Chloroprocaine Antagonism of Epidural Opioid Analgesia

Camann, William; Hartigan, Philip M.; Gilbertson, Lesley; Johnson, Mark D.; Datta, Sanjay

doi:10.1097/00000542-199011000-00011

Cited by 38 publications

(10 citation statements)

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“…21 The mechanism of this interaction is unclear, but appears to involve one subset of spinal opioid receptors, as it does not occur when chloroprocaine is combined with kappa-agonist opioids. 20 While our previous study supported a positive interaction between fentanyl and procaine in intensifying block and reducing the failure rate, the current data suggest that there is another undefined interaction that adversely impacts the frequency and severity of pruritus.…”

Section: Discussioncontrasting

confidence: 50%

Intrathecal fentanyl-induced pruritus is more severe in combination with procaine than with lidocaine or bupivacaine

Mulroy

Larkin

Siddiqui

2001

Regional Anesthesia and Pain Medicine

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Section: Discussioncontrasting

confidence: 50%

Intrathecal fentanyl-induced pruritus is more severe in combination with procaine than with lidocaine or bupivacaine

Mulroy

Larkin

Siddiqui

2001

Regional Anesthesia and Pain Medicine

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“…A recent study by our own group attempted to examine this drug interaction further. 9 We suggested that 2-CP may be a pure mu-receptor antagonist, inasmuch as epidural butorphanol (a kappareceptor agonist) showed a similar analgesic profile after either lidocaine or 2-CP anaesthesia. However, that study did not assess the possible contribution of supraspinal (i.e., systemic) effects of the epidural butorphanol.…”

Section: Discussionmentioning

confidence: 89%

Epidural nalbuphine for analgesia following caesarean delivery: dose-response and effect of local anaesthetic choice

et al. 1991

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“…Epidurally administered nalbuphine reported satisfactory outcome with regard to quality of analgesia and incidence of serious complications 13,14,15 . In the present study also there was no respiratory depression and nausea and vomiting; however, PaCO2 level were not monitored.…”

Section: Discussionmentioning

confidence: 93%

A Comparative Study of Epidural Nalbuphine With Bupivacaine vs. Bupivacaine Alone in Infraumbilical Surgeries

Ramakrishnan¹,

Shunmugavelu²

2016

jemds

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BACKGROUNDAnalgesia, one of the components of triad of anaesthesia, has now extended to relief of postoperative pain, chronic pain and cancer pain. The spinal route of analgesia plays an important role in the intra and postoperative period. Effective postoperative analgesia reduces postoperative morbidity, allows early ambulation and discharge. MATERIALS AND METHODSThis study was done in 100 patients who belonged to ASA grade I & II with age of 20-60 years and underwent elective infraumbilical surgeries. After thorough aseptic precaution, L1-L2 or L2-L3 space located and using a 16 gauge Huber point Tuohy needle, epidural space was identified with loss of resistance technique. Through the epidural catheter, a test dose of 2 mL of 1% lignocaine with 10 micrograms of adrenaline was injected and finally the total dose of 15 mL of 0.5% bupivacaine with injection nalbuphine was injected through the catheter and the patients were positioned for the surgery. The pulse rate, blood pressure, respiratory rate were monitored every 5 minutes. Continuous oxygen saturation monitoring was done. At the end of surgery, patients were observed in the recovery room and in the postoperative ward. The level of consciousness assessed ever ½ hour and graded according to the sedation score. Patients were asked to mark a point scale on the 10-point visual analogue scale of pain according to the intensity of pain. The observation was done every 30 minutes. The pain relief is graded according to VAPS. OBSERVATION AND RESULTSPatients in both groups were comparable in age, duration, the site and type of surgery and baseline parameters at the starting of procedure. There were statistically no significant differences between mean age distribution, surgery performed, duration of procedure and baseline parameters in both groups. In this study, rapid onset in group A patients is due to synergistic effect of nalbuphine and bupivacaine. In case of time of onset of motor block, the actual difference between the mean is 5.04 -the study is significant (P<0.000). In the group A, the regression time was the range of 60-83 minutes with the minimum VAPS was 1 and maximum 3. Hence, the quality of analgesia was fair in 30 (85.7%) patients and good in 5 (14.3%). In the group B, the regression time was the range of 54-84 minutes and the quality of analgesia was not assessed since all of them received postoperative narcotic supplementation after the surgery. Hence, the mean duration of surgery was 61.48 minutes, and 63 minutes in Group B. In Group A, patients had sedation score with mean of 0.46 (p value 0.000) which is statically significant. In Group B, all patients were awake. There is significance in BP maintenance in group A, whereas in group B it falls below the baseline value after 5 minutes and 15 minutes and then raises after 30 min. and 45 minutes. No hypotension occurred in group A and in group B. CONCLUSIONIn our study, the epidural nalbuphine hastens the onset of both sensory and motor blockade and significantly prolonged the duration of ...

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Chloroprocaine Antagonism of Epidural Opioid Analgesia

Cited by 38 publications

References 0 publications

Intrathecal fentanyl-induced pruritus is more severe in combination with procaine than with lidocaine or bupivacaine

Intrathecal fentanyl-induced pruritus is more severe in combination with procaine than with lidocaine or bupivacaine

Epidural nalbuphine for analgesia following caesarean delivery: dose-response and effect of local anaesthetic choice

A Comparative Study of Epidural Nalbuphine With Bupivacaine vs. Bupivacaine Alone in Infraumbilical Surgeries

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