Chitosan–Sodium Lauryl Sulfate Nanoparticles as a Carrier System for the In Vivo Delivery of Oral Insulin

Abstract

The present work explores the possibility of formulating an oral insulin delivery system using nanoparticulate complexes made from the interaction between biodegradable, natural polymer called chitosan and anionic surfactant called sodium lauryl sulfate (SLS). The interaction between chitosan and SLS was confirmed by Fourier transform infrared spectroscopy. The nanoparticles were prepared by simple gelation method under aqueous-based conditions. The nanoparticles were stable in simulated gastric fluids and could protect the encapsulated insulin from the GIT enzymes. Additionally, the in vivo results clearly indicated that the insulin-loaded nanoparticles could effectively reduce the blood glucose level in a diabetic rat model. However, additional formulation modifications are required to improve insulin oral bioavailability.

Co-assembly in chitosan–surfactant mixtures: thermodynamics, structures, interfacial properties and applications

“…In a first instance this causes a rather limited solubility of the mixtures which can be exploited for the preparation of capsules [75,76,80,81,102,104,[214][215][216]. These capsules were shown to be able to efficiently adsorb metal ions such as Cu(II) [76] as well as organic dyes [215,216] but they can also be employed as drug carrier systems [80,214]. For instance, chitosan-SDS complexes were shown to efficiently protect insulin in the gastric tract from digestive enzymes [214].…”

“…These capsules were shown to be able to efficiently adsorb metal ions such as Cu(II) [76] as well as organic dyes [215,216] but they can also be employed as drug carrier systems [80,214]. For instance, chitosan-SDS complexes were shown to efficiently protect insulin in the gastric tract from digestive enzymes [214]. However, further work is necessary to improve the successive availability of insulin.…”

Chitosan nanoparticles: a survey of preparation methods

“…One work reports the use of sodium lauryl sulfate (Elsayed et al 2011). In some cases, both the aforementioned (Calvo et al 1997, Carvalho et al 2009, Fan et al 2012, is also an important task.…”

Oral Delivery of Insulin: Novel Approaches

“…Moreover, human studies were conducted where twenty-five healthy volunteers participated in five studies using a twophase, two-sequence crossover design with a washout period of one day [102]. Other chitosan fatty acid systems were also formulated, for example chitosan sodium lauryl sulphate nanoparticles [103] and chitosan-oleic acid nanoemulsion (particle size reduced by a high pressure homogenizer) and their hypoglycaemic effects were evaluated and compared to the chitosan-oleic acid-surfactants system.…”

“…Other chitosan fatty-acid systems were also developed and compared to the above mentioned system. For example, chitosan-sodium lauryl sulphate nanoparticles dispersed in an aqueous vehicle elicited a pharmacological response after oral administration [103]. However, the pharmacological availability was poor -1.1% versus 29% for nanoparticles dispersed in an oily vehicle.…”