Chloroquine-associated pruritus in a European.

Spencer, Harrison C.; Poulter, NR; Lury, J.D; Poulter, Caroline

doi:10.1136/bmj.285.6356.1703

Cited by 22 publications

(16 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This type of pruritus has been considered as severe in almost 60% of pruritic subjects (62)(63)(64). Interestingly, chloroquine-induced pruritus is uncommon in Caucasian or Asian people (65,66). In the study by Bussaratid et al (65) among Thailand's population only 1.9% of over 1000 malaria patients experienced pruritus due to chloroquine therapy.…”

Section: Pruritus Induced By Chloroquine and Other Antimalarialsmentioning

confidence: 93%

Drug-induced Pruritus: A Review

Reich¹,

Ständer²,

Szepietowski³

2009

Acta Derm Venerol

138

View full text Add to dashboard Cite

Pruritus is an unpleasant sensation that leads to scratching. In addition to several diseases, the administration of drugs may induce pruritus. It is estimated that pruritus accounts for approximately 5% of all skin adverse reactions after drug intake. However, to date there has been no systematic review of the natural course and possible underlying mechanisms of drug-induced pruritus. For example, no clear distinction has been made between acute or chronic (lasting more than 6 weeks) forms of pruritus. This review presents a systematic categorization of the different forms of drug-induced pruritus, with special emphasis on a therapeutic approach to this side-effect.

show abstract

Section: Pruritus Induced By Chloroquine and Other Antimalarialsmentioning

confidence: 93%

Drug-induced Pruritus: A Review

Reich¹,

Ständer²,

Szepietowski³

2009

Acta Derm Venerol

138

View full text Add to dashboard Cite

show abstract

“…Most black Africans have a severe itch reaction to chloroquine, and this reaction can be so severe that many patients even refuse to take chloroquine to treat their malaria (Olatunde 1977;Abila et al 1989;Mnyika and Kihamia 1991;Ademowo et al 1998); interestingly, other races do not have such an itch response to chloroquine (Sams and Epstein 1965;Spencer et al 1982). Because patients experience itch when they first ingest chloroquine and because antihistamines do not effectively prevent this side effect, researchers in Africa concluded that chloroquine-induced itch is not an allergic response, nor is it mediated by histamine receptors (Abila et al 1994).…”

Section: Mrgpra3mentioning

confidence: 97%

The Role of the Mrgpr Receptor Family in Itch

Q¹,

Dong

2015

Handbook of Experimental Pharmacology

View full text Add to dashboard Cite

Itch is a complex sensory modality that can be evoked by an extremely diverse set of stimuli and has multiple components of disease etiology. Thus, determining the basic molecular and cellular players is essential before we can tackle the more complex aspects of itch. The identification of novel itch receptors has been extremely fruitful and has uncovered novel signaling pathways and pruritogens. Mrgprs encode a family of G protein-coupled receptors, many of which are expressed specifically in sensory nerves and function as itch receptors in mediating histamine-independent itch. In this chapter, we will review the discovery of the receptor family, their specific expression, their roles as itch receptors, and the itch-inducing agonists. Furthermore, we will summarize the results indicating that Mrgpr-expressing sensory neurons are itch-sensing neurons. In the end we will discuss the role of Mrgprs and Mrgpr-positive neurons in chronic itch.

show abstract

“…Research on chloroquine‐induced itch has been performed without a control group and without a validated itch assessment tool or a visual analog scale. Nonetheless, this is a very interesting phenomenon as, to our knowledge, only one case of chloroquine‐induced pruritus in a Caucasian individual has been reported previously 47 . Recent fundamental research has demonstrated the existence of a specific subset of TRPV‐1 receptors which, upon activation, are strongly associated with itch response in mice.…”

Section: Discussionmentioning

confidence: 94%

“…Nonetheless, this is a very interesting phenomenon as, to our knowledge, only one case of chloroquine-induced pruritus in a Caucasian individual has been reported previously. 47 Recent fundamental research has demonstrated the existence of a specific subset of TRPV-1 receptors which, upon activation, are strongly associated with itch response in mice. They can be activated not only by histamine but also by chloroquine.…”

Section: Discussionmentioning

confidence: 99%