Chlamydia pneumoniae antibody levels before coronary events in the Helsinki Heart Study as measured by different methods

Paldanius, Mika; Leinonen, Maija; Virkkunen, Hanna; Tenkanen, Leena; Sävykoski, Tiina; Mänttäri, Matti; Saikku, Pekka

doi:10.1016/j.diagmicrobio.2006.04.007

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…Once infected, persons of lower socioeconomic position and those with higher levels of chronic stress may be more likely to experience chronic reactivation of persistent pathogen burden. Some studies have shown that higher IgG antibody response is related to poorer cardiovascular outcomes, suggesting that antibody response may be an important mediator of socioeconomic or psychosocial differences in cardiovascular risk (Adam et al, 1987; Nieto et al, 1996; Paldanius et al, 2006). The combination of earlier pathogen exposure, increased susceptibility to a wider array of pathogens and greater likelihood of stress-related reactivation may be important factors contributing to socioeconomic disparities in cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic and psychosocial gradients in cardiovascular pathogen burden and immune response: The multi-ethnic study of atherosclerosis

Aiello

Diez‐Roux

Noone

et al. 2009

Brain, Behavior, and Immunity

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Section: Discussionmentioning

confidence: 99%

Socioeconomic and psychosocial gradients in cardiovascular pathogen burden and immune response: The multi-ethnic study of atherosclerosis

Aiello

Diez‐Roux

Noone

et al. 2009

Brain, Behavior, and Immunity

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“…Our data agree with former studies, showing a significant association between CP seropositivity and incidence of CVD, which was also relevant after adjustment for the so-called traditional risk factors, such as diabetes, hypertension, hypercholestolemia, etc., as summarized in the GCR score. The reasons for this discrepancy among the reported studies could be due, first of all, to the different methods and definitions of CP infection (seropositivity or DNA detection) and second, to individual differences of the evaluated patients (Paldanius et al 2006). For instance, regarding HD patients, it is well known that different dialytic modalities and membranes may affect immune response and inflammation.…”

Section: Discussionmentioning

confidence: 85%

Impact of seropositivity to Chlamydia pneumoniae and anti-hHSP60 on cardiovascular events in hemodialysis patients

Esposito

Tinelli

Libetta

et al. 2011

Cell Stress and Chaperones

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Autoimmunity to heat shock protein 60 (HSP60) has been related to atherosclerosis. Chlamydia pneumoniae (CP), the most studied infectious agent implicated in promoting atherosclerosis, produces a form of HSP60, which can induce an autoimmune response, due to high antigenic homology with human HSP60 (hHSP60). In this study, we evaluated the correlations among anti-hHSP60 antibodies, CP infection, and cardiovascular disease (CVD) in a high-risk population, such as patients undergoing hemodialysis (HD). Thirty-two patients (67.9±13.9 years; male/female, 23:9) on regular HD were enrolled. Global absolute cardiovascular risk (GCR) was assessed using the Italian CUORE Project's risk charts, which evaluate age, gender, smoking habits, diabetes, systolic blood pressure, and serum cholesterol. The occurrence of cardiovascular events during a 24-month follow-up was recorded. Seropositivity to CP and the presence of anti-hHSP60 antibodies were tested by specific enzyme-linked immunosorbent assays. Inflammation was assessed by measurement of Creactive protein (CRP) serum levels. Fifteen healthy sex and age-matched (61.9± 9.5 years; male/female, 11:4) subjects were the control group. Fifteen of 32 patients resulted seropositive for CP. CP+patients were older than CP−, while they did not differ for GCR, CRP, and dialytic parameters. CVD incidence was significantly higher in CP+ (9 CP+ vs 2 CP−, p<0.05). Cox analysis recognized that the incidence of CVD was independently correlated with seropositivity to CP (HR, 7.59; p=0.01;). On the other hand, there were no significant differences in anti-hHSP60 levels among CP+, CP− and healthy subjects: 18.11 μg/mL (14.8-47.8), 31.4 μg/mL (23.2-75.3), and 24.72 μg/mL (17.7-41.1), respectively. Anti-hHSP60 did not correlate to GCR, CRP, and incidence of CVD. In conclusion, our data suggest that anti-hHSP60 autoimmune response is not related to CP infection and CPrelated CVD risk in HD patients.

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Chlamydia pneumoniae IgG and IgA antibody titers and prognosis in patients with coronary heart disease: results from the CLARICOR trial

Hilden

Lind

Kolmos

et al. 2010

Diagnostic Microbiology and Infectious Disease

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Chlamydia pneumoniae antibody levels before coronary events in the Helsinki Heart Study as measured by different methods

Cited by 5 publications

References 32 publications

Socioeconomic and psychosocial gradients in cardiovascular pathogen burden and immune response: The multi-ethnic study of atherosclerosis

Socioeconomic and psychosocial gradients in cardiovascular pathogen burden and immune response: The multi-ethnic study of atherosclerosis

Impact of seropositivity to Chlamydia pneumoniae and anti-hHSP60 on cardiovascular events in hemodialysis patients

Chlamydia pneumoniae IgG and IgA antibody titers and prognosis in patients with coronary heart disease: results from the CLARICOR trial

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