Chlorogenic acids: A pharmacological systematic review on their hepatoprotective effects

Xue, Haoyu; Wei, Mengjuan; Ji, Lili

doi:10.1016/j.phymed.2023.154961

Cited by 15 publications

(6 citation statements)

References 109 publications

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“…CGAs can facilitate the maintenance of metabolic homeostasis of glucose and lipids [38]. One mechanism involves the modulation of activities of AMP-activated protein kinase (AMPK) and ERK1/2 [4] (Figure 2C,D). AMPK is a master energy sensor that regulates cellular glucose and lipid metabolism.…”

Section: Glucose and Lipid Metabolic Homeostasis Modulation (Figure 1b)mentioning

confidence: 99%

“…CGA can mediate hepatoprotective roles in various pathological conditions of the liver via antioxidant and anti-inflammatory features [4]. (1) It can inhibit TLR4-mediated activation of NF-κB, thus suppressing pro-inflammatory responses; (2) it can activate the AMPK pathway to modulate metabolic homeostasis; (3) it can increase the activity of the Nrf2 pathway, thus exerting antioxidant effects; and (4) it can inhibit caspases' activation to suppress hepatic apoptosis induced by chemicals or toxins.…”

Section: Hepatoprotectionmentioning

confidence: 99%

“…Chlorogenic acid (CGA) family members are abundant dietary phenolic acid compounds in plants, conjugating the hydroxy group of quinic acid and the carboxyl group of caffeic acid as the parent structure. CGA family includes (1) 1L-(−)-quinic acid, (2) caffeic acid (CA), (3) ferulic acid, and (4) the p-coumaric acid (p-CoQA) group including p-CoQAs, caffeoylquinic acids (CQAs), and feruloylquinic acids (FQAs) [1][2][3][4]. The CGA family has shown multiple protective effects on mitigating many chronic inflammatory and age-related disorders through exerting the central actions of anti-inflammation, antioxidation, and metabolic homeostasis modulation [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

Nguyen,

Taine,

Meng

et al. 2024

Nutrients

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Chlorogenic acid (CGA) is a type of polyphenol compound found in rich concentrations in many plants such as green coffee beans. As an active natural substance, CGA exerts diverse therapeutic effects in response to a variety of pathological challenges, particularly conditions associated with chronic metabolic diseases and age-related disorders. It shows multidimensional functions, including neuroprotection for neurodegenerative disorders and diabetic peripheral neuropathy, anti-inflammation, anti-oxidation, anti-pathogens, mitigation of cardiovascular disorders, skin diseases, diabetes mellitus, liver and kidney injuries, and anti-tumor activities. Mechanistically, its integrative functions act through the modulation of anti-inflammation/oxidation and metabolic homeostasis. It can thwart inflammatory constituents at multiple levels such as curtailing NF-kB pathways to neutralize primitive inflammatory factors, hindering inflammatory propagation, and alleviating inflammation-related tissue injury. It concurrently raises pivotal antioxidants by activating the Nrf2 pathway, thus scavenging excessive cellular free radicals. It elevates AMPK pathways for the maintenance and restoration of metabolic homeostasis of glucose and lipids. Additionally, CGA shows functions of neuromodulation by targeting neuroreceptors and ion channels. In this review, we systematically recapitulate CGA’s pharmacological activities, medicinal properties, and mechanistic actions as a potential therapeutic agent. Further studies for defining its specific targeting molecules, improving its bioavailability, and validating its clinical efficacy are required to corroborate the therapeutic effects of CGA.

