Chlorhexidine alcohol base mouthrinse versus Chlorhexidine formaldehyde base mouthrinse efficacy on plaque control: Double blind, randomized clinical trials

Abstract

Background: Chlorhexidine is well known for its antiplaque effect. However, the mouthrinse based chlorhexidine antiplaque efficiency may vary according to the formulation of the final product. The aim of the present study was to compare anti-plaque effectiveness of two commercial mouthrinses: 0.12 % Chlorhexidine alcohol base (CLX-A) versus a diluted 0.1% Chlorhexidine non-alcohol base with 0.1% of Formaldehyde (CLX-F). Material and Methods: the study was a seven day randomized, double-blind, placebo-controlled trial including 30 volunteers. At the start, all participants received a dental prophylaxis. Over 7 days experimental non-brushing period, during which subjects abstained from all forms of mechanical oral hygiene, one group test rinsed twice daily with 15ml of an alcohol base 0.12% Chlorhexidine mouthrinse. The second group test used 15ml of alcohol free 0.1% Chlorhexidine mouthrinse base 0.1% formaldehyde twice daily. The negative control group used a placebo. Plaque indexes were recorded in all volunteers prior to treatment at Day 0, 1 and 7. Results: After 7 days, the mean plaque index for the first group was 0.76±0.38 compared with a mean plaque index of 1.43±0.56 for the second group. The difference in plaque scores between the groups was statistically significant. Conclusion: the results of this study showed that rinsing with an alcohol base 0.12% Chlorhexidine mouthrinse is significantly different from rinsing with an alcohol free 0.1% Chlorhexidine mouthrinse on plaque inhibition. Key words:Chlorhexidine, dental plaque, mouthrinse, alcohol, formaldehyde.

Antimicrobial potential and gustatory perception of chlorhexidine gluconate mouthwashes with or without alcohol after a single rinse – a randomized controlled crossover clinical trial

“…In the literature, it is controversial the results of efficacy studies with mouthwashes with or without alcohol. Studies showed that the alcohol enhanced the antimicrobial effects of the chlorhexidine mouthwash , on the other hand, another study found no difference between those mouthwashes , which is in accordance with the present study. Those results support the industry approach of taking out the market of the mouthwashes with alcohol.…”

Commercial antimicrobials mouthrinses on caries and periodontitis-related biofilm control: a review of literature

“…After the treatment, plaque indexes were recorded. The mean plaque of first group (0.76±0.38) was significantly lower compared to the second group (1.43±0.56), showing that alcohol might have some influence on the antiplaque effect of CHX [35].…”

Comparison Of Full-Mouth Scaling and Quadrant-Wise Scaling in the Treatment of Adult Chronic Periodontitis

“…Several were the methodologies regarding the use of rinses in every mouth disinfection therapy. Were evaluated individuals using rinses: chlorhexidine for two months (1,3,4), chlorhexidine for 2 weeks, mouthrinse with essential oils (2), without the use of any substance (19) and support antibiotics with associated (11,22). Because of the unique characteristics of chlorhexidine 0.12%, and respecting the limits on the use of the substance chose the use of protocol for seven days, and the results show similarities with other studies (1,4) when the use of chlorhexidine for two months.…”

“…Chlorhexidine is an effective oral antiseptic agent, that has proven antimicrobial effect and when used in a rational way can be an important tool in controlling periodontal disease (11). Prolonged use of chlorhexidine may cause numerous side effects, such as the presence of stains on tooth surfaces and change in taste (12), mucosal irritation, and burning sensations in the mucosa (13).…”