Chitosan Schiff bases/AgNPs: synthesis, characterization, antibiofilm and preliminary anti-schistosomal activity studies

Hamed, Alaa; Saad, Gamal R.; Abdelhamid, Ismail A.; Abdel‐Aziz, Marwa M.; Taha, Hoda A.; Dahab, Marwa M. Abou El; Elsabeé, Maher Z.

doi:10.1007/s00289-021-03993-3

Cited by 7 publications

(2 citation statements)

References 87 publications

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“…Furthermore, chitosan is nontoxic and harmless, which means that it has good biocompatibility and can be degraded by related enzymes after entering the human body [9]. Numerous researchers have demonstrated that chitosan derivatives have some antibacterial activity and antioxidant activity [10][11][12][13], including Amira A et al who synthesized chitosan Schiff base derivatives containing different heterocyclic groups and determined their antimicrobial activity [14,15]. Cross-linked chitosan Schiff bases mixed with carboxymethyl chitosan (CMC) and graphene quantum dots (GQDs), might have the potential to be utilized for the treatment of Helicobacter pylori [16].…”

Section: Introductionmentioning

confidence: 99%

Preparation of l-Arginine Schiff Bases Modified Chitosan Derivatives and Their Antimicrobial and Antioxidant Properties

et al. 2022

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We successfully prepared a series of l-arginine Schiff bases acylated chitosan derivatives, aiming to improve the antioxidant activity and antimicrobial activity of chitosan by introducing a furan ring, pyridine ring, and l-arginine structure. The accuracy of the structures of ten compounds was characterized by FT-IR and 1H NMR. In terms of DPPH radical scavenging activity, except for compound CR3PCA, the scavenging rate of other compounds was higher than chitosan, especially CRCF and CRBF had strong scavenging abilities. At the same time, in the superoxide-radical scavenging activity assay, CRCF, CRBF, CR3PCA, CR2C3PCA, and CR2B3PCA were comparable to positive control at 1.60 mg/mL. Simultaneously, CRFF, CRCF, and CRBF had a certain inhibitory effect on Botrytis cinerea. Furthermore, the inhibitory effect of CRFF, CRCF, and CR3PCA on Staphylococcus aureus was very well, close to the positive control at 1.00 mg/mL. CRCF and CR2B3PCA showed better inhibitory effects on Escherichia coli than other compounds. The MTT assay was used to determine the cytotoxicity of the chitosan derivatives, which proved their safety to fibroblast cells. In summary, the study indicated that some of these compounds have the potential for further development and utilization in the preparation of antioxidants and antimicrobial agents.

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Section: Introductionmentioning

confidence: 99%

Preparation of l-Arginine Schiff Bases Modified Chitosan Derivatives and Their Antimicrobial and Antioxidant Properties

et al. 2022

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“…The presence of nano material into chitosan Schiff base was established to enhance its anti-microbial activity, 26 and adsorption efficiency, 27 due to its exceptional properties such as thermal stability, adsorption capacity, chemical stability and increase surface area. 28 Many inorganic nanoparticles were used with chitosan Schiff base, such as silver nanoparticles, 29 copper oxide, 30 and zinc oxide. 31 Among these inorganic nanomaterials zinc oxide (ZnO) has been investigated by researcher due to its highly chemical stability, easy to prepare, enhance antimicrobial activity, cytotoxicity activity, highly adsorption capacity and surface area.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel chitosan Schiff base and its ZnO nanocomposite for removal of synthetic dye, antimicrobial, and cytotoxicity activity

Gaafar

El‐Taweel

Fouda

et al. 2022

Journal of Bioactive and Compatible Polymers

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In this work, a novel chitosan Schiff base 4-(2-Hydroxyaniline)pent-3-en-2-one chitosan (2-HyA-CS) and its ZnO nanocomposite (2-HyA-CS/ZnO) were sensitized and characterized by appropriate methods; FTIR, XRD, Elemental analysis, SEM, TEM and TGA. The result of characterization methods confirms the preparation of 2-HyA-CS and 2-HyA-CS/ZnO. The SEM images reveal that chitosan, 2-HyA-CS, and 2-HyA-CS/ZnO have a varied roughness and porous surfaces. The reason for this difference was attributed to the formation of Schiff base 2-HyA-CS and the presence of ZnO nanoparticles in 2-HyA-CS/ZnO. The patterns of XRD and FTIR confirm the formation of 2-HyA-CS and 2-HyA-CS/ZnO. The degree of substitution (DS) of modified chitosan 2-HyA-CS was calculated using Elemental analysis and FTIR.ATR, it was found to be 74%. The adsorption efficiency of the produced adsorbents was compared with pure chitosan to remove of Remazol Brilliant Blue R (RBBR) from an aqueous medium and antimicrobial activity. The removal percentage of RBBR by chitosan, 2-HyA-CS, and 2-HyA-CS/ZnO are 47.12%, 91.9%, and 96.56%, respectively with the following order: 2-HyA-CS/ZnO > 2-HyA-CS > chitosan. Their antimicrobial activities were studied against two Gram negative bacteria ( E. coli and P. aeruginosa), two Gram positive bacteria ( S. aureus and B. cereus) and ( C. albicans) as a yeast strain, the inhibitory zone measurements revealed that the activity of 2-HyA-CS/ZnO is excellent and higher than 2-HyA-CS and pure chitosan. The cytotoxicity of the prepared compound 2-HyA-CS and 2-HyA-CS/ZnO along with pure chitosan was estimated against two human cancer cells MCF-7 cells and HepG-2 cells, the result indicates that 2-HyA-CS/ZnO having higher Inhibitory activity against both MCF-7 and HepG-2 cells with 53.5 ± 2.86 and 27.4 ± 1.23 µg/mL respectively and 2-HyA-CS possessing moderate Inhibitory activity against both MCF-7 and HepG-2 cancer cells with IC50 = 216.5 ± 7.48 and 135.6 ± 6.49 µg/ml respectively.

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Pyridine and isoxazole substituted 3-formylindole-based chitosan Schiff base polymer: Antimicrobial, antioxidant and in vitro cytotoxicity studies on THP-1 cells

Ali

Aswathy

Munuswamy-Ramanujam

et al. 2023

International Journal of Biological Macromolecules

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Chitosan Schiff bases/AgNPs: synthesis, characterization, antibiofilm and preliminary anti-schistosomal activity studies

Cited by 7 publications

References 87 publications

Preparation of l-Arginine Schiff Bases Modified Chitosan Derivatives and Their Antimicrobial and Antioxidant Properties

Preparation of l-Arginine Schiff Bases Modified Chitosan Derivatives and Their Antimicrobial and Antioxidant Properties

Synthesis of novel chitosan Schiff base and its ZnO nanocomposite for removal of synthetic dye, antimicrobial, and cytotoxicity activity

Pyridine and isoxazole substituted 3-formylindole-based chitosan Schiff base polymer: Antimicrobial, antioxidant and in vitro cytotoxicity studies on THP-1 cells

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