Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice

Cho, Ae-Sim; Jeon, Seon-Min; Kim, Myung‐Joo; Yeo, Jiyoung; Seo, Kwon‐Il; Choi, Myung‐Sook; Lee, Mi-Kyung

doi:10.1016/j.fct.2010.01.003

Cited by 694 publications

(471 citation statements)

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“…In previous works, rutin has been shown to enhance adiponectin secretion [36], on the other hand, chlorogenic acid to improve adiponectin levels with body weight, lipid metabolism, and obesity-related hormones in mice [14]. Since ingredients identified in PJT extracts excluding rutin and chlorogenic acid have not been shown to exhibit adiponectin secretion property yet, we have selected rutin and chlorogenic acid as the candidates of phytochemicals in PJT extracts.…”

Section: Discussionmentioning

confidence: 99%

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Peucedanum japonicum Thunb (PJT) Extracts Enhance Adiponectin Secretion in Human Metabolic Stem Cells Screening System and in Healthy Individuals

Koga¹,

Sakaue²,

Matsumoto³

et al. 2015

Biochem Physiol

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Adiponectin is an adipocyte specific-secreted protein playing a major role in regulating insulin sensitivity and lipid metabolism. Peucedanum japonicum Thunb (PJT) grown on the cliff of Tokunoshima Island in Japan contains rich polyphenolic compounds and exerts hypolipidemic properties. In this study we studied the efficacy of PJT on the adiponectin secretion in the adipocytes differentiated from human Metabolic Stem Cells (MSC) and in healthy individuals. Three types of PJT extracts of each (water, 50% ethanol, 100% ethanol extracts), rutin, or chlorogenic acid as phytochemical candidates of the PJT extracts was dropped directly onto the differentiated adipocytes from MSC of obese patients at day 8 and adiponectin levels in the culture medium were measured at day 10 and 12. The efficacy of PJT on adiponectin secretion (1260 mg/day for 3 months) was examined for 46 healthy individuals in an open labeledpreliminary study. Chlorogenic acid and rutin showed that they had more positive effects on adiponectin secretion than PJT extracts. In the study of healthy individuals, serum adiponectin levels of the elder individuals significantly increased after the trial. PJT extracts might have an adiponectin secretion-enhancing properties, attributing partly to rutin and chlorogenic acid.

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Section: Discussionmentioning

confidence: 99%

“…Islands comprising Tokuno-shima Island of Japan contains rich phenolic compounds and has been used as a folk medicine traditionally [10][11][12][13][14]. Recently the hypolipidemic efficacy of PJT has been indicated using mice model with high-fat diet in some studies [15,16].…”

Section: Peucedanum Japonicum Thunb (Pjt) Grown On the Cliff Of Okinawamentioning

confidence: 99%

Peucedanum japonicum Thunb (PJT) Extracts Enhance Adiponectin Secretion in Human Metabolic Stem Cells Screening System and in Healthy Individuals

Koga¹,

Sakaue²,

Matsumoto³

et al. 2015

Biochem Physiol

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“…Senyawa aktif kopi memiliki efek sebagai anti-hiperglikemia, anti-oksidan, peningkatan sensitivitas insulin (Downey, 2013) dan mencegah terjadinya penyimpanan lipid dan karbohidrat (Shimoda, Seki, & Aitani, 2006). Ekstrak kopi hijau berpotensi menurunkan akumulasi lipid (Cho et al, 2010) dan glukosa dalam tubuh melalui beberapa mekanisme (Li et al, 2009). Salah satu senyawa aktif kopi hijau, asam klorogenat, mampu meningkatkan metabolisme tubuh (Murase et al, 2011), meningkatkan oksidasi asam lemak (Li et al, 2009;Cho et al, 2010), menurunkan kadar trigliserid di hepar (Shimoda, Seki, & Aitani, 2006), dan menginhibisi kerja enzim amilase (Narita & Inouye, 2009) & lipase pankreas pada intestinal (Ong, Hsu, & Tan, 2012).…”

Section: Pendahuluanunclassified

“…Ekstrak kopi hijau berpotensi menurunkan akumulasi lipid (Cho et al, 2010) dan glukosa dalam tubuh melalui beberapa mekanisme (Li et al, 2009). Salah satu senyawa aktif kopi hijau, asam klorogenat, mampu meningkatkan metabolisme tubuh (Murase et al, 2011), meningkatkan oksidasi asam lemak (Li et al, 2009;Cho et al, 2010), menurunkan kadar trigliserid di hepar (Shimoda, Seki, & Aitani, 2006), dan menginhibisi kerja enzim amilase (Narita & Inouye, 2009) & lipase pankreas pada intestinal (Ong, Hsu, & Tan, 2012). Selain asam klorogenat, kandungan polifenol pada kopi juga berpotensi menurunkan akumulasi lemak viseral (Nagao et al, 2009).…”

