Chlorhexidine release from room temperature polymerising methacrylate systems

Riggs, P.D.; Braden, M.; Patel, Mukesh R.

doi:10.1016/s0142-9612(99)00187-8

Cited by 95 publications

(70 citation statements)

References 11 publications

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“…The results of in vitro susceptibility tests indicated that the antibacterial activity of DMAE-CB was similar to that of CHX. However, many studies have reported that CHX can be released in relatively high amounts from various methacrylate polymers and bone cements (25)(26)(27), whereas DMAE-CB can be chemically bound within the polymer carrier via a polymerizable group (methacryloyl group) for possible long-term effectiveness.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial effects of three experimental quaternary ammonium salt (QAS) monomers on bacteria associated with oral infections

et al. 2008

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The aim of this study was to test the antibacterial effects of three experimental quaternary ammonium salt monomers in order to evaluate their potential applications as dental materials. In vitro susceptibility testing of the monomers was performed by the broth dilution method on bacteria associated with oral infections: Streptococcus mutans ATCC 25175, Actinomyces viscosus ATCC 15987, Staphylococcus aureus ATCC 29213 and Lactobacillus casei ATCC 393. The time-kill kinetics of the monomer with relatively higher antibacterial activity against S. mutans were also investigated. It was found that all the tested bacteria strains were susceptible to the three monomers, among which methacryloxylethyl cetyl ammonium chloride (DMAE-CB) exhibited the lowest minimal inhibitory concentrations, ranging from 1.2 to 4.8 µg/ml. The time-kill curve showed that DMAE-CB achieved 99.44% killing at 19.2 µg/ml (4 times the minimal bactericidal concentration) against S. mutans after 1 min and 100% killing within 10 min of contact. This result indicates that the quaternary ammonium salt monomer DMAE-CB may be a candidate antibacterial agent for incorporation into dental restorative materials. (J. Oral Sci. 50, [323][324][325][326][327] 2008) Keywords: quaternary ammonium salt; antibacterial effect; oral pathogenic bacteria; monomer; dental material.

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Section: Discussionmentioning

confidence: 99%

Antibacterial effects of three experimental quaternary ammonium salt (QAS) monomers on bacteria associated with oral infections

et al. 2008

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“…Additionally, distilled water was replaced at set times (1, 3, 6, 9, 12, 36, and 48 h). All procedures were performed at approximately 20ºC with stirring and were repeated four times 13) .…”

Section: Preparation Of the Elastomericsmentioning

confidence: 99%

Chlorhexidine-releasing orthodontic elastomerics

Jeon

Choi

Kang

et al. 2015

Dental Materials Journal

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The aim of this study was to identify the best combination of chlorhexidine (CHX) with orthodontic elastomerics for prevention of oral disease in orthodontic patients. We used ethyl cellulose (EC) as the polymer, and experimental groups were divided into five groups according to differences in solvent (i.e., ethanol; EtOH, dichloromethane; DCM). CHX release from the coated elastomerics was evaluated with a UV spectrophotometer and observed by scanning electron microscope (SEM). The antimicrobial release increased over time for 48 h in Group 3 (CDA+EC+30% EtOH/70% DCM), exhibiting the longest sustained-release characteristics (p<0.001). It also showed the highest antimicrobial properties, which was confirmed by inhibition zone testing using S. mutans (p<0.05). All groups were not affected when tensile force was tested in the coated elastomerics. We conclude that the antibacterial effect of CHX can be adjusted according to combinations of polymers and solvents. Group 3 exhibited the best substantivity and antimicrobial properties.

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“…A prolonged therapeutic effect can be achieved using such delivery systems whereby high conventional systemic doses can be replaced by slow local release of lower doses 4) . Several systems have been suggested to be used as intra-oral delivery devices 2,5) . These systems are predominantly based on polymethylmethacrylate (PMMA) 2,6) .…”

Section: Introductionmentioning

confidence: 99%

“…These systems are predominantly based on polymethylmethacrylate (PMMA) 2,6) . A number of bioactive delivery systems based on a cold-cure poly (ethyl methacrylate)/tetrahydrofurfuryl methacrylate (PEM/THFM) polymer system have been introduced with promising results 1,3,5,7) . This polymer can be used as a denture lining material or as a base for dental appliances.…”

Section: Introductionmentioning

confidence: 99%

“…There are some studies on its physical and chemical properties as well as biocompatibility [8][9][10] . It has been suggested that impregnating PEM/THFM with an antimicrobial such as chlorhexidine (CHX) may influence the polymerisation and the degree of conversion (DC) of the polymer which may have an adverse impact on its mechanical properties 5) . Ideal polymerisation of acrylic resins should result in conversion of all monomer into polymer.…”

Section: Introductionmentioning

confidence: 99%

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Impregnation with antimicrobials has an impact on degree of conversion and colour stability of acrylic liner

et al. 2012

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This study investigated the impact of impregnation of a poly(ethyl methacrylate) /tetrahydrofurfuryl methacrylate (PEM/THFM) polymer with chlorhexidine or fluconazole on the degree of conversion (DC) and colour stability (ΔE). The DC of uncured (0 h) and cured (24 h) samples was analysed by Fourier transform infrared spectroscopy (FTIR) and colour stability was analysed colorimetrically. The DC percentage of the control samples was significantly greater than those containing chlorhexidine and fluconazole (p≤0.05). The control discs exhibited only slight colour change compared to the impregnated discs which showed marked colour change (p≤0.05). A strong negative correlation between the extent of colour change and the degree of conversion was detected (r=0.97). The DC and colour stability were influenced by the addition of chlorhexidine or fluconazole. However, the final values were comparable to other commonly used acrylic liners and within acceptable ranges. PEM/THFM can be considered as a biocompatible drug delivery system.

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Chlorhexidine release from room temperature polymerising methacrylate systems

Cited by 95 publications

References 11 publications

Antibacterial effects of three experimental quaternary ammonium salt (QAS) monomers on bacteria associated with oral infections

Antibacterial effects of three experimental quaternary ammonium salt (QAS) monomers on bacteria associated with oral infections

Chlorhexidine-releasing orthodontic elastomerics

Impregnation with antimicrobials has an impact on degree of conversion and colour stability of acrylic liner

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