Chloride Excretion During Glycosuria in Patients With Diabetes

Gabrilove, J. Lester

doi:10.1172/jci101703

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Glycosuria does not increase the uri nary excretion of chloride in patients without ketosis (261). "Amel lin," claimed to be antidiabetic (262), has since been reported to be ineffective in man and cats (263).…”

Section: Lukensmentioning

confidence: 99%

Metabolic Functions of the Endocrine Glands

Lukens¹

1947

Annu. Rev. Physiol.

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Section: Lukensmentioning

confidence: 99%

Metabolic Functions of the Endocrine Glands

Lukens¹

1947

Annu. Rev. Physiol.

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The Metabolism of Glucose and Electrolytes in Diabetic Acidosis 1

Seldin¹,

Tarail²

1950

J. Clin. Invest.

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Studies in Diabetes Mellitus. Ii. The Occurrence of a Diuresis in Diabetic Persons Exposed to Stressful Life Situations, With Experimental Observations on Its Relation to the Concentration of Glucose in Blood and Urine 1

Hinkle¹,

Edwards²,

Wolf³

et al. 1951

J. Clin. Invest.

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It has been known for many years that the administration of large amounts of glucose to persons with diabetes mellitus may lead to a diuresis. Recent work has amply demonstrated that this effect is attributable to the fact that in the presence of high concentrations of urinary glucose or any other solute there is a limit to the amount of water the renal tubule can absorb-a point where the osmotic pressure of the urine outweighs the work capacity of the tubular epithelium. Brodsky, Rapoport, and West (1) have shown that in this respect the kidney of the diabetic behaves toward glucose in the same manner as the kidney of the non-diabetic individual.However, there is an increasing body of evidence which suggests that not all of the polyuria which occurs in diabetic persons can be attributed to an increase in the amount of glucose excreted. For example, Tolstoi and Weber (2) all grades of severity, the present authors (4-7) have repeatedly observed an increase in water and glucose excretion, sometimes associated with ketosis and coma, occurring in association with stressful life situations, and not attributable to infection, trauma, or changes in diet, insulin, or activity. During short term experimental observations (8) it was found that such stresses may induce a marked increase in the ketonemia of both diabetic and non-diabetic persons and significant changes in their blood glucose levels, and that these metabolic changes are frequently accompanied by diuresis. Experimental investigation of this diuresis in non-diabetic persons (9) showed it to be characterized by an increase of up to 500%o in the rate of water excretion, accompanied by a fall in the specific gravity of the urine and in the concentration of chlorides and ketone bodies. The changes in the constituents of both the blood and the urine were found to be quite similar to those which take place during the diuresis which occurs during the early stages of a total fast.The present report describes the results of a study of the phenomenon of "stress diuresis" in persons with diabetes mellitus. METHODS

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Chloride Excretion During Glycosuria in Patients With Diabetes

Cited by 3 publications

References 4 publications

Metabolic Functions of the Endocrine Glands

Metabolic Functions of the Endocrine Glands

The Metabolism of Glucose and Electrolytes in Diabetic Acidosis 1

Studies in Diabetes Mellitus. Ii. The Occurrence of a Diuresis in Diabetic Persons Exposed to Stressful Life Situations, With Experimental Observations on Its Relation to the Concentration of Glucose in Blood and Urine 1

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