Chlorhexidine prophylaxis for chemotherapy-and radiotherapy-induced stomatitis: A randomized double-blind trial

Ferretti, Gerald A.; Raybould, Ted P.; Brown, Albert T.; Macdonald, John S.; Greenwood, Martha F.; Maruyama, Yosh; Geil, John D.; Lillich, Thomas T.; Ash, Robert C.

doi:10.1016/0030-4220(90)90295-4

Cited by 166 publications

(98 citation statements)

References 16 publications

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“…However, although chlorhexidine presents excellent antimicrobial properties such as low-concentration efficiency, substantivity, minimal perception by the gastrointestinal tract, capacity to reduce biofilm formation and disorganize pre-formed biofilm, 22,[25][26][27] it also presents some side effects, including mild discomfort or burning sensation when chlorhexidine comes in contact with the oral mucosa, in addition to epithelium exfoliation, teeth staining, enhance- A ment of supragingival calculus and color alteration of artificial teeth and denture basis. 22,23,25,28 Thus, there is a need to research alternative disinfecting solutions, aiming at minimizing the side effects of disinfecting solutions to the physical-chemical properties of dentures and to the patient's health.…”

Section: Discussionmentioning

confidence: 99%

Effect of sodium bicarbonate on Candida albicans adherence to thermally activated acrylic resin

et al. 2009

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The purpose of this study was to evaluate the effect of 5% sodium bicarbonate on the adherence of Candida albicans to thermally activated acrylic resin. Fifty 4 mm² specimens of acrylic resin were obtained using a metallic matrix. The specimens received chemical polishing, were sterilized and then immersed in Sabouraud broth, inoculated with Candida albicans standardized suspension. After 24 hours of incubation at 37°C, the specimens were divided into four groups according to the substance used for disinfection (5% sodium bicarbonate, 0.12% digluconate chlorhexidine, vinegar and Corega Tabs). A control group was included, in which distilled water was used. The adhered microorganisms were dispersed, diluted and plated onto culture media to determine the number of colony-forming units (cfu/mL). The results were analyzed through the Mann-Whitney statistical test at the 5% level of significance. Only 0.12% digluconate chlorhexidine and 5% sodium bicarbonate presented a statistically significant difference (p = 0.0010 and p = 0.0156, respectively) compared to the control group, decreasing the number of cfu/mL. However, when the different disinfecting solutions were compared with each other, only 0.12% digluconate chlorhexidine presented a statistically significant difference in the reduction of cfu/mL. It was concluded that although 0.12% digluconate chlorhexidine was more effective in the reduction of Candida albicans adherence values to thermally activated acrylic resin, 5% sodium bicarbonate also proved to be a viable alternative.

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Section: Discussionmentioning

confidence: 99%

Effect of sodium bicarbonate on Candida albicans adherence to thermally activated acrylic resin

et al. 2009

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“…Therefore, many prophylactic regimens aimed at the prevention of oral infection by using different anti-infective mouth rinses. [19][20][21][22][23][24][25] The anti-infectives used in our study, that is, PVP, chlorhexidine, polyenes, and sage tea, have been examined in previous clinical trials. Some of these trials examined their effectiveness in preventing or alleviating mucositis.…”

Section: Discussionmentioning

confidence: 99%

“…21,24 Other investigators evaluated the effect of mouth rinses on the bacterial and fungal colonization of the oral cavity. 19,20,26 The aim of this study was to assess whether a combination of local and systemic anti-infectives has the potential to reduce the oral microbial burden.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies found a reduction of potential pathogens, 19 and others an increase of gramnegative bacterial counts. 20,22 A Cochrane analysis did not find chlorhexidine to be effective in the prevention of mucositis. 28 Another prophylactic approach is the use of a combination of amphotericin B, polymyxin B, and tobramycin given either as a paste 29 or as lozenges.…”

Section: Discussionmentioning

confidence: 99%

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Failure of anti-infective mouth rinses and concomitant antibiotic prophylaxis to decrease oral mucosal colonization in autologous stem cell transplantation

Lövenich¹,

Schütt-Gerowitt²,

Keulertz³

et al. 2005

Bone Marrow Transplant

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Summary:Autologous stem cell transplantation has augmented treatment successes. However, high-dose chemotherapy is still accompanied by dose-limiting toxicities, for example, severe mucositis. Mucosal lesions serve as portals of entry for infections. In order to reduce the oral microbial burden, we prospectively evaluated the microbiological impact of a complex regimen of mouth rinses consisting of concomitantly applied polyene antifungals, povidone-iodine, chlorhexidine, sage tea, and prophylactic ciprofloxacin and fluconazole. A total of 15 patients were enrolled into this longitudinal evaluation. Colony-forming units (CFU) were quantitated from saliva, buccal and palatinal swabs during high-dose chemotherapy and autologous stem cell transplantation. The number of CFU did not show any significant changes after initiation of the mouth rinses and the prophylactic antibiotics. The median CFU count was 268 Â 10 6 /ml saliva before chemotherapy and decreased after initiation of intravenous antibiotics only. Neither prophylactic nor therapeutic antifungals significantly reduced the number of cultures positive for yeasts. Since 90% of our patients had febrile neutropenia at some time point during the observation period, the approach evaluated cannot be recommended as prophylaxis of febrile neutropenia as such.

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“…The safety of the use of solutions as chlorhexidine, sodium hypochlorite, vinegar and hydrogen peroxide is reported in the literature [16][17][18][19][20][21][22][23][24] . They presented biocompatibility and low cytotoxicity when used in low concentrations being safe for denture chemical disinfection.…”

Section: Introductionmentioning

confidence: 99%

Effect of affordable disinfectant solutions on Candida albicans adhered to acrylic resin for dental prosthesis

Hashizume

Hoscharuk

Moreira

2015

RGO, Rev. Gaúch. Odontol.

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ObjectiveTo evaluate the effect of different low-cost disinfectant solutions on Candida albicans (C. albicans) adhered to acrylic resin used in dental prosthesis. Methods Sixty acrylic resin specimens were divided into four experimental groups according to the disinfecting agent tested (2% chlorhexidine, 1% sodium hypochlorite, vinegar and 10v hydrogen peroxide) and two control groups. Fifty specimens were incubated with C. albicans and after immersed in the disinfecting solutions or saline (negative control). Specimens without contamination constituted the positive control group. After disinfection procedures, all specimens were immersed in a culture medium and incubated for 24 hours at 37°C. Culture media turbidity was evaluated. Results The disinfectants 2% chlorhexidine and 1% sodium hypochlorite performed a maximal reduction of C. albicans. Vinegar showed intermediate antifungal effect and 10v hydrogen peroxide showed a lower effect.Conclusions Among the disinfecting solutions tested in the present study, 2% chlorhexidine and 1% sodium hypochlorite are the most effective in the reduction of C. albicans adhered to acrylic resin. However, vinegar may represent a viable and low-cost alternative to prosthesis disinfection.

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Chlorhexidine prophylaxis for chemotherapy-and radiotherapy-induced stomatitis: A randomized double-blind trial

Cited by 166 publications

References 16 publications

Effect of sodium bicarbonate on Candida albicans adherence to thermally activated acrylic resin

Effect of sodium bicarbonate on Candida albicans adherence to thermally activated acrylic resin

Failure of anti-infective mouth rinses and concomitant antibiotic prophylaxis to decrease oral mucosal colonization in autologous stem cell transplantation

Effect of affordable disinfectant solutions on Candida albicans adhered to acrylic resin for dental prosthesis

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