Chlamydia pneumonia infection and risk of multiple sclerosis: A meta-analysis

Arjmandi, Delaram; Graeili, Zahra; Mohammadi, Parisa; Arshadi, Mahdi; Jafari Tadi, Mehrdad; Ardekani, Ali; Naeimi, Reza; Abbasi, Farzaneh; Marhoommirzabak, Elika; Mahjour, Sanaz; Sartip, Behnam; Prasa, Hamid; Fallah Omrani, Vahid; Rostami, Ali

doi:10.1016/j.msard.2023.104862

Multiple Sclerosis and Related Disorders

2023

DOI: 10.1016/j.msard.2023.104862

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Chlamydia pneumonia infection and risk of multiple sclerosis: A meta-analysis

Delaram Arjmandi,

Zahra Graeili,

Parisa Mohammadi

et al.

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2024

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Cited by 3 publications

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How to and should we target EBV in MS?

Eckert,

Jakimovski,

Zivadinov

et al. 2024

Expert Review of Clinical Immunology

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How to and should we target EBV in MS?

Eckert,

Jakimovski,

Zivadinov

et al. 2024

Expert Review of Clinical Immunology

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Gut microbiota in multiple sclerosis and animal models

Schumacher,

Doyle,

Hill

et al. 2024

The FEBS Journal

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Multiple sclerosis (MS) is a chronic central nervous system (CNS) neurodegenerative and neuroinflammatory disease marked by a host immune reaction that targets and destroys the neuronal myelin sheath. MS and correlating animal disease models show comorbidities, including intestinal barrier disruption and alterations of the commensal microbiome. It is accepted that diet plays a crucial role in shaping the microbiota composition and overall gastrointestinal (GI) tract health, suggesting an interplay between nutrition and neuroinflammation via the gut‐brain axis. Unfortunately, poor host health and diet lead to microbiota modifications that could lead to significant responses in the host, including inflammation and neurobehavioral changes. Beneficial microbial metabolites are essential for host homeostasis and inflammation control. This review will highlight the importance of the gut microbiota in the context of host inflammatory responses in MS and MS animal models. Additionally, microbial community restoration and how it affects MS and GI barrier integrity will be discussed.

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Atherosclerosis associated with Chlamydia pneumoniae: Dissecting the etiology

Ozkan,

Kayikcioglu

2024

European Atherosclerosis Journal

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Chlamydia pneumoniae related infections and atherosclerosis are both common entities. Today, the literature presents an enormous amount of data regarding the role of C. pneumoniae in the development and sustainment of atherosclerosis and allowing us to comprehend the molecular mechanisms behind better. The implications of C. pneumoniae in atherogenesis include altered platelet function, hypercoagulability, macrophage dysfunction, vascular smooth muscle proliferation, and increased neutrophilic migration. Therefore, it would not be wrong to implicate that, C. pneumoniae plays important roles in almost every stage of atherogenesis. Furthermore, various serological markers suggestive of active or past C. pneumoniae infection are known to be associated with multiple clinical presentations, such as abdominal aortic aneurysms, subclinical atherosclerosis in the young individuals, aggravated atherosclerosis in heterozygous familial hypercholesterolemia. This review, as a result, aims to provide detailed insights into the pathophysiological mechanisms of atherogenesis associated with C. pneumoniae and its clinical implications.

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Chlamydia pneumonia infection and risk of multiple sclerosis: A meta-analysis

Cited by 3 publications

References 72 publications

How to and should we target EBV in MS?

How to and should we target EBV in MS?

Gut microbiota in multiple sclerosis and animal models

Atherosclerosis associated with Chlamydia pneumoniae: Dissecting the etiology

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