Chlamydia pneumoniae, and mycoplasma pneumoniae: Are they related to severe asthma in childhood?

Iramain, Ricardo; Jesús, Raùl De; Spitters, Cristopher; Jara, Alfredo; Jiménez, J. Sánchez; Bogado, Norma; Cardozo, Laura

doi:10.3109/02770903.2015.1116085

Cited by 22 publications

(15 citation statements)

References 26 publications

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“…18 I n a p r o s p e c t i v e , c a s e -c o n t r o l s t u d y performed on 82 patients, Iramain et al showed a positive relationship between MP infection and exacerbation severity, and concluded that MP infection played an important role in the development of severe acute asthma. 19 Likewise, in the prospective assessment of 58 patients with acute exacerbation, they found that specific IgM levels were much higher in patients with severe exacerbations both for MP and Chlamydophila pneumoniae. 20 Studies associating the presence of MP in acute exacerbations with the risk of hospitalization were also contradictory.…”

Section: Discussionmentioning

confidence: 97%

Prevalence of Mycoplasma pneumoniae infection in pediatric patients with acute asthma exacerbation

Kassisse¹,

García²,

Prada³

et al. 2018

Arch Argent Pediatr

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Our data suggest that children with acute asthma show a high prevalence (46%) of Mycoplasma pneumoniae infection and that there is a close relation between severe acute asthma exacerbation and the presence of Mycoplasma pneumoniae infection. These findings might result in therapeutic implications centered in the use of specific antibiotics to fight this atypical organism. Key words: acute asthma, exacerbation, Mycoplasma pneumoniae.

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Section: Discussionmentioning

confidence: 97%

Prevalence of Mycoplasma pneumoniae infection in pediatric patients with acute asthma exacerbation

Kassisse¹,

García²,

Prada³

et al. 2018

Arch Argent Pediatr

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“…In humans, infection with M. pneumoniae can favour the development of asthma in predisposed patients and specific treatment with clarithromycin improves pulmonary function (Martin et al, 2001;Kraft et al, 2002;Hansbro et al, 2004;El Sayed Zaki et al, 2009;Atkinson, 2013;Ye et al, 2014). The proportion of asthmatics who have both IgM and IgG for M. pneumoniae increases with clinical severity (Iramain et al, 2016;Yin et al, 2017). In a mouse model, single exposure to a specific toxin of M. pneumoniae was shown to be sufficient to cause asthma-like disease with histological evidence of pulmonary eosinophilic inflammation (Medina et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Detection of specific bacterial agents by quantitative PCR assays in the bronchoalveolar lavage fluid of dogs with eosinophilic bronchopneumopathy vs. dogs with chronic bronchitis and healthy dogs

Canonne

Peters

Roels

et al. 2018

The Veterinary Journal

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In humans, Mycoplasma pneumoniae and Bordetella pertussis infections are suggested to trigger or exacerbate asthma. Whether Mycoplasma or Bordetella are associated with chronic inflammatory bronchial diseases in dogs has not been investigated. The aim of this study was to assess detection rates of Mycoplasma canis (M. canis), M. cynos and Bordetella bronchiseptica (Bb), in dogs with eosinophilic bronchopneumopathy (EBP) and chronic bronchitis (CB), compared with healthy dogs. Specific quantitative PCR (qPCR) analysis for M. canis, M. cynos and Bb were retrospectively performed on bronchoalveolar lavage fluid (BALF) collected from 24 dogs with EBP, 21 dogs with CB and 15 healthy dogs. Possible associations between qPCR results and age, BALF cytology or clinical severity scores (CSS) in dogs with EBP were investigated. There was no difference in M. canis, M. cynos and Bb detection rates in dogs with EBP (n=6, n=2 and n=6, respectively) and dogs with CB (n=2, n=2 and n=2, respectively) compared with control dogs (n=4, n=2 and n=2, respectively). In dogs with EBP, the proportion that were qPCR-positive for Bb was higher in dogs with higher CSS (P=0.014) and BALF from Bb-positive dogs had higher percentage of neutrophils (P<0.001). Among dogs that were qPCR-positive for Bb, moderate to high loads were only detected in dogs with EBP. M. canis and M. cynos detection was not associated with EBP or CB; higher Bb loads were only present in dogs with EBP and high CSS. A possible cause and effect relationship between Bb infection or load and EBP remains unclear and requires further investigation.

