Chloramphenicol-Induced Aplastic Anemia Terminating with Acute Nonlymphocytic Leukemia

Schmitt‐Gräff, Annette

doi:10.1159/000207133

Cited by 14 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chloramphenicol has long been known to cause aplastic anemia, 34 and suspected on clinical grounds to be associated with adult leukemia, particularly ANLL. 35,6 The negative results in our epidemiologic study may be due to a weak leukemogenic effect of chloramphenicol (requiring a larger sample size), a lower sensitivity of adults than children tO the drugs, or perhaps a greater impact of recall bias among adults.…”

Section: Discussionmentioning

confidence: 87%

Prior medical conditions and the risk of adult leukemia in Shanghai, People's Republic of China

Zheng

Linet

Shu

et al. 1993

Cancer Causes Control

View full text Add to dashboard Cite

A population-based case-control interview study of 486 adult leukemia cases and 502 healthy controls was carried out in Shanghai, People's Republic of China during 1987-89 to evaluate the etiologic role of prior medical conditions, medications, and diagnostic X-rays. Risks were examined separately for 236 cases with acute non-lymphocytic leukemia (ANLL), 79 with chronic myeloid leukemia (CML), 81 with acute lymphocytic leukemia (ALL), and 21 with chronic lymphocytic leukemia (CLL). Little difference was found between cases and controls for prior history of diabetes, hypertension, allergic conditions, most medications, and diagnostic X-rays. A few significant associations were observed for appendectomy, tuberculosis, and for several other chronic disorders with specific leukemia cell types, but the odds ratio estimates for most of these ranged from two to three and, with the exception of the two specified above, were based generally on five or fewer exposed controls. In contrast to an association with childhood leukemia in Shanghai, prior use of chloramphenicol was not linked with ANLL or other forms of adult leukemia. Further research is needed to clarify the relation of specific medical conditions and exposures with particular subtypes of leukemia, and to examine reasons for the low incidence of CLL in China and other Asian populations.

show abstract

Section: Discussionmentioning

confidence: 87%

Prior medical conditions and the risk of adult leukemia in Shanghai, People's Republic of China

Zheng

Linet

Shu

et al. 1993

Cancer Causes Control

View full text Add to dashboard Cite

show abstract

“…24 Chloramphenicol (CAP) is a broad-spectrum antibiotic that inhibits a variety of aerobic and anaerobic microorganisms. 25 It is highly effective in agricultural, veterinary and aquaculture practice, [26][27][28] but it causes many adverse effects such as bone marrow suppression, [29][30][31] aplastic anemia, 32,33 leukemia 34 and gray baby syndrome. 35 Bone marrow hematopoiesis is impaired when more than 1 mg kg À1 CAP remains in animal tissues.…”

Section: Introductionmentioning

confidence: 99%

Transmembrane distribution of kanamycin and chloramphenicol: insights into the cytotoxicity of antibacterial drugs

Song

Gao

2010

Mol. BioSyst.

View full text Add to dashboard Cite

Antibiotics are widely used and their abuse has caused ecological hazard. Recently, pollution from pharmaceuticals and personal care products (PPCPs) has aroused great concern among governments and researchers. In order to elucidate the correlations among molecular structure, transmembrane distribution and toxicological effects of different kinds of antibiotics, zebrafish (Danio rerio) embryos and larvae were exposed to two structurally different antibiotics, kanamycin (KAN) and chloramphenicol (CAP). The membrane distribution and toxicological effects of these antibiotics were investigated. The association of KAN with the embryos fitted a general Langmuir isotherm and was attributed to electrostatic attraction and hydrogen bond formation. The saturation number of KAN is 252 +/- 13 nmol per embryo and the adsorption constant (5.24 +/- 0.05) x 10(3) L mol(-1). The interaction of CAP with the embryos conformed to a general model of partitioning behavior with the partition coefficient being 14.20 +/- 0.94 microL per embryo, and was attributed to hydrophobic effects. More than 89% of the adsorbed KAN was located on the outer surface of the embryonic chorion, but over 80% of the adsorbed CAP entered the internal matrix. High antibiotic concentrations were lethal to most embryos, while low concentrations were teratogenic. KAN and CAP had different transmembrane distribution and their toxicities differed in character. KAN mainly accumulated on the outer membrane caused e.g. axial malformation (AM). In contrast, CAP readily went through the membrane into the cytoplasm and caused e.g. serious pericardial edema (PE), yolk sac edema (YSE) and hemagglutination (HE). The new method could be useful for evaluating the interactions of toxins with membranes and elucidating the mechanisms of cytotoxicity.

show abstract

Chloramphenicol 56-75-7

2004

Sax's Dangerous Properties of Industrial Materials

View full text Add to dashboard Cite

Chloramphenicol-Induced Aplastic Anemia Terminating with Acute Nonlymphocytic Leukemia

Cited by 14 publications

References 5 publications

Prior medical conditions and the risk of adult leukemia in Shanghai, People's Republic of China

Prior medical conditions and the risk of adult leukemia in Shanghai, People's Republic of China

Transmembrane distribution of kanamycin and chloramphenicol: insights into the cytotoxicity of antibacterial drugs

Chloramphenicol 56-75-7

Contact Info

Product

Resources

About