Chlamydia trachomatis and human herpesvirus 6 infections in ovarian cancer—Casual or causal?

Gulve, Nitish; Rudel, Thomas

doi:10.1371/journal.ppat.1008055

Cited by 6 publications

(9 citation statements)

References 32 publications

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“…There are several reports on anticancer-antimicrobial dual therapeutic effect, which can be for instance found in the review of Alibek et al [24]. It is well-known that various infections may take role in initiation and progression of diseases [25]. On the other hand, it is also known that chemotherapeutics commonly weaken the immune system.…”

Section: Pharmacological Activity Of the Complexes 1-8mentioning

confidence: 99%

Comparison of Solution Chemical Properties and Biological Activity of Ruthenium Complexes of Selected β-Diketone, 8-Hydroxyquinoline and Pyrithione Ligands

et al. 2021

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In this work, the various biological activities of eight organoruthenium(II) complexes were evaluated to reveal correlations with their stability and reactivity in aqueous media. Complexes with general formula [Ru(η6-p-cymene)(X,Y)(Z)] were prepared, where (X,Y) represents either an O,O-ligand (β-diketone), N,O-ligand (8-hydroxyquinoline) or O,S-pyrithione-type ligands (pyrithione = 1-hydroxypyridine-2(1H)-thione) with Cl‒ or 1,3,5-triaza-7-phosphaadamantane (PTA) as a co-ligand (Z). The tested complexes inhibit the chlamydial growth on HeLa cells, and one of the complexes inhibits the growth of the human herpes simplex virus-2. The chlorido complexes with N,O- and O,S-ligands displayed strong antibacterial activity on Gram-positive strains including the resistant S. aureus (MRSA) and were cytotoxic in adenocarcinoma cell lines. Effect of the structural variation on the biological properties and solution stability was clearly revealed. The decreased bioactivity of the β-diketone complexes can be related to their lower stability in solution. In contrast, the O,S-pyrithione-type complexes are highly stable in solution and the complexation prevents the oxidation of the O,S-ligands. Comparing the binding of PTA and the chlorido co-ligands, it can be concluded that PTA is generally more strongly coordinated to ruthenium, which at the same time decreased the reactivity of complexes with human serum albumin or 1-methylimidazole as well as diminished their bioactivity.

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Section: Pharmacological Activity Of the Complexes 1-8mentioning

confidence: 99%

Comparison of Solution Chemical Properties and Biological Activity of Ruthenium Complexes of Selected β-Diketone, 8-Hydroxyquinoline and Pyrithione Ligands

et al. 2021

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“…It has been proposed that delayed hypersensitivity and/or molecular mimicry in response to Chlamydia heat shock protein 60kDA (HSP60) may also result in fibrosis and potentially effect implantation of the pregnancy, but the evidence is conflicting [2]. As an obligate intracellular bacteria, CT modifies the host cell environment in order to persist through secretion of proteins into the cytosol which also have a potential pro-oncogenic effect [11,32]. CT infection not only inhibits apoptosis but also, through the production of reactive oxygen species, induces oxidative damage of DNA, the repair of which is also impaired by down regulation of base excision repair and nucleotide excision pathways which will eventually result in double strand breaks in DNA [11,[32][33][34][35].…”

Section: Chlamydia Infection Persistence and Inflammationmentioning

confidence: 99%

“…As an obligate intracellular bacteria, CT modifies the host cell environment in order to persist through secretion of proteins into the cytosol which also have a potential pro-oncogenic effect [11,32]. CT infection not only inhibits apoptosis but also, through the production of reactive oxygen species, induces oxidative damage of DNA, the repair of which is also impaired by down regulation of base excision repair and nucleotide excision pathways which will eventually result in double strand breaks in DNA [11,[32][33][34][35]. Telomeres, the protective caps on chromosomes, are also damaged [11,36].…”

Section: Chlamydia Infection Persistence and Inflammationmentioning

confidence: 99%

“…CT infection not only inhibits apoptosis but also, through the production of reactive oxygen species, induces oxidative damage of DNA, the repair of which is also impaired by down regulation of base excision repair and nucleotide excision pathways which will eventually result in double strand breaks in DNA [11,[32][33][34][35]. Telomeres, the protective caps on chromosomes, are also damaged [11,36]. Thus, persistent CT infection through DNA damage and impaired repair has the potential to induce genomic instability and thus create a pro-oncogenic environment [11].…”

Section: Chlamydia Infection Persistence and Inflammationmentioning

confidence: 99%

“…Such a state is not only pro-inflammatory but also pro-oncogenic and the associated cell surface receptor changes in the Fallopian tube could predispose to ectopic embryo attachment even in the absence of tubal scarring. [7][8][9][10][11]. In addition, it is now believed that most highgrade serous ovarian cancers (HGSCs) originate in the distal Fallopian tube epithelium and then spread to the ovary and throughout the abdomen.…”

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confidence: 99%

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Is There a Hidden Burden of Disease as a Result of Epigenetic Epithelial-to-Mesenchymal Transition Following Chlamydia trachomatis Genital Tract Infection?

Horner

Flanagan

Horne

2021

The Journal of Infectious Diseases

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Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection worldwide, has been widely researched for its involvement in many disease pathologies in the reproductive tract, including pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility. Recent findings, through the efforts to understand the pathogenesis of CT, suggest that CT can induce the process of epithelial-to-mesenchymal transition (EMT) through epigenetic changes in the epithelium of the female reproductive tract. This literature review aims to analyze the evidence for CT’s ability to promote EMT and to pinpoint the areas that merit further investigation.

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Most Relevant Genetic, Hormonal, and Environmental Factors in Ovarian Cancer Development – A Literature Review

Florczak,

Królikowska,

Mazurek

et al. 2024

Preprint

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Ovarian cancer (OC) represents a significant challenge in the realm of gynecological cancers, characterized by poor survival rates and complex etiology. In this review, we delve into the se-lected genetic, environmental, and hormonal factors underpinning OC development. We have reviewed scientific databases searching for ovarian cancer genetic and epigenetic factors. We have included studies based on their relevancy. As a result of exploring ovarian carcinogen-esis, this systematic review contains data collected from 126 various works. The role of prominent genetic players such as BRCA mutations, DNA repair mechanisms, un-derscores the intricate landscape of OC susceptibility. We explore Li-Fraumeni and Lynch syn-drome, which impart a heightened predisposition to OC development. Hormonal factors such as estrogen, progesterone, and androgens are also discussed. Environmental alterations, ranging from lifestyle influences on OC to microbiome dysbiosis and lifestyle factors such as obesity, al-cohol consumption, and physical activity intersect with genetic and epigenetic pathways, shaping the risk landscape for OC. Through a meticulous examination of current literature, this review provides a nuanced under-standing of the multifactorial nature of OC, emphasizing the need for holistic approaches to prevention, diagnosis, and treatment.

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Chlamydia trachomatis and human herpesvirus 6 infections in ovarian cancer—Casual or causal?

Cited by 6 publications

References 32 publications

Comparison of Solution Chemical Properties and Biological Activity of Ruthenium Complexes of Selected β-Diketone, 8-Hydroxyquinoline and Pyrithione Ligands

Comparison of Solution Chemical Properties and Biological Activity of Ruthenium Complexes of Selected β-Diketone, 8-Hydroxyquinoline and Pyrithione Ligands

Is There a Hidden Burden of Disease as a Result of Epigenetic Epithelial-to-Mesenchymal Transition Following Chlamydia trachomatis Genital Tract Infection?

Most Relevant Genetic, Hormonal, and Environmental Factors in Ovarian Cancer Development – A Literature Review

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