Chlorogenic acid, rutin, and quercetin from Lysimachia christinae alleviate triptolide-induced multi-organ injury in vivo by modulating immunity and AKT/mTOR signal pathway to inhibit ferroptosis and apoptosis

Wu, Xiaohui; Wang, Junming; Li, Bingyin; Gong, Mingzhu; Cao, Chao; Song, Lianchun; Qin, Lingyu; Wang, Yanmei; Zhang, Yueyue; Li, Yamin

doi:10.1016/j.taap.2023.116479

Cited by 18 publications

(10 citation statements)

References 65 publications

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“…NAC are generally less toxic, but this does not guarantee they are all safe. Recent studies have confirmed that triptolide [ 242 ], toosendanin [ 243 ], aurantio-obtusin [ 244 ], and Epimedium koreanum Nakai [ 245 ] all induced hepatotoxicity by triggering ferroptosis. NAC that triggers ferroptosis in HSCs and HCC cells may also cause damage to healthy hepatocytes.…”

Section: Discussion and Prospectsmentioning

confidence: 99%

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Wu,

Zhu,

Liu

et al. 2024

Antioxidants

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Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation of ferrous ions (Fe2+) and lipid peroxides. As the metabolic hub of the body, the liver is crucial for iron storage and lipid metabolism. The liver seems to be closely related to ferroptosis through iron and lipid metabolism. Liver disease greatly threatens host health, and exploring effective interventions is essential. Mounting studies have demonstrated that ferroptosis is one of the possible pathogenic mechanisms involved in liver disease. Targeting ferroptosis may provide a promising opportunity for treating liver disease. However, drugs targeting ferroptosis are extremely limited. Therefore, it is an urgent need to develop new and safe ferroptosis regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, have recently shown great therapeutic potential in liver disease via modulating ferroptosis-related genes or pathways. Here, we outline the molecular mechanism of ferroptosis and systematically summarize the regulatory function of NAC on ferroptosis in liver disease. Finally, we discuss the application prospects and potential problems concerning NAC as ferroptosis regulators for managing liver disease.

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Section: Discussion and Prospectsmentioning

confidence: 99%

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Wu,

Zhu,

Liu

et al. 2024

Antioxidants

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show abstract

“…Furthermore, an increase in serum unsaturated iron binding capacity and decrease in liver and serum iron levels was observed ( 75 ). Due to rutin’s ability to chelate iron, it may be able to prevent NAFLD and be useful in treating disorders where iron buildup occurs ( 76 ). However, further research is needed to determine the precise structural and pharmacodynamic mechanism of rutin’s therapeutic effects.…”

Section: Tcm and Monomers Regulates Ferroptosis To Inhibit Nonalcohol...mentioning

confidence: 99%

Mechanisms of ferroptosis in nonalcoholic fatty liver disease and therapeutic effects of traditional Chinese medicine: a review

Wang,

Que,

Luo

et al. 2024

Front. Med.

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Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of fat in hepatocytes (nonalcoholic fatty liver (NAFL)), and lobular inflammation and hepatocyte damage (which characterize nonalcoholic steatohepatitis (NASH) are found in most patients). A subset of patients will gradually develop liver fibrosis, cirrhosis, and eventually hepatocellular carcinoma, which is a deadly disease that threatens human life worldwide. Ferroptosis, a novel nonapoptotic form of programmed cell death (PCD) characterized by iron-dependent accumulation of reactive oxygen radicals and lipid peroxides, is closely related to NAFLD. Traditional Chinese medicine (TCM) has unique advantages in the prevention and treatment of NAFLD due to its multicomponent, multipathway and multitarget characteristics. In this review, we discuss the effect of TCM on NAFLD by regulating ferroptosis, in order to provide reference for the further development and application of therapeutic drugs to treat NAFLD.

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“… Myocardial fibrosis; Apoptosis. [ [159] , [160] , [161] ] Alkaloid Tetramethylpyrazine Ligusticum chuanxiong microRNA-499a, Sirtuin1; PI3K/Akt pathway. Oxidative stress; Apoptosis.…”

Section: The Representative Natural Products With Anti-heart Failure ...mentioning

confidence: 99%

The recent advance and prospect of natural source compounds for the treatment of heart failure

Chen,

Liu,

et al. 2024

Heliyon

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Chlorogenic acid, rutin, and quercetin from Lysimachia christinae alleviate triptolide-induced multi-organ injury in vivo by modulating immunity and AKT/mTOR signal pathway to inhibit ferroptosis and apoptosis

Cited by 18 publications

References 65 publications

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Mechanisms of ferroptosis in nonalcoholic fatty liver disease and therapeutic effects of traditional Chinese medicine: a review

The recent advance and prospect of natural source compounds for the treatment of heart failure

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