Chitosan/Polyvinyl Alcohol/ Lauramidopropyl Betaine/2D‐HOF Mixed Film with Abundant Hydrogen Bonds Acts as High Mechanical Strength Artificial Skin

Abstract

The mechanical properties of artificial skins are complicated to maintain under ensuring air permeability and antimicrobial. Thus, a series of hydrophilic antimicrobial polymer networks are prepared by crosslinking chitosan and polyvinyl alcohol with the lauramidopropyl betaine and hydrogen bond organic framework (CS/PVA/LPB/2D-HOF). The mechanical performance of the control groups and the complex are systematically evaluated to attain an artificial strength skin. The CS/PVA/LPB/2D-HOF complex exhibits strong mechanical abilities than other control groups. By analyzing the IR spectra and the morphology, the synergistic effect of hydrogen bonds between molecules and cracks significantly improves the mechanical properties of the complex. Its maximum tensile strength can reach 29 MPa, and its maximum load capacity can reach 3700 g. Notably, the composite membrane also performs an excellent antimicrobial activity. In vivo and in vitro experiments show that the hybrid membrane can promote tissue regeneration and wound healing (95%). These results may open up the opportunity for future composite material investigations in the artificial skin and tissue engineering field.

Recent advances in the medical applications of hemostatic materials

“…These materials are widely used to manufacture artificial skin [45,46], absorbable sutures [47,48], and drug carriers [49][50][51]. Well-studied polysaccharidebased hemostatic materials include chitosan, cellulose, HA, and alginate.…”

“…These are non-irritants, non-immunogenic, non-hemolytic, histocompatible, and naturally degradable. These materials are widely used to manufacture artificial skin 45 , 46 , absorbable sutures 47 , 48 , and drug carriers 49 - 51 . Well-studied polysaccharide-based hemostatic materials include chitosan, cellulose, HA, and alginate.…”

Comparative study on proton conductivity of a polypyridinyl multicarboxylate-based hydrogen-bonded organic framework and related chitosan composite membrane

“…10 Encouragingly, the shortcomings of CS films can be overcome by mixing CS with other organic polymers, adding inorganic fillers to the CS matrix to generate organic–inorganic hybrid compounds, or performing chemical modification. 11–13 It has been proved that the above methods can effectively combine the advantages of other materials with CS and expand the application of CS membranes in the field of proton conduction. 14–20 The resulting CS-based composite membranes with other fillers such as functionalized nanotubes, 15,16 graphene oxide, 17 sulfonated SiO 2 , 18 heteropolyacids, 19,20 and metal–organic frameworks 14,21,22 usually have excellent separation characteristics and physical and chemical stability.…”

“…Now, HOFs have also become a unique and versatile candidate membrane material in this field to inject new vitality into the field. 11…”

Lignin nanoparticles filled chitosan/polyvinyl alcohol polymer blend as a coating material of urea with a slow‐release property

“…12,20 Blending of chitosan with synthetic polymer has attracted much interest and has been the subject of several studies. 21,22 This method is commonly used for providing desirable Csbased polymeric matrices having versatile properties such as good water barrier property and enhanced mechanical properties while maintaining biodegradability. Poly(vinyl alcohol) (PVA) is a biodegradable water-soluble that produces a film with good flexibility along with a good water retention property.…”