Section: Pendahuluanunclassified

The Effect of Orlistat, Green Coffee Bean Extract, and Its Combinations on Lipid Profi le and Adiponectin Levels

Setyono¹,

Nugroho²,

Mustofa³

et al. 2017

J. Ners

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ABSTRAKPendahuluan: Prevalensi obesitas diperkirakan meningkat mencapai 19,1% dari penduduk usia 15 tahun ke atas. Penelitian ini bertujuan untuk mengetahui perbedaan efek anti-obesitas orlistat, ekstrak biji kopi hijau (Coffea canephora robusta), dan kombinasinya terhadap kadar adiponektin dan profi l lipid. Metode: Penelitian ini merupakan penelitian true experimental post test only with control group design dengan rancangan acak lengkap (RAL). Hewan coba dikelompokkan menjadi 6 kelompok, yaitu 1(kontrol negatif), kelompok 2 (kontrol positif), kelompok 3 (kelompok tikus obesitas yang diberi Orlistat dosis 15,9 mg/kgBB),kelompok 4 (kelompok tikus obesitas yang diberi ekstrak etanol biji kopi hijau dosis 400 mg/kgBB), kelompok 5 (kelompok tikus obesitas yang diberi ekstrak air biji kopi hijau dosis 400 mg/kgBB), dan kelompok 6 (kelompok tikus obesitas yang diberi kombinasi Orlistat dosis 15,9 mg/kgBB dan ekstrak etanol biji kopi hijau dengan dosis 400 mg/kgBB). Profi l lipid dan kadar adiponektin diukur dengan spektrofotometer pada serapan 500nm. Data yang diperoleh diuji dengan one-way ANOVA dilanjutkan dengan analisis Post Hoc Least Signifi cant Difference (LSD) dengan α=0,05. Hasil: Pemberian ekstrak etanol kopi hijau lebih efi sien dalam menurunkan kadar LDL, meningkatkan HDL, dan menurunkan kadar kolesterol total secara signifi kan pada tikus putih yang diinduksi diet HFD, namun tidak ada perbedaan dalam menurunkan trigliserid. Kombinasi ekstrak etanol kopi hijau dengan Orlistat menunjukkan efek peningkatan kadar adiponektin yang paling tinggi dibandingkan dengan kelompok perlakuan lain. Diskusi: Ekstrak etanol kopi hijau mudah berdifusi melalui epitel saluran pencernaan. Kopi hijau mengandung senyawa aktif asam klorogenat yang mampu meningkatkan metabolisme tubuh, meningkatkan oksidasi asam lemak, menurunkan kadar trigliserid di hepar, dan menginhibisi kerja enzim amilase dan lipase pankreas pada intestinal. Selain asam klorogenat, kandungan polifenol pada kopi juga berpotensi menurunkan akumulasi lemak viseral. Sediaan ekstrak dengan pelarut etanol memungkinkan proses absorpsi dilakukan secara efi sien dan cepat sehingga efek yang ditimbulkan lebih optimal.Kata Kunci: obesitas, orlistat, kopi hijau, profi l lipid, adiponektin ABSTRACT Introduction: Obesity prevalence is estimated increases, reached 19.1% of the population aged 15 years and over. This study aimed to determine the differences of the anti-obesity effect of orlistat, an extract of green coffee beans (Coffea canephora robusta), and its combination to the adiponectin levels and lipid profi le. Method: This research was true experimental post -test only with control group design with completely randomized design (CRD). Experimental animals (Rattus novergicus) were divided into

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“…[38][39][40] The active ingredients of C-MED-100® and Activar AC-11® have been attributed to QA, and QA carboxy alkyl esters, such as CGA. 1 Most recent studies have shown that CGA and QA have anti-hepatitis B virus activity, 41 anti-obesity property, 42 radio-protective effects 43 and beneficial effects on cardiovascular diseases via suppressing P-selectin expression on platelets. 44 In particular, such extracts have been found to have various anti-inflammatory effects such as inhibition of the production of the inflammatory cytokine TNF, scavenges free radicals 45 and the activation of the central transcription factor nuclear factor κB (NF-κB).…”

Section: Biological Activities Of Qa and Its Derivativesmentioning

confidence: 99%

Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents

Zeng¹

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Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice

Cited by 694 publications

References 40 publications

Peucedanum japonicum Thunb (PJT) Extracts Enhance Adiponectin Secretion in Human Metabolic Stem Cells Screening System and in Healthy Individuals

Peucedanum japonicum Thunb (PJT) Extracts Enhance Adiponectin Secretion in Human Metabolic Stem Cells Screening System and in Healthy Individuals

The Effect of Orlistat, Green Coffee Bean Extract, and Its Combinations on Lipid Profi le and Adiponectin Levels

Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents

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