Chloroform fraction of Chaetomorpha brachygona, a marine green alga from Indian Sundarbans inducing autophagy in cervical cancer cells in vitro

Majumder, Indira; Paul, Subhabrata; Nag, Anish; Kundu, Rita

doi:10.1038/s41598-020-78592-9

Cited by 9 publications

(1 citation statement)

References 36 publications

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“…The complete detail of the binding cavities is represented in supporting information in Figures S4 and S5. Isatin derivatives were chosen as potential inhibitors for the COVID-19 NSP3 receptor (Majumder et al 2020 ). Further, Isatin is also present naturally in different body organs in different concentrations.…”

Section: Resultsmentioning

confidence: 99%

Insighting isatin derivatives as potential antiviral agents against NSP3 of COVID-19

et al. 2022

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The world is now facing intolerable damage in all sectors of life because of the deadly COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2. The discovery and development of anti-SARS-CoV-2 drugs have become pragmatic in the time needed to fight against this pandemic. The non-structural protein 3 is essential for the replication of transcriptase complex (RTC) and may be regarded as a possible target against SARS-CoV-2. Here, we have used a comprehensive in silico technique to find potent drug molecules against the NSP3 receptor of SARS-CoV-2. Virtual screening of 150 Isatin derivatives taken from PubChem was performed based on their binding affinity estimated by docking simulations, resulting in the selection of 46 ligands having binding energy greater than −7.1 kcal/mol. Moreover, the molecular interactions of the nine best-docked ligands having a binding energy of ≥ −8.5 kcal/mol were analyzed. The molecular interactions showed that the three ligands (S5, S16, and S42) were stabilized by forming hydrogen bonds and other significant interactions. Molecular dynamic simulations were performed to mimic an in vitro protein-like aqueous environment and to check the stability of the best three ligands and NSP3 complexes in an aqueous environment. The binding energy of the S5, S16, and S42 systems obtained from the molecular mechanics Poisson–Boltzmann surface area also favor the system's stability. The MD and MM/PBSA results explore that S5, S16, and S42 are more stable and can be considered more potent drug candidates against COVID-19 disease. Supplementary Information The online version contains supplementary material available at 10.1007/s11696-022-02298-7.

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Section: Resultsmentioning

confidence: 99%

Insighting isatin derivatives as potential antiviral agents against NSP3 of COVID-19

et al. 2022

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Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights

Chowdhury,

Bhuia,

Al Hasan

et al. 2024

Food Science & Nutrition

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Cancer is a collection of illnesses characterized by aberrant cellular proliferation that can infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well‐being due to its substantial morbidity and death rates worldwide. The potential of plant‐derived natural compounds as anticancer medicines has been assessed owing to their favorable attributes of few side effects and significant antitumor activity. Mangrove plants and their derived compounds have been scientifically shown to exhibit many significant beneficial biological activities, such as anti‐inflammatory, immunomodulatory, antioxidant, neuroprotective, cardioprotective, and hepatoprotective properties. This study summarized mangrove plants and their derived compounds as potential anticancer agents, with an emphasis on the underlying molecular mechanisms. To explore this, we gathered data on the preclinical (in vivo and in vitro) anticancer effects of mangrove plants and their derived compounds from reputable literature spanning 2000 to 2023. We conducted thorough searches in various academic databases, including PubMed, ScienceDirect, Wiley Online, SpringerLink, Google Scholar, Scopus, and the Web of Science. The results demonstrated that mangrove plants and their derived compounds have promising anticancer properties in preclinical pharmacological test systems through various molecular mechanisms, including induction of oxidative stress and mitochondrial dysfunction, cytotoxicity, genotoxicity, cell cycle arrest, apoptosis, autophagy, antiproliferative, antimetastatic, and other miscellaneous actions. Upon thorough observation of the pertinent information, it is suggested that mangrove plants and their derived chemicals may serve as a potential lead in the development of novel drugs for cancer therapy.

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Green and Blue Solutions: Natural Compounds from Plants and Marine Organisms Therapeutic Role in Induction of Cancer Cell Death

Chaudhry,

Zeenia,

Akim

et al. 2024

Interdisciplinary Cancer Research

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Chloroform fraction of Chaetomorpha brachygona, a marine green alga from Indian Sundarbans inducing autophagy in cervical cancer cells in vitro

Cited by 9 publications

References 36 publications

Insighting isatin derivatives as potential antiviral agents against NSP3 of COVID-19

Insighting isatin derivatives as potential antiviral agents against NSP3 of COVID-19

Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights

Green and Blue Solutions: Natural Compounds from Plants and Marine Organisms Therapeutic Role in Induction of Cancer Cell Death

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