Chloride channel-3 is required for efficient tumour cell migration and invasion in human cervical squamous cell carcinoma

Guan, Yutao; Luan, Yi; Xie, Yong; Zhou, Hui; Liu, Weifeng; Zhang, Xiaolu; Shen, Xueyi; Chen, Yangping; Xu, Lijiang; Lin, Zhongqiu; Wang, Gang

doi:10.1016/j.ygyno.2019.03.006

Cited by 7 publications

(5 citation statements)

References 11 publications

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“…There are nine subtypes of the CLC channel family, where CLCN3 (CLC-3) expression is related to cell cycle regulation and cell proliferation, migration, and apoptosis [211,212] (Figure 2). In cervical squamous cell carcinoma, the CLCN3 channel is involved in cell invasion and migration processes and includes the participation of the PI3K/AKT/mTOR signaling pathway [94].…”

Section: Voltage-dependent Chloride Channelsmentioning

confidence: 99%

Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers

Chiliquinga,

Acosta,

Ogonaga-Borja

et al. 2023

Cells

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The human papilloma virus (HPV) group comprises approximately 200 genetic types that have a special affinity for epithelial tissues and can vary from producing benign symptoms to developing into complicated pathologies, such as cancer. The HPV replicative cycle affects various cellular and molecular processes, including DNA insertions and methylation and relevant pathways related to pRb and p53, as well as ion channel expression or function. Ion channels are responsible for the flow of ions across cell membranes and play very important roles in human physiology, including the regulation of ion homeostasis, electrical excitability, and cell signaling. However, when ion channel function or expression is altered, the channels can trigger a wide range of channelopathies, including cancer. In consequence, the up- or down-regulation of ion channels in cancer makes them attractive molecular markers for the diagnosis, prognosis, and treatment of the disease. Interestingly, the activity or expression of several ion channels is dysregulated in HPV-associated cancers. Here, we review the status of ion channels and their regulation in HPV-associated cancers and discuss the potential molecular mechanisms involved. Understanding the dynamics of ion channels in these cancers should help to improve early diagnosis, prognosis, and treatment in the benefit of HPV-associated cancer patients.

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Section: Voltage-dependent Chloride Channelsmentioning

confidence: 99%

Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers

Chiliquinga,

Acosta,

Ogonaga-Borja

et al. 2023

Cells

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“…In fact, they also found that cancer cells can express and secrete MMP-9 through this signal pathway to enhance the catabolism of extracellular matrix to achieve migration and invasion. 46 Similarly, Wang et al showed that ClC-3 can also increase the transcriptional activity of nuclear factor-κB (NF-κB) in cancer cells to upregulate the expression of MMP-3 and MMP-9, which can also promote malignant migration and invasion. 47 In addition, in several reports on the pathogenesis of endometriosis, it was found that ClC-3 can promote the abnormal metastasis and invasion of endometrial cells by mediating the upregulation of MMP-9.…”

Section: Abnormal Metabolism Of the Extracellular Matrix And Oamentioning

confidence: 99%

Chloride Channel and Inflammation-Mediated Pathogenesis of Osteoarthritis

Lin¹,

Deng²,

Liu³

et al. 2022

JIR

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Articular cartilage allows the human body to buffer and absorb stress during normal exercise. It is mainly composed of cartilage cells and the extracellular matrix and is surrounded by the extracellular microenvironment formed by synovial fluid and various factors in it. Studies have shown that chondrocytes are the metabolic center of articular cartilage. Under physiological conditions, the extracellular matrix is in a dynamic balance of anabolism and catabolism, and various factors and physical and chemical conditions in the extracellular microenvironment are also in a steady state. This homeostasis depends on the normal function of proteins represented by various ion channels on chondrocytes. In mammalian chondrocyte species, ion channels are mainly divided into two categories: cation channels and anion channels. Anion channels such as chloride channels have become hot research topics in recent years. These channels play an extremely important role in various physiological processes. Recently, a growing body of evidence has shown that many pathological processes, abnormal concentration of mechanical stress and chloride channel dysfunction in articular cartilage lead to microenvironment disorders, matrix and bone metabolism imbalances, which cause partial aseptic inflammation. These pathological processes initiate extracellular matrix degradation, abnormal chondrocyte death, hyperplasia of inflammatory synovium and bony. Osteoarthritis (OA) is a common clinical disease in orthopedics. Its typical manifestations are joint inflammation and pain caused by articular cartilage degeneration, but its pathogenesis has not been fully elucidated. Focusing on the physiological functions and pathological changes of chloride channels and pathophysiology of aseptic inflammation furthers the understanding of OA pathogenesis and provides possible targets for subsequent medication development.

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“…Interestingly, MMP9 appears to have a strong positive correlation with ClC-3, which regulates the extracellular environment and promotes the migration and invasion of cancer cells through multiple pathways of upregulation of MMP9 expression ( Guan et al, 2016 ; Wang et al, 2017 ; Guan et al, 2019 ). ClC-3 and ClC-5 are very similar in basic biophysical properties, both of them are expressed intracellularly in almost all cell types and have been shown by several studies to be actually Cl − /H + reverse transporter proteins, but ClC-3 is more widely distributed compared to ClC-5 ( Steinmeyer et al, 1995 ).…”

Section: Chloride Channelsmentioning

confidence: 99%

Ion channels as a therapeutic target for renal fibrosis

Yan

Fang

2022

Front. Physiol.

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Renal ion channel transport and electrolyte disturbances play an important role in the process of functional impairment and fibrosis in the kidney. It is well known that there are limited effective drugs for the treatment of renal fibrosis, and since a large number of ion channels are involved in the renal fibrosis process, understanding the mechanisms of ion channel transport and the complex network of signaling cascades between them is essential to identify potential therapeutic approaches to slow down renal fibrosis. This review summarizes the current work of ion channels in renal fibrosis. We pay close attention to the effect of cystic fibrosis transmembrane conductance regulator (CFTR), transmembrane Member 16A (TMEM16A) and other Cl− channel mediated signaling pathways and ion concentrations on fibrosis, as well as the various complex mechanisms for the action of Ca2+ handling channels including Ca2+-release-activated Ca2+ channel (CRAC), purinergic receptor, and transient receptor potential (TRP) channels. Furthermore, we also focus on the contribution of Na+ transport such as epithelial sodium channel (ENaC), Na+, K+-ATPase, Na+-H+ exchangers, and K+ channels like Ca2+-activated K+ channels, voltage-dependent K+ channel, ATP-sensitive K+ channels on renal fibrosis. Proposed potential therapeutic approaches through further dissection of these mechanisms may provide new therapeutic opportunities to reduce the burden of chronic kidney disease.

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Chloride channel-3 is required for efficient tumour cell migration and invasion in human cervical squamous cell carcinoma

Cited by 7 publications

References 11 publications

Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers

Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers

Chloride Channel and Inflammation-Mediated Pathogenesis of Osteoarthritis

Ion channels as a therapeutic target for renal fibrosis

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