Chlorophyll Sensitizers in Photodynamic Therapy

Brandis, Alexander; Salomon, Yoram; Scherz, Avigdor

doi:10.1007/1-4020-4516-6_32

Cited by 48 publications

(38 citation statements)

References 158 publications

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“…They have a low cost production, lack of mutagenic activity, high efficiency and high level of safety to humans and, in general, to other mammalian species [22,128].…”

Section: Insect Pest Eliminationmentioning

confidence: 99%

Potential applications of porphyrins in photodynamic inactivation beyond the medical scope

Alves

Faustino

Neves

et al. 2015

Journal of Photochemistry and Photobiology C: Photochemistry Re

198

128

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a b s t r a c tAlthough the discovery of light-activated antimicrobial agents had been reported in the 1900s, only more recently research work has been developed toward the use of photodynamic process as an alternative to more conventional methods of inactivation of micro(organisms). The photoprocess causes cell death through irreversible oxidative damage by reactive oxygen species produced by the interaction between a photosensitizing compound and a light source.With great emphasis on the environmental area, photodynamic inactivation (PDI) has been tested in insect eradication and in water disinfection. Lately, other studies have been carried out concerning its possible use in aquaculture waters or to the control of food-borne pathogens. Other potential applications of PDI in household, industrial and hospital settings have been considered.In the last decade, scientific research in this area has gained importance not only due to great developments in the field of materials chemistry but also because of the serious problem of the increasing number of bacterial species resistant to common antibiotics. In fact, the design of antimicrobial surfaces or selfcleaning materials is a very appealing idea from the economic, social and public health standpoints. Thus, PDI of micro(organisms) represents a promising alternative.In this review, the efforts made in the last decade in the investigation of PDI of (micro)organisms with potential applications beyond the medical field will be discussed, focusing on porphyrins, free or immobilized on solid supports, as photosensitizing agents.

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“…They have a low cost production, lack of mutagenic activity, high efficiency and high level of safety to humans and, in general, to other mammalian species [22,128].…”

Section: Insect Pest Eliminationmentioning

confidence: 99%

Potential applications of porphyrins in photodynamic inactivation beyond the medical scope

Alves

Faustino

Neves

et al. 2015

Journal of Photochemistry and Photobiology C: Photochemistry Re

198

128

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“…One photosensitizer is chlorophyll which can be obtained from leaf extract [7]. Chlorophyll from Pterocarpus indicus was made as an antimicrobial drug [11].…”

Section: Resultsmentioning

confidence: 99%

“…Chlorophyll is a pigment from green plants which is activated by light energy [7]. One such green plant is angsana (Pterocarpus indicus).…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Inactivation for Phatogenic Bacteria: Adding Chlorophyll and Oxygen

Hidayatulail¹,

Yasin²,

Astuti³

2018

Proceedings of the 1st International Conference Postgraduate School Universitas Airlangga : "Implementation of Climate Change A

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Abstract-Photodynamic inactivation has been developed in reducing colony bacteria such as Staphylococcus aureus. Chlorophyll is known as a green pigment which can act as a photosensitizer. This research aimed to reduce colony using blue laser diode, chlorophyll and oxygen. Chlorophyll was produced from leaf extract of angsana (Pterocarpus indicus) and oxygen source obtained by medical oxygen. The treatments were divided to four groups, i.e. laser group, laser and adding chlorophyll group, laser and adding oxygen and laser and adding chlorophyll and oxygen. This result showed that 17.96% decrease at laser and adding chlorophyll group with time exposure of 40s.

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“…Эти вещества при воздействии ви-димого света определенной длины вол-ны и соответствующей мощности гене-рируют активные формы кислорода, что позволяет эффективно инактивировать атипичные клетки и микроорганизмы путем запуска каскада фотохимических реакций [8,9,11,12,15]. К настояще-му времени в клинической практике используется ряд ФС для диагностики и лечения онкологических заболева-ний, гнойно-воспалительных заболева-ний ЛОР-органов, обработки ран и т.д.…”

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“…К настояще-му времени в клинической практике используется ряд ФС для диагностики и лечения онкологических заболева-ний, гнойно-воспалительных заболева-ний ЛОР-органов, обработки ран и т.д. [8,9,11,12,15]. В отличие от антибио-тиков противомикробное действие ФДТ не снижается со временем, а у патоге-нов не развивается устойчивости к ней [11,15].…”

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Chlorin Photosensitisers for Antimicrobial Photodynamic Therapy

Кустов¹,

Garasko²,

Белых³

et al. 2016

УСЕ (ACNR)

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Проведено исследование антимикробной активности шести фотосенсибилизаторов (ФС) хлоринового ряда в отношении фирмикутных бактерий Staphylococcus aureus, грациликутных бактерий Escherichia coli и грибов Candida albicans. Показано, что использование ФС, адсорбированных на твердых поверхностях, в случае плотных питательных сред в целом малоэффективно. Катионные ФС, в зависимости от величины заряда и положения заряженной группы в молекуле, при испытании в жидких питательных средах и невысо-ких концентрациях ФС (0,00005 моль/кг) обнаруживают высокую токсичность в отношении Staphylococcus aureus и Candida albicans, однако, практически не проявляют антимикробной активности в отношении грам-отрицательных микроорганизмов. Напротив, гидрофобное производное хлорина е 6 с фрагментом 2,3-дигидроксиметил-1,4-хиноксалина обладает достаточно высокой световой токсичностью в отношении всех трех видов микроорганизмов, что позволяет на данном этапе считать его перспективным для проведе-ния антибактериальной фотодинамической терапии (ФДТ). The investigation of antimicrobial activity of six chlorin photosensitizers (PS) in relation to of fi rmicutes Staphylococcus aureus, gracilicutes Escherichia coli and fungi Candida albicans was performed. The using of PS which are adsorbed on solid surfaces are ineffective in the case of dense nutrient medium. According to the charge and the position of charged groups in the molecule, the cationic PS in liquid media at low PS concentrations (0.00005 mol/kg) were tested. Their high toxicity against Staphylococcus aureus and Candida albicans and the absense of antimicrobial activity in relation to gram-negative microorganisms were shown. In contrast, the hydrophobic chlorin e 6 derivative with a fragment of 2,3-dihydroxymethyl-1,4-quinoxaline has a suffi ciently high light toxicity against all three types of microorganisms, which allows to consider it as a promising antimicrobial drug for photodynamic therapy (PDT).

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Chlorophyll Sensitizers in Photodynamic Therapy

Cited by 48 publications

References 158 publications

Potential applications of porphyrins in photodynamic inactivation beyond the medical scope

Potential applications of porphyrins in photodynamic inactivation beyond the medical scope

Photodynamic Inactivation for Phatogenic Bacteria: Adding Chlorophyll and Oxygen

Chlorin Photosensitisers for Antimicrobial Photodynamic Therapy

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