Chlamydia pneumoniae Seropositivity and Systemic and Renovascular Atherosclerotic Disease

Ven, Andre J. A. M. van der; Hommels, M J; Kessels, Anton; Flobbe, Karin; Engelshoven, Jos van; Bruggeman, C. A.; Leeuw, Peter W. de

doi:10.1001/archinte.162.7.786

Cited by 10 publications

(2 citation statements)

References 26 publications

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“…A meta‐analysis of six studies found an adjusted odds ratio of only 1.2 (95% confidence interval, 1.0–1.5) for the development of CAD in seropositive subjects. 12 Seropositivity to C. pneumoniae is highly prevalent within the general population (up to 70% even in the absence of atherosclerosis), 13 diminishing the utility of antibody testing. Traditionally, seropositivity has been defined as ≥1:8 or ≥1:16.…”

Section: Potential Role Of Infection In Atherogenesismentioning

confidence: 99%

The Role of Infection in the Pathogenesis of Cardiovascular Disease

Zebrack

Anderson

2003

Progress Cardiovascular Nurs

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Atherosclerosis is a complex, multifactorial disease. Recently, research has intensified to identify the role of various infections in the pathogenesis of atherosclerosis. Specific agents have been proposed as direct initiators or accelerators of atherosclerosis, while other infectious agents have been proposed as accelerators of atherosclerosis through nonspecific stimulation of the inflammatory cascade. Recently, the total pathogen burden concept has suggested that while each specific infection contributes only slightly to the pathogenesis of atherosclerosis, the cumulative effects of infectious agents contribute greatly. Several randomized trials evaluating antibiotic therapy in the prevention of cardiovascular events have now been completed, although results have been conflicting. This manuscript summarizes current understanding of the role of infectious agents as a trigger of inflammation, as a contributor to atherosclerosis, and the potential role of antibiotic therapy in the treatment of atherosclerosis.

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Section: Potential Role Of Infection In Atherogenesismentioning

confidence: 99%

The Role of Infection in the Pathogenesis of Cardiovascular Disease

Zebrack

Anderson

2003

Progress Cardiovascular Nurs

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“…14 Possible mechanisms involved are (1) hypertrophy and proliferation of the smooth muscle cells and (2) a pathologically modified extracellular matrix. 15,16 Studies investigating the association between C pneumoniae and hypertension reported increased antichlamydial antibodies among hypertensive patients with atherosclerosis and renovascular disease or severe essential hypertension; 17,18 however, in a large prospective trial, no significant interrelationship was found. 19 The influence of age on IMT was similarly strong in our general population survey.…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic Carotid Atherosclerosis Is Associated With Circulating Chlamydia pneumoniae DNA in Younger Normotensive Subjects in a General Population Survey

Mitüsch¹,

Luedemann²,

Wood³

et al. 2005

ATVB

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Objective-Chlamydia pneumoniae infection has been associated with atherosclerosis, but serodiagnosis is unreliable in predicting vascular infection. Direct detection of circulating chlamydial DNA in peripheral blood mononuclear cells (PBMCs) was thus evaluated as a marker for cardiovascular risk in a general population survey using the common carotid intima-media thickness (IMT) as surrogate marker of asymptomatic atherosclerosis. Methods and Results-C pneumoniae DNA in PBMCs was determined by nested polymerase chain reaction and associated with IMT for 1032 healthy participants of a general population survey who were within the highest or lowest IMT distribution quartile. C pneumoniae DNA was more prevalent in those with increased IMT (13.4% versus 10.7%), but this was not significant in univariate and of borderline significance in multivariate analysis. Testing for potential effect modifications by known strong determinants of an increased IMT in group interaction analysis revealed an independent association between C pneumoniae DNA and IMT in normotensive subjects (odds ratio

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Chlamydia pneumoniae Infection: Which Role in Atherosclerosis?

Gabrielli¹

2002

Archives of Internal Medicine

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Chlamydia pneumoniae Seropositivity and Systemic and Renovascular Atherosclerotic Disease

Abstract: The presence of antibodies to C pneumoniae was significantly associated with atherosclerosis and renovascular disease in hypertensive patients in whom a renal artery stenosis was strongly suspected.

Cited by 10 publications

References 26 publications

The Role of Infection in the Pathogenesis of Cardiovascular Disease

The Role of Infection in the Pathogenesis of Cardiovascular Disease

Asymptomatic Carotid Atherosclerosis Is Associated With Circulating Chlamydia pneumoniae DNA in Younger Normotensive Subjects in a General Population Survey

Chlamydia pneumoniae Infection: Which Role in Atherosclerosis?

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