2017
DOI: 10.1248/cpb.c17-00061
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Chloramine-T-Mediated Oxidation of Benzylic Alcohols Using Indium(III) Triflate

Abstract: The efficient oxidation of benzylic alcohols to carbonyl compounds was performed using chloramine-T and a catalytic amount of indium(III) triflate. The primary benzylic alcohols were converted to the corresponding aldehydes in a good yield, and the secondary benzylic alcohols were oxidized to ketones in a high yield. The optimized reaction conditions required 0.3 eq of indium(III) triflate and the use of acetonitrile as a solvent.

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“…The role of metal catalysis in CT-induced oxidation of small organic substrates has been examined previously, e.g., for Os­(VIII) oxide and In­(III) triflate. , However, there seems to be no prior work related to the reactivity of CT in the presence of Fe or heme. We consider it most likely that the heme-catalyzed Lys oxidation seen here involves OCl – .…”
Section: Discussionmentioning
confidence: 99%
“…The role of metal catalysis in CT-induced oxidation of small organic substrates has been examined previously, e.g., for Os­(VIII) oxide and In­(III) triflate. , However, there seems to be no prior work related to the reactivity of CT in the presence of Fe or heme. We consider it most likely that the heme-catalyzed Lys oxidation seen here involves OCl – .…”
Section: Discussionmentioning
confidence: 99%