Chlamydia and lymphogranuloma venereum in Canada: 2003-2012 Summary report

Totten, S; MacLean, R; Payne, Elizabeth H.; Severini, Alberto

doi:10.14745/ccdr.v41i02a01

Cited by 16 publications

(13 citation statements)

References 12 publications

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“…The study also aims to investigate the specific genotypes associated with the LGV strains in this population in China. LGV outbreaks or increasing prevalence of LGV has appeared during the last decade in many countries in North America, Europe and the Pacific in the form of proctocolitis among MSM 13–16. However, no cases with LGV-related proctocolitis or genotypes associated with LGV have been reported from clinic practice or epidemiological studies2–5 since a case was reported by us in 2007 17.…”

Section: Discussionmentioning

confidence: 95%

Prevalence of anatomically specific infections with Chlamydia trachomatis among men who have sex with men in China: protocol for a nationwide cross-sectional study as part of Disease Burden Surveillance of Infections with Chlamydia (DBSIC)

et al. 2022

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IntroductionChlamydia trachomatis (CT) causes the most prevalent bacterial sexually transmitted infection in the world, and men who have sex with men (MSM) are considered as a high-risk population for this infection. Data regarding the prevalence of CT infection in China are limited and fragmented. In this study, we aim to determine at the national level the anatomically specific CT prevalence and genotype distribution of CT strains among MSM, recruiting from the venues where MSM commonly seek sexual partners.Methods and analysisThe study will be a nationwide cross-sectional survey to estimate the prevalence of chlamydial infections among MSM who meet the inclusion criteria over a period of 6 months (May–October 2022). A total of 2429 participants will be recruited from the venues where MSM most often seek sex partners in 14 cities of the 7 geographical regions in China. A mobile phone app-based anonymous self-administered questionnaire will be used to collect sociodemographic and behavioural data, and specimens of urine, anorectal and pharyngeal swabs will be collected for identifying the infections of CT and Neisseria gonorrhoeae and genotypes of CT. The data will be analysed using the IBM SPSS program V.20Ethics and disseminationThe study protocol has been approved by the Medical Ethics Committee of the Chinese Academy of Medical Sciences Institute of Dermatology and the National Center for STD Control on 9 October 2021 (approval number 2021-KY-037). The study is based on voluntary participation and a written informed consent process. The study results will be submitted for publication in peer-reviewed journals and reported in conferences. The relevant data will be made available to development of control programmes and used as health education materials to disseminate to the community. The dataset will be deposited in a public repository.Trial registration numberChiCTR2100052869.

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Section: Discussionmentioning

confidence: 95%

Prevalence of anatomically specific infections with Chlamydia trachomatis among men who have sex with men in China: protocol for a nationwide cross-sectional study as part of Disease Burden Surveillance of Infections with Chlamydia (DBSIC)

et al. 2022

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“…Using the clinics' EMRs, baseline STI testing rates were determined for the previous year (1 October 2015 to 30 September 2016), and then the number of tests performed on a biweekly basis were tracked prospectively following implementation of the intervention. In addition, testing rates were tracked for the subgroup of women aged 16–29 years, as this population has been shown to be at increased risk for STIs 13 16. Previous STI testing was rare at the participating clinics and the physicians did not generally consider STIs on their differential diagnosis for GU complaints.…”

Section: Measurementmentioning

confidence: 99%

“…Reports of CT incidence across the Niagara Region in Canada are similar to the national average (250/100 000) 13–15. The highest rates are among young women 16. Trichomoniasis is not a reportable infection in Canada, nor with Ontario provincial or Niagara municipal health agencies, thus the local incidence is unknown.…”

