Chloride intracellular channel 4 participate in the protective effect of Ginkgolide B in MPP+ injured MN9D cells: insight from proteomic analysis

Feng, Zijian; Zhu, Zhi-Bin; Chen, Wang; Bai, Yueyu; Hu, Daihua; Cheng, Jia

doi:10.1186/s12014-020-09295-6

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…CLIC4 played a critical function in maintaining mitochondrial membrane potential in L929 cells depleted of mitochondrial DNA ( 65 ). More recently, mitochondrial CLIC4 has been implicated in two human diseases, ethylmalonic encephalopathy ( 66 ) and Parkinson’s disease ( 67 ). We showed that in the absence of CLIC4, intracellular superoxide and H 2 O 2 levels were elevated, there was a high ROS environment, and cells were vulnerable to additional prooxidant exposures.…”

Section: Discussionmentioning

confidence: 99%

The oxidoreductase CLIC4 is required to maintain mitochondrial function and resistance to exogenous oxidants in breast cancer cells

Khamici

Sanchez²,

Yan³

et al. 2022

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

The oxidoreductase CLIC4 is required to maintain mitochondrial function and resistance to exogenous oxidants in breast cancer cells

Khamici

Sanchez²,

Yan³

et al. 2022

Journal of Biological Chemistry

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“…Reports have shown that ginkgolides and sesquiterpene protect mitochondria from age-related damage and improve mitochondrial function and energy metabolism [ 26 , 27 , 28 ]. There are two possible molecular mechanisms for mitochondrial protection: antagonism of platelet-activating factor receptor (PAF, 1-O-alkyl-2-acetyl-sn-glycerol-3-phosphocholine) [ 29 , 30 , 31 ] and chloride channels [ 32 , 33 , 34 ]. More than 30 genuine flavonoids are found in ginkgo biloba.…”

Section: Introductionmentioning

confidence: 99%

Blending Technology Based on HPLC Fingerprint and Nonlinear Programming to Control the Quality of Ginkgo Leaves

Liu

Jin

et al. 2022

Molecules

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The breadth and depth of traditional Chinese medicine (TCM) applications have been expanding in recent years, yet the problem of quality control has arisen in the application process. It is essential to design an algorithm to provide blending ratios that ensure a high overall product similarity to the target with controlled deviations in individual ingredient content. We developed a new blending algorithm and scheme by comparing different samples of ginkgo leaves. High-consistency samples were used to establish the blending target, and qualified samples were used for blending. Principal component analysis (PCA) was used as the sample screening method. A nonlinear programming algorithm was applied to calculate the blending ratio under different blending constraints. In one set of calculation experiments, the result was blended by the same samples under different conditions. Its relative deviation coefficients (RDCs) were controlled within ±10%. In another set of calculations, the RDCs of more component blending by different samples were controlled within ±20%. Finally, the near-critical calculation ratio was used for the actual experiments. The experimental results met the initial setting requirements. The results show that our algorithm can flexibly control the content of TCMs. The quality control of the production process of TCMs was achieved by improving the content stability of raw materials using blending. The algorithm provides a groundbreaking idea for quality control of TCMs.

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Targeting the RUNX3–miR-186-3p–DAT–IGF1R axis as a therapeutic strategy in a Parkinson’s disease model

Huang,

Wan,

2024

J Transl Med

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With the increasing age of the population worldwide, the incidence rate of Parkinson’s disease (PD) is increasing annually. Currently, the treatment strategy for PD only improves clinical symptoms. No effective treatment strategy can slow down the progression of the disease. In the present study, whole transcriptome sequencing was used to obtain the mRNA and miRNA expression profiles in a PD mouse model, which revealed the pathogenesis of PD. The transcription factor RUNX3 upregulated the miR-186-3p expression in the PD model. Furthermore, the high miR-186-3p expression in PD can be targeted to inhibit the DAT expression, resulting in a decrease in the dopamine content of dopaminergic neurons. Moreover, miR-186-3p can be targeted to inhibit the IGF1R expression and prevent the activation of the IGF1R – P-PI3K – P-AKT pathway, thus increasing the apoptosis of dopaminergic neurons by regulating the cytochrome c – Bax – cleaved caspase-3 pathway. Our research showed that the RUNX3 – miR-186-3p – DAT – IGF1R axis plays a key role in the pathogenesis of PD, and miR-186-3p is a potential target for the treatment of PD. Supplementary Information The online version contains supplementary material available at 10.1186/s12967-024-05535-7.

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Chloride intracellular channel 4 participate in the protective effect of Ginkgolide B in MPP+ injured MN9D cells: insight from proteomic analysis

Cited by 3 publications

References 35 publications

The oxidoreductase CLIC4 is required to maintain mitochondrial function and resistance to exogenous oxidants in breast cancer cells

The oxidoreductase CLIC4 is required to maintain mitochondrial function and resistance to exogenous oxidants in breast cancer cells

Blending Technology Based on HPLC Fingerprint and Nonlinear Programming to Control the Quality of Ginkgo Leaves

Targeting the RUNX3–miR-186-3p–DAT–IGF1R axis as a therapeutic strategy in a Parkinson’s disease model

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