Chlorinated pesticide concentration in semen of fertile and infertile men and correlation with sperm quality

Pant, Niraj; Kumar, Rakesh; Mathur, Neeraj; Srivastava, S. P.; Saxena, D. K.; Gujrati, V. R.

doi:10.1016/j.etap.2006.07.012

Cited by 48 publications

(35 citation statements)

References 20 publications

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“…There are several reports regarding the presence of some POPs, such as dioxins, dibenzofurans, and the dioxin-like PCBs, organochlorinated pesticides, in semen or seminal plasma (Kumar et al, 2000;Pant et al, 2007;Schecter et al, 1996;Younglai et al, 2002). In the present study, we found for the first time the presence of PBDEs in human semen and demonstrated that PBDEs could enter human semen like other POPs.…”

Section: Pbde Concentration In Human Semen Compared With In Human Bloodsupporting

confidence: 67%

Determination of polybrominated diphenyl ethers in human semen

Liu

Zhao

Zhu

et al. 2012

Environment International

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Some persistent organic pollutants (POPs) have been found in human semen but until this point it was unclear whether polybrominated diphenyl ethers (PBDEs) could be detected in human semen. In this study, PBDEs were found for the first time in human semen samples (n = 101) from Taizhou, China. The concentrations of total PBDEs (∑PBDEs) varied from 15.8 to 86.8 pg/g ww (median = 31.3 pg/g ww) and 53.2 to 121 pg/g ww (median = 72.3 pg/g ww) in semen and blood samples, respectively. The ∑PBDE level in semen was about two times lower than in human blood, which was different in the distribution in the two matrices from other POPs. A correlation of ∑PBDE concentration was found between paired semen and in blood. The results suggest that semen could be used to detect PBDE burden in human body as a non-invasive matrix. In addition, the levels of BDE-209 and BDE-153, especially the latter, were much higher in blood than in semen, while the levels of BDE-28, BDE-47 and BDE-99 were comparable in the two matrices, suggesting that low brominated congeners could be more easily transferred to semen than high brominated congeners. Considering different toxicities among the PBDE congeners, it might be more significant to measure PBDEs in semen than in blood for evaluating male reproduction risks of PBDEs.

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Section: Pbde Concentration In Human Semen Compared With In Human Bloodsupporting

confidence: 67%

Determination of polybrominated diphenyl ethers in human semen

Liu

Zhao

Zhu

et al. 2012

Environment International

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“…Studies performed in humans reported that exposure to pesticides may decrease spermatogenesis and male fertility (Roeleveld & Bretveld 2008). Furthermore, a significant association was found between organochlorine concentrations in the semen of male volunteers and sperm quality (Pant et al 2007).…”

Section: Introductionmentioning

confidence: 87%

Specific transgenerational imprinting effects of the endocrine disruptor methoxychlor on male gametes

2011

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Endocrine-disrupting chemicals (EDCs), among which methoxychlor (MXC), have been reported to affect the male reproductive system. This study evaluates the possible deleterious effects of MXC on imprinted genes. After administration of the chemical in adult male mice or in pregnant mice we analyzed by pyrosequencing possible methylation defects in two paternally imprinted (H19 and Meg3 (Gtl2)) and three maternally imprinted (Mest (Peg1), Snrpn, and Peg3) genes in the sperm and in the tail, liver, and skeletal muscle DNAs of the adult male mice and of the male offspring. MXC treatment of adult mice decreased the percentages of methylated CpGs of Meg3 and increased those of Mest, Snrpn, and Peg3 in the sperm DNA. MXC treatment of pregnant mice decreased the mean sperm concentrations by 30% and altered the methylation pattern of all the imprinted genes tested in the F1 offspring. In the latter case, MXC effects were transgenerational but disappeared gradually from F1 to F3. MXC did not affect imprinting in the somatic cells, suggesting that it exerts its damaging effects via the process of reprogramming that is unique to gamete development. A systematic analysis at the CpG level showed a heterogeneity in the CpG sensitivity to MXC. This observation suggests that not only DNA methylation but also other epigenetic modifications can explain the transgenerational effects of MXC. The reported effects of EDCs on human male spermatogenesis might be mediated by complex imprinting alterations analogous to those described in this study.

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“…Among the 15 studies reporting associations, three (3) studies found significant results for pyrethroid pesticides (Ji et al, 2011; Meeker et al, 2008; Xia et al, 2008). Relationships between the persistent organic pollutants (POPs) DDT and HCH and sperm characteristics were found in five studies (Aneck-Hahn et al, 2007; Haugen et al, 2011; Khan et al, 2010; Messaros et al, 2009; Pant et al, 2007). Organophosphates (OP) were shown to be associated with lowered sperm parameters in six of the studies (Hossain et al, 2010; Perez-Herrera et al, 2008; Perry et al, 2007, 2011; Recio-Vega et al, 2008; Yucra et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

“…Serum concentrations of p,p’ -DDE and p,p’- DDT were combined by Messaros et al (2009) to evaluate their associations with semen parameters: high sum p,p’ -DDE and p,p’ -DDT concentrations increased the odds of low sperm concentration, low sperm motility and abnormal morphology. In a study comparing 50 infertile men to 50 fertile men, p,p’ -DDE and p,p’ -DDD in seminal plasma were both associated with decreased sperm counts in infertile men (Pant et al, 2007). The evidence presented in these studies supports the hypothesis that exposure to DDT may be associated with decreased semen parameters, but future research should seek to strengthen the evidence for particular metabolites.…”

Section: Discussionmentioning

confidence: 99%

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

2013

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Of continuing concern are the associations between environmental or occupational exposures to pesticides and semen quality parameters. Prior research has indicated that there may be associations between exposure to pesticides of a variety of classes and decreased sperm health. The intent of this review was to summarize the most recent evidence related to pesticide exposures and commonly used semen quality parameters, including concentration, motility and morphology. The recent literature was searched for studies published between January, 2007 and August, 2012 that focused on environmental or occupational pesticide exposures. Included in the review are 17 studies, 15 of which reported significant associations between exposure to pesticides and semen quality indicators. Two studies also investigated the roles genetic polymorphisms may play in the strength or directions of these associations. Specific pesticides targeted for study included dichlorodiphenyltrichloroethane (DDT), hexachlorocyclohexane (HCH), and abamectin. Pyrethroids and organophosphates were analyzed as classes of pesticides rather than as individual compounds, primarily due to the limitations of exposure assessment techniques. Overall, a majority of the studies reported significant associations between pesticide exposure and sperm parameters. A decrease in sperm concentration was the most commonly reported finding among all of the pesticide classes investigated. Decreased motility was also associated with exposures to each of the pesticide classes, although these findings were less frequent across studies. An association between pesticide exposure and sperm morphology was less clear, with only two studies reporting an association. The evidence presented in this review continues to support the hypothesis that exposures to pesticides at environmentally or occupationally relevant levels may be associated with decreased sperm health. Future work in this area should focus on associations between specific pesticides or metabolic products and sperm quality parameters. Analysis of effects of varying genetic characteristics, especially in genes related to pesticide metabolism, also needs further attention.

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Chlorinated pesticide concentration in semen of fertile and infertile men and correlation with sperm quality

Cited by 48 publications

References 20 publications

Determination of polybrominated diphenyl ethers in human semen

Determination of polybrominated diphenyl ethers in human semen

Specific transgenerational imprinting effects of the endocrine disruptor methoxychlor on male gametes

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

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