Section: Introductionmentioning

confidence: 99%

STI initiative: Improving testing for sexually transmitted infections in women

et al. 2018

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Canadian urgent care and walk-in medical clinics provide health care for a population that may be poorly covered by traditional health care structures. Despite evidence suggesting that women with urinary complaints experience a high incidence of sexually transmitted infections (STIs), this population may be under-tested in this particular setting. The aim of this quality improvement initiative was to increase STI testing in women presenting with GU complaints. Implementation of an opt-out method of STI testing for women ages 16 and older was introduced at three walk-in clinics. Women presenting with GU complaints were given the opportunity to provide samples for both conventional urine culture and nucleic acid amplification testing (NAAT) for non-viral STIs. Patients received treatment according to standard of care and public health was notified as per local regulations. Testing rate and STI incidence was tracked via clinic electronic medical records (EMRs). Overall results were tracked using run charts and compared to historical data for the year prior to the start of the project. Over a 1 year period prior to this intervention, only 65 STI tests were performed in over 1100 GU complaints (5.5%). Six STIs were identified during this time. During the 36-week project period, testing increased to 45% of the patient population (320/707). The STI detected incidence increased from 0.51% to 1.4% in all women, and from 0.84% to 3.4% in women aged 16–29 years. An opt-out method was an effective intervention for increasing STI testing within the walk-in clinic setting. With optimisation, significant increases in testing rates can be obtained without substantially increasing clinic workload and at no economic cost to the clinic. As expected, detected incidence rates of STIs were higher than the recognised population prevalence.

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“…L-genotypes (L1, L2, and L3) are responsible for lymphogranuloma venereum (LGV), whose clinical presentation is associated with inguinal an femoral lymphadenopathies, proctitis, proctocolitis and ulcers, among others ( Ceovic and Jerkovic Gulin, 2015 ; Stoner and Cohen, 2015 ). Traditionally, LGV was an endemic in tropical areas, but LGV is already currently endemic in several European countries and cases have also been reported in Australia and North America ( Hal et al, 2007 ; Totten et al, 2015 ; Donachie et al, 2018 ), mainly associated to men who have sex with men (MSM). In countries with well-established surveillance programs, the incidence is increasing ( Marangoni et al, 2021 ); however, the true extent of the LGV epidemic is not well known.…”

Section: Introductionmentioning

confidence: 99%

Specific high-resolution scheme to improve understanding of the spatio-temporal dispersion of lymphogranuloma venereum epidemic

et al. 2022

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IntroductionLymphogranuloma venereum (LGV) is already endemic in vulnerable populations in several European countries; however, molecular epidemiology data with improved accuracy are necessary to better understand LGV epidemic in these countries. Current strategies to study the molecular epidemiology of LGV cases involve schemes based on a few genetic fragments of Chlamydia trachomatis, which have demonstrated limited discriminatory power for LGV. Therefore, this study aimed to propose a new combination of molecular markers based on the most variable genes of L-genotype genomes to improve the characterization of the current LGV epidemic in Madrid, Spain.MethodsFour genes were selected according to their diversity index (CTLon_0054, CTLon_0087, CTLon_0243 and CTLon_0301) for use in combination with ompA. In silico and experimental studies were performed to compare the previously described multilocus sequence typing (MLST) schemes with our proposal. Moreover, the proposed scheme was applied (n = 68) to analyze the spatio-temporal spread of the LGV cases.ResultsOur proposal demonstrated higher diversity allowing the identification of three main groups compared to the previously published MLST based on hypervariable genes wherein only a single sequence type was identified. The temporal analysis showed that the major cluster was progressively diversifying, revealing a very active transmission chain. Furthermore, an L2b genome identical to that of the origin of the epidemic was detected, suggesting reintroductions or a low screening rate in vulnerable populations. The spatial distribution suggests that the selection and spread of new variants occurs from the central district to the peripheral regions.DiscussionThe scheme proposed in this study has proven to be useful for appropriate discrimination of LGV strains. This study, to our knowledge for the first time, demonstrates a spatio-temporal spread that increases our understanding and identifies areas with special susceptibility for maintenance of the endemic situation of LGV.

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Chlamydia and lymphogranuloma venereum in Canada: 2003-2012 Summary report

Abstract: Background: Chlamydia continues to be the most commonly reported sexually transmitted infection in Canada. Lymphogranuloma venereum (LGV), caused by certain serovars of Chlamydia trachomatis, is becoming established in some populations in a number of Western countries.

Cited by 16 publications

References 12 publications

Prevalence of anatomically specific infections with Chlamydia trachomatis among men who have sex with men in China: protocol for a nationwide cross-sectional study as part of Disease Burden Surveillance of Infections with Chlamydia (DBSIC)

Prevalence of anatomically specific infections with Chlamydia trachomatis among men who have sex with men in China: protocol for a nationwide cross-sectional study as part of Disease Burden Surveillance of Infections with Chlamydia (DBSIC)

STI initiative: Improving testing for sexually transmitted infections in women

Specific high-resolution scheme to improve understanding of the spatio-temporal dispersion of lymphogranuloma venereum epidemic

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