Chitosan-Urushiol nanofiber membrane with enhanced acid resistance and broad-spectrum antibacterial activity

Jie, Xiaoyu; Shiu, Bing‐Chiuan; Zhang, Yuchi; Wu, Huilu; Ye, Yuansong; Fang, Run

doi:10.1016/j.carbpol.2023.120792

Cited by 21 publications

(7 citation statements)

References 66 publications

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“…As an environment-friendly and renewable natural material with good antimicrobial effects, urushiol, mostly extracted from lacquer sap, exhibits a range of biological activities, such as antibacterial, antioxidant, antiviral, and immunological properties ( Kim et al, 2014 ). Urushiol exerts an extensive antibacterial effect on Gram-positive and Gram-negative bacteria ( Jie et al, 2023 ). It has been shown that urushiol additionally provokes cell membrane damage of bacteria and deactivates enzymes involved in fatty acid biosynthesis, limiting the production of toxic bacterial metabolites with its phenolic hydroxyl radicals and unsaturated alkyl chains ( Suk et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of etchant containing an Urushiol monomer from lacquer sap on dentin biostability and bonding performance

Zhao,

Xu,

et al. 2023

Front. Bioeng. Biotechnol.

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Objectives: This study aimed to evaluate the effectiveness of urushiol as an additive to surface acid etchant on dentin structure, by assessing the biostability of dentin, and determine the bonding strengths of dentin and enamel to the composite in the complicated oral microecology.Methods: Etchants with different concentrations of urushiol (0.5, 1, or 3 wt%) were formulated and tested for their bonding performance. Demineralized dentin beams that were etched with experimental etchants were incubated in simulated body fluid solutions by evaluating the weight decrement after 1 month. The effects of urushiol on dentin and matrix metalloproteinases were confirmed by scanning electron microscopy (SEM). Moreover, the antibiotic actions of urushiol on the common cariogenic bacteria Streptococcus mutans, Streptococcus sanguinis, and Streptococcus gordonii as well as the biofilm were evaluated, and its effect on bacterial morphology was observed by scanning electron microscopy. Finally, enamel and dentin specimens were prepared from human molars to determine the depth of demineralization by the etchants and the relationship with the resin bond strengths to enamel and dentin (μTBS) and the morphology of the bonding interface.Results: Urushiol could interact with dentine and inhibit collagenase activity, resulting in biostable dentine. The application of the etchants containing 0.5, 1, or 3 wt% urushiol significantly improved the durability of the dentin bonding interface with its instinctive antibacterial property (p < 0.05).Conclusion: Urushiol not only improves dentin stability by interacting with collagen and inactivating MMP activity but also plays a role in the antibacterial effects in the complicated oral microecology. The effectiveness of urushiol etchant prolongs the longevity of bonded dental restorations without compromising clinical operation time.

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Section: Discussionmentioning

confidence: 99%

Effect of etchant containing an Urushiol monomer from lacquer sap on dentin biostability and bonding performance

Zhao,

Xu,

et al. 2023

Front. Bioeng. Biotechnol.

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“…Currently, most research publications have focused on the fabrication of electrospun nanofibers by directly blending spinning solutions with bioactive compounds from plant extracts, such as chlorogenic acid from coffee [88], essential oil from tea trees [79,107], baicalin from skullcaps [46], and urushiol from lacquer trees [85]. These bioactive compounds contain phenolic compounds, e.g., polyphenols, terpenoids, and flavonoids, that have broad-spectrum antibacterial and antioxidant properties, resulting in increased food preservation [79,197].…”

Section: Food Packagingmentioning

confidence: 99%

Developments of Core/Shell Chitosan-Based Nanofibers by Electrospinning Techniques: A Review

Taokaew,

Chuenkaek

2024

Fibers

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This review is focused on the recent development of various chitosan-based nanofibers (membranes, patches, mats, and scaffolds) that have been designed into core and shell structures using emulsion and coaxial electrospinning techniques. Chitosan, a promising polysaccharide derived from natural sources, holds potential for diverse applications, including nanofiber production, aimed at fostering sustainability. Core/shell chitosan-based nanofibers offer appealing features, including drug encapsulation and sustained release capabilities, with a higher efficiency than uniaxial fibers. The fabrication of core/shell chitosan-based nanofibers, including the co-spinning agents and various spinning parameters, such as spinning voltage, needle size, spinning flow rate, distance from needle tip to collector, temperature, and humidity, is summarized in this work. The review also explores updated applications in various fields, such as textiles, medical dressings, drug release systems, filtration membranes, and food packaging. It highlights the current advancements in core/shell chitosan-based nanofibers produced via electrospinning techniques. The innovative insights presented in the recent literature and the challenges associated with these sustainable materials are thoroughly examined, offering valuable contributions to the field.

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“…Natural polymers suitable for the preparation of nanofibers mainly fall into two categories: polysaccharides and proteins. Polysaccharides include chitosan [ 60 ], starch [ 61 ], alginates [ 62 ], hyaluronic acid [ 63 ], and cellulose [ 64 ]; while protein-based polymers include collagen [ 65 ], gelatin [ 66 ], fibrinogen [ 67 ], silk proteins [ 68 ], sericin [ 69 ], elastin [ 70 ], keratin [ 71 ], and plant proteins [ 72 ]. Table 1 lists the polymers that can be used to prepare nanofibrous scaffolds.…”

Section: Nanofiber Scaffold Technologymentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Jiang

Zheng

et al. 2023

Pharmaceutics

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Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, as well as their spatial structure which mimics the extracellular matrix. However, the use of nanofibers to achieve controlled drug loading and release still presents many challenges, with ongoing research still exploring how to load drugs onto nanofiber scaffolds without loss of activity and how to control their release in a specific spatiotemporal manner. This comprehensive study systematically reviews the applications and recent advances related to drug-laden nanofiber scaffolds for skin-wound management. First, we introduce commonly used methods for nanofiber preparation, including electrostatic spinning, sol–gel, molecular self-assembly, thermally induced phase separation, and 3D-printing techniques. Next, we summarize the polymers used in the preparation of nanofibers and drug delivery methods utilizing nanofiber scaffolds. We then review the application of drug-loaded nanofiber scaffolds for wound healing, considering the different stages of wound healing in which the drug acts. Finally, we briefly describe stimulus-responsive drug delivery schemes for nanofiber scaffolds, as well as other exciting drug delivery systems.

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Chitosan-Urushiol nanofiber membrane with enhanced acid resistance and broad-spectrum antibacterial activity

Cited by 21 publications

References 66 publications

Effect of etchant containing an Urushiol monomer from lacquer sap on dentin biostability and bonding performance

Effect of etchant containing an Urushiol monomer from lacquer sap on dentin biostability and bonding performance

Developments of Core/Shell Chitosan-Based Nanofibers by Electrospinning Techniques: A Review

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

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