Chitosan production by psychrotolerant Rhizopus oryzae in non-sterile open fermentation conditions

Tasar, Ozden Canli; Erdal, Serkan; Taşkın, Mesut

doi:10.1016/j.ijbiomac.2016.05.007

Cited by 36 publications

(21 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chitosan (CS) is a functional biopolymer and linear polysaccharide obtained from chitin (CT) that has attracted significant interest in biomedical, food, textile and chemical industries. Chitin is a naturally abundant mucopolysaccharide found in wide range of natural sources such as crustaceans, insects, annelids, molluscs, coelenterates, and zygomycetes fungi [1] , [2] , [3] . Depending on the source, CT exists in three different polymorphic forms: α-, β- and γ-chitin, which differ in the arrangement of chains within the crystalline region, leading to distinct networks of hydrogen bonds [4] .…”

Section: Introductionmentioning

confidence: 99%

Mechanochemical synthesis of chitosan submicron particles from the gladius of Todarodes pacificus

Anusha¹,

Fleming²,

Arasu

et al. 2016

Journal of Advanced Research

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Mechanochemical synthesis of chitosan submicron particles from the gladius of Todarodes pacificus

Anusha¹,

Fleming²,

Arasu

et al. 2016

Journal of Advanced Research

View full text Add to dashboard Cite

show abstract

“…In this sense, Rhyzopus oryzae, the main Mucoromycota involved in the CCassociated dysbiosis described herein, may also act as a potential chitosan source in the gut of healthy animals, since this species has been employed in many industrial protocols aimed at chitosan production (72,73,74). This information raises the interesting possibility of testing chitosan and some of its derivatives, as food supplements, in adjuvant protocols aimed at treating or preventing cachexia, which may enhance the current pharmaceutical and biomedical applications of this polysaccharide (75).…”

Section: Discussionmentioning

confidence: 99%

Fungal Dysbiosis Correlates With the Development of Tumour-Induced Cachexia in Mice

Jabès

Maria

Barbosa

et al. 2020

Preprint

View full text Add to dashboard Cite

ABSTRACTCachexia (CC) is a devastating metabolic syndrome associated with a series of underlying diseases that greatly affects life quality and expectancy among cancer patients. Studies involving mouse models, in which CC was induced through inoculation with tumor cells, originally suggested the existence of a direct correlation between the development of this syndrome and changes in the relative proportions of several bacterial groups present in the digestive tract. However, these analyses have focus solely on the characterization of bacterial dysbiosis, ignoring the possible existence of changes in the relative populations of fungi, during the development of CC. Thus, the present study sought to expand such analyses, by characterizing changes that occur in the gut fungal population (mycobiota) of mice, during the development of cancer-induced cachexia. Our results confirm that cachectic animals display significant differences in their gut mycobiota, when compared to healthy controls. Moreover, identification of dysbiotic fungi showed remarkable consistency across successive levels of taxonomic hierarchy. Many of these fungi have also been associated with dysbioses observed in a series of gut inflammatory diseases, such as obesity, Colorectal Cancer (CRC), Myalgic Encephalomyelitis (ME) and Inflammatory Bowel Disease (IBD). Nonetheless, the CC-associated dysbiosis seems to be unique, presenting features observed in both obesity (reduced proportion of Mucoromycota) and CRC/ME/IBD (increased proportions of Sordariomycetes, Saccharomycetaceae and Malassezia). One species of Mucoromycota (Rhyzopus oryzae) stands out as a promising probiotic candidate in adjuvant therapies, aimed at treating and/or preventing the development of CC.

show abstract

“…13,23,24 Production using fungal sources Many microorganisms have been investigated as sources of chitin/ chitosan as well as CGC and ChGC (Table 1), namely fungal species belonging to the Basidiomycetes, Ascomycetes, Deuteromycetes and Zygomycetes, including the filamentous fungi Aspergillus niger, Aspergillus fumigatus, Mucor rouxii, Gongronella butleri and Rhizopus oryzae. 9,15,25,[30][31][32] Yeasts are also a source of chitinous polysaccharides, such as Komagataella pastoris, Candida albicans, Saccharomyces cerevisiae and Schizophyllum commune. 4,11,12,33 The content of chitin/chitosan in the cell-walls is specific to species, age and environmental conditions.…”

Section: Fungal Sources Of Chitinous Polymersmentioning

confidence: 99%

“…Beyond the great availability, biodegradability and biocompatibility, their biological properties, namely non‐toxicity, antimicrobial, antitumoral and antioxidant activity, make chitin, chitosan and their complexes very attractive for numerous applications that include, among others, food, cosmetics and pharmaceutical products, biomedicine and environmental uses …”

Section: Introductionmentioning

confidence: 99%

“…Beyond the great availability, biodegradability and biocompatibility, their biological properties, namely non-toxicity, antimicrobial, antitumoral and antioxidant activity, make chitin, chitosan and their complexes very attractive for numerous applications that include, among others, food, cosmetics and pharmaceutical products, biomedicine and environmental uses. 11,14,15 The present review is focused on the most recent and relevant research on chitinous fungal cell-wall polysaccharides. It starts with the chitinous polysaccharide composition, their sources and production process, followed by extraction and characterization methods, functional properties and their main areas of application.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chitinous polymers: extraction from fungal sources, characterization and processing towards value‐added applications

Araújo

Ferreira

Torres

et al. 2020

J of Chemical Tech & Biotech

View full text Add to dashboard Cite

Chitin, chitosan and their complexes with β‐glucan (chitin–glucan complex, CGC, and chitosan–glucan complex, ChGC) are value‐added polysaccharides extracted from the cell‐walls of many fungi. Commercial chitin and its deacetylated form, chitosan, are currently obtained from marine waste material, mostly animal sources (crustaceans and marine invertebrates), through harsh chemical procedures that have low reproducibility due to the variability of the composition of the sources and their seasonal character. These disadvantages are overcome by using fungi as sources of chitinous polymers. The extraction of chitin/chitosan from fungi cell‐walls has the great advantage of yielding products with stable composition and properties, using simpler procedures, with the added benefit of also generating CGC and ChGC, two copolymers that combine the proven properties of chitin/chitosan with those of β‐glucans. Over the last decades, fungal chitinous polymers have been the focus of extensive research that included optimization of the cultivation conditions of a wide range of species and the development of optimized extraction, purification and characterization techniques, as well as the demonstration of the biopolymers' biological properties, which include immunomodulatory, anticancer, antioxidant and antimicrobial activity. Given these properties, several attempts were made to develop applications for them in areas ranging from biomedicine and pharmaceuticals to food and agriculture. Despite their wide range of proven functional properties that include the ability to form different polymeric structures, as well as biological activity, fungal chitinous biopolymers are still underexplored. Nevertheless, these biopolymers hold great potential for development into valuable products or applications that are surely worth further investigation. © 2019 Society of Chemical Industry

show abstract

Chitosan production by psychrotolerant Rhizopus oryzae in non-sterile open fermentation conditions

Cited by 36 publications

References 38 publications

Mechanochemical synthesis of chitosan submicron particles from the gladius of Todarodes pacificus

Mechanochemical synthesis of chitosan submicron particles from the gladius of Todarodes pacificus

Fungal Dysbiosis Correlates With the Development of Tumour-Induced Cachexia in Mice

Chitinous polymers: extraction from fungal sources, characterization and processing towards value‐added applications

Contact Info

Product

Resources

About