Chlorogenic acid (CGA): A pharmacological review and call for further research

Naveed, Muhammad; Hejazi, Veghar; Abbas, Muhammad; Kamboh, Asghar Ali; Khan, Ghulam Jilany; Shumzaid, Muhammad; Ahmad, Fawwad; Babazadeh, Daryoush; FangFang, Xia; Modarresi-Ghazani, Faezeh; Li, Wenhua; Zhou, Xiaohui

doi:10.1016/j.biopha.2017.10.064

Cited by 1,135 publications

(700 citation statements)

References 67 publications

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“…From the analysis of the polyphenols, however, we could hypothesize that the inhibitory activity against the biofilm and the metabolism of bacterial biofilm cells was due not only to the presence of flavonoids, but also to the presence of phenolic acids, in particular chlorogenic and ferulic acids, whose capacity in this sense has been demonstrated by Virkam et al [39]. Moreover, phenolic acids, such as chlorogenic [40] and ferulic acids [41], are able to prevent and limit the formation of biofilms. In the case of cedar, there is a further consideration linked to the presence of rutin, which was reported for its inhibitory power on the biofilm formation of P. aeruginosa [42].…”

Section: Biofilm Formation and Metabolic Activity Of Biofilm Cellsmentioning

confidence: 95%

Polyphenols, Antioxidant, Antibacterial, and Biofilm Inhibitory Activities of Peel and Pulp of Citrus medica L., Citrus bergamia, and Citrus medica cv. Salò Cultivated in Southern Italy

et al. 2019

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The aim of this paper was to study the polyphenols of peel and pulp of three Citrus taxa-Citrus medica, Citrus bergamia, and Citrus medica cv. Salò-cultivated in the Cosenza province, Southern Italy, and to evaluate their antioxidant and antibacterial activity, performed against Escherichia coli, Listeria monocytogenes, Pseudomonas aeruginosa, Staphylococcus aureus, and Pectobacterium carotovorum. Furthermore, we assessed the inhibitory effect of the extracts on bacterial capacity to form biofilm, and on the metabolic activity of the cells present therein. The results indicated that such extracts could find new potential applications in the field of natural antioxidant and anti-bacterial agents in pharmaceutics, agriculture, and food fields.

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Section: Biofilm Formation and Metabolic Activity Of Biofilm Cellsmentioning

confidence: 95%

Polyphenols, Antioxidant, Antibacterial, and Biofilm Inhibitory Activities of Peel and Pulp of Citrus medica L., Citrus bergamia, and Citrus medica cv. Salò Cultivated in Southern Italy

et al. 2019

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“…Chlorogenic acid is a phenolic compound most widely occurring in plants and it has antioxidant and anti-inflammation activity known for his cardioprotective and antidiabetic effects. [34,35] Different studies reported that animal diets supplemented with coffee pulp, containing predominantly chlorogenic acid, reduced the oxidative stress in sheep [36] or improved the growth performance and decreased the diarrhea incidence of the weaned pigs, possibly by increasing the antioxidant capacity and enhancing the intestinal digestion and absorption function. [37] Several authors suggest that the regular consumption of fruit and vegetables (rich sources of polyphenols) reduces the risk of chronic human illnesses.…”

Section: Rp-hplc Analysis Of Phenolic Compoundsmentioning

confidence: 99%

Antioxidant Sources from Leaves of Russian Dandelion

Molinu

Piluzza

Campesi

et al. 2019

Chemistry & Biodiversity

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Taraxacum kok‐saghyz (TKS) is a dandelion species native to Kazakhstan, Uzbekistan and north‐west China, considered as a promising alternative source of natural rubber from its roots. The aim of this study was to investigate the possible exploitation of TKS leaves, a rubber byproduct, as a source of phenolic compounds with antioxidant properties for potential applications in forage, nutraceutical and pharmacological fields. Two accessions (TKS016, TKS018) grown under Mediterranean conditions of Sardinia were evaluated at vegetative and flowering stages. The leaves of TKS018 had the highest antioxidant capacity (19.6 mmol trolox equivalent antioxidant capacity 100 g−1), total phenolic (106.4 g gallic acid equivalent kg−1), tannic phenolics (58.5 g gallic acid equivalent kg−1) and total flavonoid contents (22.9 g catechin equivalent kg−1). At both phenological stages, TKS016 showed significantly lower values than TKS018 in 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), total phenolic and tannic phenolics. Six individual molecules were identified, namely chlorogenic, cryptochlorogenic, caffeic, sinapic, chicoric and 3,4‐dimethoxycinnamic acids. Chicoric (8.53–10.68 g kg−1 DW) and chlorogenic acids (4.18–7.04 g kg−1 DW) were the most abundant. TKS leaves represent a valuable source of chicoric acid with potential application as antioxidant to be used as herbal medicine and nutrition for production of healthy food/feed.

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“…The majority of the PPS, chlorogenic acids, is a polyphenol family of esters, including hydroxycinnamic acids with quinic acid (Buitimea-Cantua, Gutierrez-Uribe, & Serna-Saldivar, 2018;Naveed et al, 2018;Velickovic & Stanic-Vucinic, 2018), which possesses excellent hydrophilic antioxidant activity and other therapeutic properties. In general, phenolic compounds are crucial for plant growth and defensing against infection and injury, providing an important impact on oxidative stability (Arriola et al, 2019;Pacifico et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Polyphenols from Stevia rebaudiana (Bertoni) leaves and their functional properties

Myint

Xia

et al. 2020

Journal of Food Science

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The major polyphenol components from Stevia rebaudiana (Bertoni) leaves (PPS) are chlorogenic acids, a polyphenol family of esters, including hydroxycinnamic acids with quinic acid, which possesses excellent hydrophilic antioxidant activity and other therapeutic properties. As an abundant byproduct during production of steviol glycosides, the PPS would be a new antioxidantive food resource or additives applied in foods and drugs with antidiabetic function. Extracting PPS from S. rebaudiana (Bertoni) leaves together with steviol glycosides would be an economic process, which will change most operation process in current Stevia factories. The quantification of PPS needs to be unified for regulation. In view of the current regulation status of polyphenols and extracts from Stevia, the PPS would be ready to go to the market with few regulation barriers in the near future. This review will summarize the analysis, extraction, and some functional properties of PPS, such as antioxidant, antidiabetic, antimicrobial, anti-inflammatory, and anticancer.

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Chlorogenic acid (CGA): A pharmacological review and call for further research

Cited by 1,135 publications

References 67 publications

Polyphenols, Antioxidant, Antibacterial, and Biofilm Inhibitory Activities of Peel and Pulp of Citrus medica L., Citrus bergamia, and Citrus medica cv. Salò Cultivated in Southern Italy

Polyphenols, Antioxidant, Antibacterial, and Biofilm Inhibitory Activities of Peel and Pulp of Citrus medica L., Citrus bergamia, and Citrus medica cv. Salò Cultivated in Southern Italy

Antioxidant Sources from Leaves of Russian Dandelion

Polyphenols from Stevia rebaudiana (Bertoni) leaves and their functional properties

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