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Section: Glucose and Lipid Metabolic Homeostasis Modulation (Figure 1b)mentioning

confidence: 99%

Section: Hepatoprotectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

Nguyen,

Taine,

Meng

et al. 2024

Nutrients

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“…Ginsenosides can be extracted from many species of Panax , and these compounds have antioxidant, neuroprotective, and learning- and memory-enhancing properties in humans [ 14 , 15 ]. Chlorogenic acids (CGAs) are a class of naturally occurring polyphenols, widely found in medicinal plants such as Eucommia ulmodies , Lonicera japonica , and tea, which are known for their hepatoprotective effects [ 16 , 17 ]. Therefore, the metabolomic analysis of related plants is an effective way to reveal their medicinal components.…”

Section: Introductionmentioning

confidence: 99%

Revealing Medicinal Constituents of Bistorta vivipara Based on Non-Targeted Metabolomics and 16S rDNA Gene Sequencing Technology

He,

Tang,

Cao

et al. 2024

Molecules

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Bistorta vivipara is a medicinal plant with a long history, but there are few studies on the effects of its medicinal components and endophytic bacteria on the accumulation of secondary metabolites. Therefore, in this study, non-targeted metabolomics techniques and 16s rDNA techniques were used to study B. vivipara from different regions. A total of 1290 metabolites and 437 differential metabolites were identified from all samples. Among them, flavonoids, isoflavonoids, and benzopyrans are the main medicinal components of B. vivipara; these have potential anticancer, antiviral, and antioxidant properties, as well as potential applications for the treatment of atrial fibrillation. In addition, irigenin, an important medicinal component, was identified for the first time. The endophytic bacterial communities in the root tissues of B. vivipara from different regions were also different in composition and richness. Hierarchical clustering heat map analysis showed that Proteobacteria and Actinobacteriota bacteria significantly affected the accumulation of many medicinal components in the roots of B. vivipara.

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“…The amount of vitamin E and C obtained from food has an inverse relationship with how severe NAFLD is (14). Natural polyphenols found in large quantities in tea and coffee, termed chlorogenic acids, have also demonstrated to have significant anti-inflammatory and antioxidant qualities against a variety of liver conditions, including MAFLD (15).…”

Section: Introductionmentioning

confidence: 99%

Dietary inflammatory index is associated with metabolic dysfunction-associated fatty liver disease among United States adults

Yan,

Zhou,

Ding

et al. 2024

Front. Nutr.

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BackgroundMetabolic dysfunction-associated fatty liver disease (MAFLD) is presently the most prevalent chronic liver disorder globally that is closely linked to obesity, dyslipidemia metabolic syndrome, and type 2 diabetes mellitus (T2DM). Its pathogenesis is strongly associated with inflammation, and diet is a major factor in reducing inflammation. However, current research has focused primarily on exploring the relationship between diet and NAFLD, with less research on its link to MAFLD.MethodsIn this research, using dietary inflammatory index (DII) as a measure to assess dietary quality, we analyzed the relationship between diet and MAFLD. Data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018, including 3,633 adults with complete DII and MAFLD, were used to develop cross-sectional analyses. Logistic regression analysis was adapted for investigating the relationship between DII and MAFLD development. Additionally, subgroup analysis and threshold effect analysis were carried out.ResultsA positive link between DII and MAFLD was found in the fully adjusted model (OR = 1.05; 95%CI, 1.00–1.11, p < 0.05). Subgroup analysis indicated that there was no significant dependence for the connection between DII and MAFLD except for the subgroup stratified by age. Compared with other age groups, people with MAFLD had 20% higher DII scores than non-MAFLD participants in those aged 20–41 years old (OR = 1.20; 95%CI, 1.08–1.33, p < 0.001). Furthermore, we found a U-shaped curve with an inflection point of 3.06 illustrating the non-linear connection between DII and MAFLD.ConclusionAs a result, our research indicates that pro-inflammatory diet may increase the chance of MAFLD development, thus improved dietary patterns as a lifestyle intervention is an important strategy to decrease the incidence of MAFLD.

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Chlorogenic acids: A pharmacological systematic review on their hepatoprotective effects

Cited by 15 publications

References 109 publications

Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

Revealing Medicinal Constituents of Bistorta vivipara Based on Non-Targeted Metabolomics and 16S rDNA Gene Sequencing Technology

Dietary inflammatory index is associated with metabolic dysfunction-associated fatty liver disease among United States adults

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