-order kinetics. With a rate constant of 6.357 × 10–3 g mg−1 min−1, the highest adsorption capacity (qm) was found to be 683.34 mg g−1. Statistical physics modeling (SPM) of the adsorption process revealed multi-interaction and multi-molecular adsorption of VB on the CS/In2S3 surface. The nanocomposite demonstrated improved stability and recyclability, indicating the possibility for low-cost, reusable wastewater dye removal adsorbents. These results have the potential to have practical applications in environmental remediation.

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Section: Adsorption Mechanismsupporting

confidence: 85%

A combined experimental and modeling approach to elucidate the adsorption mechanism for sustainable water treatment via In2S3-anchored chitosan

Mishra,

Roy,

Gadore

et al. 2023

Sci Rep

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“…The particle size and potential are the two main indexes used to evaluate the stability of an NP [ 35 ]. The changes in particle size and potential of the synthesized SeNPs, GLSO@NEs, and GLSO@SeNPs in some solutions were measured in the present study.…”

Section: Resultsmentioning

confidence: 99%

Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways

et al. 2023

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Oxidative stress damage of pancreatic β-cells is a key link in the pathogenesis of type 2 diabetes mellitus. A long-term increase of free fatty acids induces the increase of reactive oxygen species (ROS) in β-cells, leading to apoptosis and dysfunction of β-cells. Ganoderma lucidum spore oil (GLSO) is a functional food complex with strong antioxidant activity, but its solubility and stability are poor. In the present study, GLSO-functionalized selenium nanoparticles (GLSO@SeNPs) with high stability and uniform particle size were synthesized by a high-pressure homogeneous emulsification method. The aim of this study was to investigate the protective effects of GLSO@SeNPs on INS-1E rat insulinoma β-cells against palmitic-acid (PA)-induced cell death, as well as the underlying mechanisms. Our results showed that GLSO@SeNPs had good stability and biocompatibility, and they significantly inhibited the PA-induced apoptosis of INS-1E pancreatic cells by regulating the activity of related antioxidant enzymes, including thioredoxin reductase (TrxR), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Western blot analysis showed that GLSO@SeNPs reversed the PA-induced changes in MAPK pathway protein expression levels. Thus, the present findings provided a new theoretical basis for utilizing GLSO@SeNPs as a treatment for type 2 diabetes.

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“…An R 2 value closer to one signifies a better model fit with the actual data. The significance of the model is determined by a lower p-value (<0.05), indicating a considerable impact of the predicted model on the response variable or CQAs [37]. Table 3 provides various predicted models along with their sequential p-values and R 2 values.…”

Section: Optimization Of Nps and Study Of The Factor Affecting Critic...mentioning

confidence: 99%

Quality by design (QbD) approach-based development of optimized nanocarrier to achieve quality target product profile (QTPP)-targeted lymphatic delivery

Maurya,

Ramteke,

Jain

2024

Nanotechnology

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Background: Insulin, vital for diabetes management, faces challenges with poor permeability and stability, demanding enhanced effectiveness and safety measures. Various oral peptide delivery systems have emerged, but non-targeted ones, while preventing degradation, lack the ability to facilitate peptide transport. The limitation lies in their non-selectivity. Intestinal macrophage cells in gut-associated lymphoid tissue express carbohydrate-binding receptors (CBRs), ideal for receptor-mediated endocytosis and peptide delivery.Objective: This study aimed to create mannose ligand conjugated nanoparticles (MNPs) using a quality-by-design (QbD) approach to tackle oral administration challenges. The secondary objective was to identify factors influencing product quality. Lymphatic uptake of NPs was the quality target product profile (QTPP), and the study focused on critical formulation attributes (CFAs) like Mannosylated Chitosan concentrations (MCs) and TPP concentrations, as well as critical process parameters (CPP) such as stirring speed.Methods: MNPs, produced via inotropic gelation, were encapsulated in enteric-coated capsules for protection. The impact of CFAs and CPP on particle size and entrapment was observed through Box-Behnken design (BBD), statistically analyzed with ANOVA (p<0.05). Optimal conditions were determined using desirability values. Characterization involved HPLC, zeta-seizer analysis, SEM for morphology, MTT assay for safety, and cell-line studies for M-cell targeting.Results: SEM revealed oval-shaped NPs with an average size of 245.52±3.37 nm, surface potential of 22.12±2.13, and 76.15±1.3% drug entrapment. MTT assay affirmed safety, while confocal imaging indicated selective M-cell uptake.Conclusion: BBD facilitated optimized NP formulation, providing clear insights into variable significance. Cell-line studies confirmed safety and effective cellular uptake of the NPs.

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Chitosan nanoparticles with controlled size and zeta potential

Cited by 20 publications

References 39 publications

A combined experimental and modeling approach to elucidate the adsorption mechanism for sustainable water treatment via In2S3-anchored chitosan

A combined experimental and modeling approach to elucidate the adsorption mechanism for sustainable water treatment via In2S3-anchored chitosan

Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways

Quality by design (QbD) approach-based development of optimized nanocarrier to achieve quality target product profile (QTPP)-targeted lymphatic delivery

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