Chitosan/oxidized sodium alginate/Ca2+ hydrogels: Synthesis, characterization and adsorption properties

Zhang, Linyu; Shen, Bihua; Zheng, Chenmin; Huang, Yufan; Liang, Yingqi; Fei, Peng; Chen, Jianfu; Lai, Wenqiang

doi:10.1016/j.foodhyd.2024.110368

Food Hydrocolloids

2024

DOI: 10.1016/j.foodhyd.2024.110368

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Chitosan/oxidized sodium alginate/Ca2+ hydrogels: Synthesis, characterization and adsorption properties

Linyu Zhang,

Bihua Shen,

Chenmin Zheng

et al.

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2024

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Cited by 3 publications

References 40 publications

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Development of oxidized sodium alginate/silica hybrid as efficient adsorbent for anionic and cationic dyes: mechanism and thermodynamic studies

Alenezi,

Gad,

Albassami

et al. 2024

Biomass Conv. Bioref.

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Development of oxidized sodium alginate/silica hybrid as efficient adsorbent for anionic and cationic dyes: mechanism and thermodynamic studies

Alenezi,

Gad,

Albassami

et al. 2024

Biomass Conv. Bioref.

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pH-sensitive chitosan/sodium alginate/calcium chloride hydrogel beads for potential oral delivery of rice bran bioactive peptides

Liu,

Huang

et al. 2024

Food Chemistry

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Polysaccharide-Based Injectable Hydrogel Loaded with Quercetin Promotes Scarless Healing of Burn Wounds by Reducing Inflammation

Xing,

Du,

Dai

et al. 2024

Biomacromolecules

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Moisture loss, infection, and severe inflammatory reactions are the primary factors affecting burn wound healing and leading to scar formation. Herein, we developed a quercetin-loaded polysaccharide-based injectable hydrogel (named PECE). The PECE consists of oxidized sodium alginate (OAlg) coupled with chitosan (CS) via Schiff bases and electrostatic interactions, while Que is incorporated via hydrogen bonding. Benefiting from the hydroxyl and carboxyl groups, PECE features distinguished moisturizing ability. Additionally, the sustained release of Que imparts remarkable antibacterial activity against Escherichia coli and Staphylococcus aureus. Likewise, PECE demonstrates favorable in vitro anti-inflammatory capacity as released Que significantly downregulates pro-inflammatory factors (IL-6 and TNF-α) secreted by RAW 264.7 macrophages. More importantly, in a rat model of deep second-degree burn wounds, PECE effectively inhibits wound infection, reduces inflammation, and promotes angiogenesis and collagen deposition, ultimately minimizing scar formation. Overall, this work presents a promising strategy for scarless healing of burn wounds.

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Chitosan/oxidized sodium alginate/Ca2+ hydrogels: Synthesis, characterization and adsorption properties

Cited by 3 publications

References 40 publications

Development of oxidized sodium alginate/silica hybrid as efficient adsorbent for anionic and cationic dyes: mechanism and thermodynamic studies

Development of oxidized sodium alginate/silica hybrid as efficient adsorbent for anionic and cationic dyes: mechanism and thermodynamic studies

pH-sensitive chitosan/sodium alginate/calcium chloride hydrogel beads for potential oral delivery of rice bran bioactive peptides

Polysaccharide-Based Injectable Hydrogel Loaded with Quercetin Promotes Scarless Healing of Burn Wounds by Reducing Inflammation

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