Chitosan Oligosaccharide-Stabilized Ferrimagnetic Iron Oxide Nanocubes for Magnetically Modulated Cancer Hyperthermia

Abstract

Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity.

Long‐Term Stability and Reproducibility of Magnetic Colloids Are Key Issues for Steady Values of Specific Power Absorption over Time

“…Although notable improvements in colloidal stability have been reported [42] [43] the best results are reported for a particle size window of 3-10 nm, is well below the optimal size for Fe3O4 particles as heating agents. [30] [44] [45] Maximum values of SPA has been reported for Fe3O4 particles to be around 20-30 nm, [9,46] and therefore colloidal stability is difficult to obtain because not only aggregation but also precipitation processes.…”

Multicomponent, peptide-targeted glycol chitosan nanoparticles containing ferrimagnetic iron oxide nanocubes for bladder cancer multimodal imaging

“…Interestingly, 22 nm ferrimagnetic iron oxide nanocubes (NCs) formed closely at superparamagnetic range could be utilized as MRI or effective hyperthermia agents by encapsulating them in polymers that minimize the aggregation of ferrimagnetic iron oxides. [10][11][12] Unlike superparamagnetic nanoparticles, these ferrimagnetic NCs are difficult to maintain in a dispersed state by themselves. However, as we describe in this paper, multiple 22 nm ferrimagnetic NCs can be contained within a larger chitosan-coated nanoparticle that can be maintained in a dispersed state.…”

Chitosan-Coated Fe₃O₄ Magnetic Nanoparticles as Carrier of Cisplatin for Drug Delivery

“…Thus, it is a nontoxic biocompatible amino polysaccharide that has a number of medical applications in drug release in aqueous solutions at pH < 6.5. Specifically, chitosan oligosaccharide has been applied to a variety of magnetic nanoparticles in order to enhance their colloidal stability and circulation (Zhu et al, 2009;Bae et al, 2012).…”