Chlamydia pneumoniae and cytomegalovirus seropositivity, inflammatory markers, and the risk of myocardial infarction at a young age

Gattone, Marinella; Iacoviello, Licia; Colombo, Marilena; Castelnuovo, Augusto Di; Soffiantino, F; Gramoni, Anna; Picco, Daniele; Benedetta, Maria; Giannuzzi, Pantaleo

doi:10.1067/mhj.2001.118118

Cited by 70 publications

(50 citation statements)

References 33 publications

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“…Chronic infection has also been postulated to play a more relevant role in causation of coronary artery disease of an early onset, given that traditional risk factors often do not account entirely for the risk in younger individuals. 22,23 Since our data also show a similar pattern, we suggest that further studies to investigate this association among women should focus on early-onset lung cancer.…”

Section: Dear Sirsupporting

confidence: 74%

Lack of association between chronic Chlamydophila pneumoniae infection and lung cancer among nonsmoking Chinese women in Singapore

Koh

Chow

Phoon

et al. 2004

Intl Journal of Cancer

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Section: Dear Sirsupporting

confidence: 74%

Lack of association between chronic Chlamydophila pneumoniae infection and lung cancer among nonsmoking Chinese women in Singapore

Koh

Chow

Phoon

et al. 2004

Intl Journal of Cancer

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“…37 demonstrated that patients with higher titers of Cpn are at a greater risk for ACS than those with lower titers of Cpn. 38) These findings allowed us to hypothesize that more intense infection of a vulnerable plaque with Cpn and CMV may contribute to plaque rupture causing ACS.…”

Section: Discussionmentioning

confidence: 99%

Presence and Severity of Chlamydia pneumoniae and Cytomegalovirus Infection in Coronary Plaques Are Associated With Acute Coronary Syndromes

et al. 2006

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SUMMARYAlthough an association between Chlamydia pneumoniae (Cpn) or Cytomegalovirus (CMV) infection and coronary atherosclerosis has been reported, such an association is less clear for acute coronary syndromes (ACS). The purpose of this study was to investigate the pathogenic roles of Cpn and CMV infection of coronary plaques in ACS. We divided 38 coronary plaque specimens obtained from 38 patients who underwent directional coronary atherectomy or thrombectomy into an ACS group (n = 21) and a non-ACS group (n = 17). Cpn and CMV in specimens were stained using immunohistochemical techniques and analyzed quantitatively. The detection rate for either Cpn-or CMV-positive cells in ACS patients was slightly higher compared with non-ACS patients. Detection rates for both Cpn-and CMV-positive cells were significantly higher in ACS patients than in non-ACS patients (P = 0.010). Furthermore, the density of Cpn-and CMV-positive cells in plaques was significantly higher in ACS patients than in non-ACS patients (P < 0.003). The results indicate that the presence and severity of Cpn and CMV infection in coronary plaques are greater in patients with ACS compared with non-ACS patients. We conclude that infection with Cpn and CMV in coronary plaques may be involved in the pathogenesis of ACS. (Int Heart J 2006; 47: 511-519)

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“…Doubly seropositive patients also had increased levels of inflammatory markers, including CRP. 15 The issue is not without controversy: in another study showing an association of CRP with CHD, there were no strong associations of four inflammatory markers, including CRP, with Helicobacter pylori or C pneumoniae seropositivity. 16 In a study of mice infected with influenza A, HDL lost its antiinflammatory properties during the acute-phase response.…”

Section: Inflammatory Mechanismsmentioning

confidence: 99%

Inflammation in Atherosclerosis and Implications for Therapy

2004

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Abstract-Atherosclerosis is now understood to be a disease characterized by inflammation that results in a host of complications, including ischemia, acute coronary syndromes (unstable angina pectoris and myocardial infarction), and stroke. Inflammation may be caused by a response to oxidized low-density lipoproteins, chronic infection, or other factors; and markers of this process, such as C-reactive protein, may be useful to predict an increased risk of coronary heart disease. Thus, we believe that inflammatory processes may be potential targets of therapy in preventing or treating atherosclerosis and its complications.

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Chlamydia pneumoniae and cytomegalovirus seropositivity, inflammatory markers, and the risk of myocardial infarction at a young age

Cited by 70 publications

References 33 publications

Lack of association between chronic Chlamydophila pneumoniae infection and lung cancer among nonsmoking Chinese women in Singapore

Lack of association between chronic Chlamydophila pneumoniae infection and lung cancer among nonsmoking Chinese women in Singapore

Presence and Severity of Chlamydia pneumoniae and Cytomegalovirus Infection in Coronary Plaques Are Associated With Acute Coronary Syndromes

Inflammation in Atherosclerosis and Implications for Therapy

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