“…Although acetazolamide is rather a specific carbonic anhydrase inhibitor, it can affect sodium secretion indirectly, perhaps by changing the intracellular pH (Slegers & Moons, 1968). Furthermore, there have been suggestions (Parsons, 1956;Kinney & Code, 1964;Kitahara, & Imamura, 1966) that acetazolamide may inhibit chloride transport by mechanisms other than interference with carbonic anhydrase. Kitahara, Fox & Hogben (1967) have offered proof of this supposition by demonstrating that active chloride transport across frog cornea can be inhibited by acetazolamide, despite the complete absence of carbonic anhydrase in this tissue.…”