1994
DOI: 10.1016/0024-3205(94)00907-4
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Chlorinated dibenzo-p-dioxins and dibenzofurans and the human immune system 2. In vitro proliferation of lymphocytes from workers with quantified moderately-increased body burdens

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Cited by 12 publications
(7 citation statements)
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“…Although tests with whole blood are greatly superior to those with isolated cells, the latter were used for certain purposes (e.g., ex vivo studies) because higher cell numbers could be used, and less contamination occurred. 16,17 Evaluation after routine tetanus vaccination was either performed with a proliferation assay in the presence of tetanus toxoid, or by analyzing the tetanus antibody titers.…”
Section: Volunteers and Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Although tests with whole blood are greatly superior to those with isolated cells, the latter were used for certain purposes (e.g., ex vivo studies) because higher cell numbers could be used, and less contamination occurred. 16,17 Evaluation after routine tetanus vaccination was either performed with a proliferation assay in the presence of tetanus toxoid, or by analyzing the tetanus antibody titers.…”
Section: Volunteers and Methodsmentioning
confidence: 99%
“…Besides evaluating important components of the immune system, we have also measured the proliferative capacity of lymphocytes, 17 cultured ex vivo in the presence of mitogens (pokeweed mitogen [PWM], phytohemeagglutinin [PHA], concanavalin A [con A]), anti-human mAb against CD3 (anti-CD3), and tetanus toxoid. Since different lots of the mitogens often exhibit a varying potency for stimulation, standardization of the assays is essential if trials are performed over prolonged periods.…”
Section: Proliferative Capacity Of Lymphocytes Cultured With Stimulantsmentioning
confidence: 99%
“…Later investigations in the latter cohort did not corroborate these findings (21). In the Seveso and Times Beach cohorts and in decontamination workers proliferation of lymphocytes of exposed persons was undisturbed (16,18,25). A lowered ability of phagocytosis of the blood cells was reported among exposed Vietnamese subjects (19).…”
Section: Introduction 2378-tetrachlorodibenzo-p-dioxinmentioning
confidence: 77%
“…Neubert et al (3) did not find significant changes in the proliferation capacities of lymphocytes derived from persons with moderately increased body burdens of TCDD, whereas in a recent paper, Tonn et al. (4) report decreased responder cell function in allogeneically stimulated peripheral blood lymphocytes from industrial workers exposed 20 years before to considerable concentrations of TCDD.…”
Section: Introductionmentioning
confidence: 94%