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“…18 En un estudio prospectivo caso-control sobre 82 pacientes, Iramain y col. demostraron la asociación positiva entre la infección por MP y la gravedad de la exacerbación, y concluyeron que la infección por MP tenía un papel importante en el desarrollo del asma aguda grave. 19 D e l a m i s m a f o r m a , e n l a e v a l u a c i ó n prospectiva de 58 pacientes con exacerbación aguda, encontraron, de forma significativa, que los niveles de IgM específica fueron mucho más elevados en los pacientes con exacerbaciones graves tanto para MP como para Chlamydophila pneumoniae. 20 Los estudios que han relacionado la presencia de MP en las exacerbaciones agudas con el riesgo de hospitalización también son contradictorios.…”

Section: Discussionunclassified

Prevalencia de la infección por Mycoplasma pneumoniae en pacientes pediátricos con exacerbación aguda del asma

2018

Arch Argent Pediatr

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Prevalencia de la infección por RESUMEN Introducción.El Mycoplasma pneumoniae puede estar implicado en la exacerbación refractaria del asma, Objetivo. Establecer la prevalencia de la infección por Mycoplasma pneumoniae en pacientes con exacerbación aguda del asma. Material y método. Se realizó un estudio prospectivo, transversal, observacional, casocontrol, en pacientes mayores de 2 años y menores de 12. Se determinaron anticuerpos inmunoglobulina M (IgM) para M. pneumoniae por serología por técnica de ensayo por inmunoabsorción ligado a enzima (enzymelinked immunosorbent assay; ELISA en sus siglas en inglés), utilizando el kit NovaLisa ® NovaTec. Se consideró prueba positiva a valores ≥ 11 NTU (NovaTec unidades). El análisis estadístico fue análisis de la varianza (analysis of variance; ANOVA, por sus siglas en inglés) y chi cuadrado con un nivel de significancia de p < 0,05. Resultados. Se estudiaron 180 niños, 130 correspondieron al grupo de niños asmáticos y 50, al grupo control. La IgM específica fue positiva en 60 pacientes, que correspondió al 46,15% de niños asmáticos (p < 0,001). La gravedad de la exacerbación estuvo relacionada directamente con los niveles de IgM (p < 0,001). La tasa de hospitalización fue de 75%, asociada de forma significativa con los niveles de IgM específica (p < 0,001). Conclusión. Nuestros datos sugieren que en los niños con asma aguda, tienen alta prevalencia (46%) de infección por Mycoplasma pneumoniae y estrecha relación entre la exacerbación aguda grave del asma y la infección por Mycoplasma pneumoniae. Estos resultados podrían tener implicaciones terapéuticas orientadas hacia la utilización de antibióticos específicos contra este microorganismo atípico. Palabras clave: asma aguda, exacerbación, Mycoplasma pneumoniae.

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Chlamydia pneumoniae, and mycoplasma pneumoniae: Are they related to severe asthma in childhood?

Abstract: M. pneumoniae and C. pneumoniae may play a role in the development of severe asthma.

Cited by 22 publications

References 26 publications

Prevalence of Mycoplasma pneumoniae infection in pediatric patients with acute asthma exacerbation

Prevalence of Mycoplasma pneumoniae infection in pediatric patients with acute asthma exacerbation

Detection of specific bacterial agents by quantitative PCR assays in the bronchoalveolar lavage fluid of dogs with eosinophilic bronchopneumopathy vs. dogs with chronic bronchitis and healthy dogs

Prevalencia de la infección por Mycoplasma pneumoniae en pacientes pediátricos con exacerbación aguda del asma

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