Chlamydia pneumoniae IgG seropositivity and risk of deep-vein thrombosis

Koster, Ted; Rosendaal, Frits R.; Lieuw-A-Len, D. D.; Kroes, Aloys C.M.; Emmerich, J; Dissel, Jaap T. van

doi:10.1016/s0140-6736(00)02244-3

Cited by 19 publications

(11 citation statements)

References 8 publications

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“…The association between C. peumoniae infection and deep vein thrombosis, was not confirmed in the Leiden Thrombophilia study (6). But, in this study controls were mainly partners of cases and lived in the same environment.…”

Section: Discussioncontrasting

confidence: 64%

Infection and venous thrombosis

Emmerich¹

2002

Pathophysiol Haemos Thromb

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Section: Discussioncontrasting

confidence: 64%

Infection and venous thrombosis

Emmerich¹

2002

Pathophysiol Haemos Thromb

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“…15 Interestingly, C pneumoniae IgG antibody titres of 256 or greater have been associated with deep vein thrombosis, 16 although the association has been questioned. 17 Nevertheless, the idea that C pneumoniae in veins might produce lesions, which sometimes aid thrombosis, is sufficiently plausible to deserve further consideration. We assume that the source of C pneumoniae in the lesions (whether of arteries or veins) is C pneumoniae positive peripheral blood monocytes, 18 which must have easy access to the lesions.…”

Section: Discussionmentioning

confidence: 99%

Chlamydia pneumoniae in infrequently examined blood vessels

Taylor‐Robinson¹,

Thomas²,

Goldin³

et al. 2002

Journal of Clinical Pathology

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Aim: To determine the prevalence of Chlamydia pneumoniae DNA in infrequently examined blood vessels. Methods: Vessels obtained from 15 men and six women at coronary artery bypass surgery were tested by a nested polymerase chain reaction (PCR) assay for C pneumoniae DNA. Results: Chlamydia pneumoniae DNA was detected in four of six atheromatous ascending aorta specimens but in none of eight non-atheromatous aorta specimens, in six of 11 atheromatous internal mammary artery specimens but in none of seven non-atheromatous internal mammary artery specimens, in five of seven long saphenous vein specimens showing evidence of disease but in none of 12 specimens without evidence of disease, and in two of three previously grafted veins. Overall, C pneumoniae occurred significantly more often in diseased than in normal vessels (p = < 0.00001). Conclusions: Chlamydia pneumoniae is often present in diseased areas of arteries, including the internal mammary arteries, and even in diseased areas of veins. It is not present in apparently healthy areas of either type of vessel.C hlamydia pneumoniae, an obligately intracellular microorganism, commonly causes a spectrum of upper and lower respiratory tract diseases in humans.1 It was first associated with coronary heart disease on the basis of a serological study in Finland.2 Although this and further serological data that have accrued in the past 12 years have elicited general interest and dispute, 3-5 the finding of C pneumoniae in the atheromatous lesions of coronary arteries eight years ago 6 intensified interest in the association. Since then, the organisms have been detected by various techniques in the atheromatous lesions of various major arteries that have been examined in more than 30 studies, 7 and of the various microorganisms that could be involved in the pathogenesis of atherosclerosis, evidence for the role of C pneumoniae is relatively strong. 8 "Chlamydia pneumoniae was first associated with coronary heart disease on the basis of a serological study in Finland"We have examined normal and abnormal portions of ascending aortas, internal mammary arteries, and long saphenous veins for the following reasons. First, overall, these vessels have been examined least frequently for C pneumoniae, 7 although they may be obtained readily at coronary artery bypass surgery. Second, internal mammary arteries contain atheromatous lesions less often than many other arteries, so that obtaining normal tissue from them should be easy. Third, veins that are to be used in bypass surgery are not subject to atheromatous changes and yet some have been recorded as C pneumoniae positive. METHODSVessels were obtained from 21 patients (15 men and six women) at coronary artery bypass surgery. Their ages ranged from 52 to 81 years (mean, 65). Specimens of ascending aorta, internal mammary artery (right or left), and long saphenous vein from the upper leg were obtained from each of 14 patients. A sample of internal mammary artery and long saphenous vein, but not aorta, was taken from a further f...

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“…The association is strongest within the first 2 weeks after the onset of infection with a gradual decline thereafter [4,5]. According to one hypothesis, the increased concentration of clotting factor VIII following Chlamydia pneumoniae infection may lead to venous thrombosis [8,9].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of pulmonary embolism with concomitant pneumonia

Cha

Choi²,

Shin³

et al. 2016

Blood Coagulation &Amp; Fibrinolysis

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Although pneumonia is associated with an increased risk of venous thromboembolism, patients with pulmonary embolism and concomitant pneumonia are uncommon. The aim of the present study was to investigate the clinical features of pulmonary embolism with coexisting pneumonia. We retrospectively compared clinical, radiologic and laboratory parameters between patients with pulmonary embolism and concomitant pneumonia (pneumonia group) and those with unprovoked pulmonary embolism (unprovoked group), and then between the pneumonia group and those with pulmonary infarction (infarction group). Of 794 patients with pulmonary embolism, 36 (5%) had coexisting pneumonia and six (1%) had no provoking factor other than pneumonia. Stroke was significantly more common in the pneumonia group, than either the unprovoked group or the infarction group. In the pneumonia group, fever was significantly more common and serum C-reactive protein levels were significantly higher. By contrast, central pulmonary embolism and right ventricular dilation on computed tomography were significantly less frequent in the pneumonia group. In addition, an adverse outcome due to pulmonary embolism was less common in the pneumonia group than in either of the other two groups. The coexistence of pulmonary embolism and pneumonia is rarely encountered in clinical practice, especially without the presence of other factors that could provoke venous thromboembolism and is commonly associated with stroke. It is characterized by lower incidences of central pulmonary embolism and right ventricular dilation and by a lower rate of adverse outcomes due to pulmonary embolism itself.

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Chlamydia pneumoniae IgG seropositivity and risk of deep-vein thrombosis

Cited by 19 publications

References 8 publications

Infection and venous thrombosis

Infection and venous thrombosis

Chlamydia pneumoniae in infrequently examined blood vessels

Clinical characteristics of pulmonary embolism with concomitant pneumonia

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