Chlorhexidine treatment for the prevention of dental caries in children and adolescents

Fedorowicz, Zbys; Pedrazzi, Vinícius; Oliveira-Neto, Jeronimo M; Shinkai, Rosemary Sadami Arai; Radhi, Ameera

doi:10.1002/14651858.cd008457

Cited by 1 publication

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the high incidence of dental caries around the globe and because prevention is highly dependent on individual collaboration, new therapies have been researched to control the pathogenic oral microflora and thus reduce the incidence of such lesions (Walsh et al 2015). One of the therapies that has received great visibility in the last year aims to use small molecules with high antibacterial activity and low cytotoxic activity, the antimicrobial peptides (AMPs) (Silva et al 2012;Kreling et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of a novel antimicrobial peptide [W7]KR12-KAEK derived from KR-12 against Streptococcus mutans planktonic cells and biofilms

et al. 2017

View full text Add to dashboard Cite

The aims of this study were to describe the synthesis of a novel synthetic peptide based on the primary structure of the KR-12 peptide and to evaluate its antimicrobial and anti-biofilm activities against Streptococcus mutans. The antimicrobial effect of KR-12 and [W]KR12-KAEK was assessed by determining the minimum inhibitory (MIC) and minimum bactericidal (MBC) concentrations. The evaluation of anti-biofilm activity was assessed through total biomass quantification, colony forming unit counting and scanning electron microscopy. [W]KR12-KAEK showed MIC and MBC values ranging from 31.25 to 7.8 and 62.5 to 15.6 μg ml, respectively. Furthermore, [W7]KR12-KAEK significantly reduced biofilm biomass (50-100%). Regarding cell viability, [W]KR12-KAEK showed reductions in the number of CFUs at concentrations ranging from 62.5 to 7.8 μg ml and 500 to 62.5 μg ml with respect to biofilm formation and preformed biofilms, respectively. SEM micrographs of S. mutans treated with [W]KR12-KAEK suggested damage to the bacterial surface. [W]KR12-KAEK is demonstrated to be an antimicrobial agent to control microbial biofilms.

show abstract

Section: Introductionmentioning

confidence: 99%