Chloroacetic Acids

Koenig, Günter; Lohmar, Elmar; Rupprich, Norbert

doi:10.1002/14356007.a06_537

Cited by 7 publications

(7 citation statements)

References 52 publications

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“…Monochloroacetic acid (MCA) is used in the manufacturing of carboxymethyl cellulose (CMC) and pharmaceuticals [1,2] and is mainly produced via the chlorination of acetic acid [1]. An undesired feature of this production process is the chlorination of MCA to dichloroacetic acid (DCA).…”

Section: Introductionmentioning

confidence: 99%

Extractant screening for the separation of dichloroacetic acid from monochloroacetic acid by extractive distillation

Jongmans

Londoño

Mamilla

et al. 2012

Separation and Purification Technology

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Section: Introductionmentioning

confidence: 99%

Extractant screening for the separation of dichloroacetic acid from monochloroacetic acid by extractive distillation

Jongmans

Londoño

Mamilla

et al. 2012

Separation and Purification Technology

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“…Monochloroacetic acid (MCA) is widely produced through chlorination of acetic acid using acetic anhydride as a catalyst. The main drawback of this route is the production of dichloroacetic acid (DCA) as main by-product due to the chlorination of MCA [1]. These two components have to be separated to obtain the desired MCA.…”

Section: Introductionmentioning

confidence: 99%

Isobaric low pressure vapor–liquid equilibrium data for the binary system monochloroacetic acid+dichloroacetic acid

Londoño

Jongmans

Schuur³

et al. 2012

Fluid Phase Equilibria

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“…The activation of graphene oxide (GO) surfaces occurs by nucleophilic substitution reaction of the hydroxyl groups on the grapheme oxide with chloroacetic acid in the presence of NaOH to convert the –OH groups to a more reactive –COOH group (GO-CH 2 -COOH) [78,79,80]. Then, six arm amine-PEG is conjugated with GO-CH 2 -COOH through the activation of the carboxylic acid moiety with EDC and the formation of an amide bond.…”

Section: Synthesis Of Modified Bio-conjugated Peg Nanoparticles Acmentioning

confidence: 99%

Chemistry Routes for Copolymer Synthesis Containing PEG for Targeting, Imaging, and Drug Delivery Purposes

Rahme

Dagher

2019

Pharmaceutics

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Polyethylene glycol (PEG) is one of the most frequently used polymers for coating nanocarriers to enhance their biocompatibility, hydrophilicity, stability, and biodegradability. PEG is now considered to be among the best biocompatible polymers. It offers sterical hindrance against other nanoparticles and blood components such as opsonin, preventing their macrophage phagocytosis and resulting in a prolonged circulation time in blood stream, consequently a ‘stealth character’ in vivo. Therefore, PEG has a very promising future for the development of current therapeutics and biomedical applications. Moreover, the vast number of molecules that PEG can conjugate with might enhance its ability to have an optimistic perspective for the future. This review will present an update on the chemistry used in the modern conjugation methods for a variety of PEG conjugates, such methods include, but are not limited to, the synthesis of targeting PEG conjugates (i.e., Peptides, Folate, Biotin, Mannose etc.), imaging PEG conjugates (i.e., Coumarin, Near Infrared dyes etc.) and delivery PEG conjugates (i.e., doxorubicin, paclitaxel, and other hydrophobic low molecular weight drugs). Furthermore, the type of nanoparticles carrying those conjugates, along with their biomedical uses, will be briefly discussed.

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Chloroacetic Acids

Cited by 7 publications

References 52 publications

Extractant screening for the separation of dichloroacetic acid from monochloroacetic acid by extractive distillation

Extractant screening for the separation of dichloroacetic acid from monochloroacetic acid by extractive distillation

Isobaric low pressure vapor–liquid equilibrium data for the binary system monochloroacetic acid+dichloroacetic acid

Chemistry Routes for Copolymer Synthesis Containing PEG for Targeting, Imaging, and Drug Delivery Purposes

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