Chlamydia psittaci inclusion membrane protein CPSIT_0842 induces macrophage apoptosis through MAPK/ERK-mediated autophagy

Huang, Ying‐Hsien; Li, Sijia; He, Sirong; Li, Yumeng; He, Qing; Wu, Yimou

doi:10.1016/j.biocel.2023.106376

Cited by 3 publications

(1 citation statement)

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“…An Inc protein subset connects with specific host factors at the endoplasmic reticulum (ER)-inclusion membrane contact site (MCS) [ 23 ]. The Incs CPSIT_0842 induces macrophage apoptosis, which may help C. psittaci to evade the host innate immune response and establish persistent infections [ 24 ]. Further, CPSIT_0842 upregulates the expression of IL-6 and IL-8 via Toll-like receptor (TLR) 2- and 4-mediated MAPK and NF-κB signaling pathways in human monocytes [ 25 ].…”

Section: The Pathogenmentioning

confidence: 99%

Psittacosis: An Underappreciated and Often Undiagnosed Disease

Dembek,

Mothershead,

Owens

et al. 2023

Pathogens

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The bacterial agent Chlamydia psittaci, and the resulting disease of psittacosis, is a little-known and underappreciated infectious disease by healthcare practitioners and in public health in general. C. psittaci infections can cause significant psittacosis outbreaks with pandemic potential, with person-to-person transmission being documented in the last decade. In this publication, we review the pathogen and its disease, as well as examine the potential for genetic manipulation in this organism to create a more deadly pathogen. Recent disease surveys indicate that currently, the highest incidences of human disease exist in Australia, Germany and the UK. We recommend the universal public health reporting of C. psittaci and psittacosis disease and increasing the promotion of public health awareness.

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Section: The Pathogenmentioning

confidence: 99%