Chloramphenicol‐dependent antibody: a case report

Abstract

This case is an additional example of a chloramphenicol-dependent antibody. It demonstrates how the laboratory investigation of drug-related phenomena is dependent on testing the drug from that reacts in vivo.

In vitro reactions with red blood cells that are not due to blood group antibodies: a review

“…In contrast, neomycin, chloramphenicol, and gentamicin do not seem to bond covalently to RBC membranes and are easily washed away. The reports of ABO grouping problems due to these antibiotics [3][4][5][6][7] suggest that the in vitro reactions parallel those described for the drugs reacting by the so-called "immune complex" mechanism. 2,8,9 That is to say, the reactions are seen only when the patient's serum, containing the antibody, is added to RBCs in the presence of the antibiotic (i.e., in the commercial RBC suspension medium).…”

“…Most media contain chloramphenicol and neomycin sulfate, but some manufacturers add gentamicin, tetracycline, or streptomycin. Antibodies to any of these antibiotics can be present in a patient's serum, 2 but only antibodies to neomycin, 3 chloramphenicol, [4][5][6] In vitro reactions with red blood cells that are not due to blood group antibodies: a review G. GARRATTY and gentamicin 7 have been described, so far, as causing a problem with blood typing.…”

Streptomycin‐dependent panagglutinin causing error in forward blood grouping

“…Several antibiotics added to the red cell preservative solutions were responsible for false reverse grouping or antibody screening in the patients with antibodies to corresponding antibiotics [3–5]. Although streptomycin has not been previously implicated as a cause of false grouping, Martinez et al .…”