2020
DOI: 10.1038/s41586-020-2575-3
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Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2

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Cited by 410 publications
(426 citation statements)
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“…We have shown in this study that the protease inhibitor, camostat, is highly efficient at blocking SARS-CoV-2 replication in human airway cells and we note that clinical trials are ongoing [ClinicalTrials.gov Identifier: NCT04455815]. Our study also confirms the limitations of relying on Vero E6 cells as a system for developing classes of drugs such as entry inhibitors as they do not accurately reflect the preferred entry mechanism of SARS-CoV-2 into human airway cells (Hoffmann, Mosbauer, et al, 2020; T. Ou et al, 2020).…”
Section: Discussionmentioning
confidence: 50%
“…We have shown in this study that the protease inhibitor, camostat, is highly efficient at blocking SARS-CoV-2 replication in human airway cells and we note that clinical trials are ongoing [ClinicalTrials.gov Identifier: NCT04455815]. Our study also confirms the limitations of relying on Vero E6 cells as a system for developing classes of drugs such as entry inhibitors as they do not accurately reflect the preferred entry mechanism of SARS-CoV-2 into human airway cells (Hoffmann, Mosbauer, et al, 2020; T. Ou et al, 2020).…”
Section: Discussionmentioning
confidence: 50%
“…However, recent work shows that Vero E6 cells do not express TMPRSS2, and instead viral entry is achieved through an alternative and CQ-inhibited pathway . 23 Thus, BHX may show benefits in cells where SARS-CoV-2 entry depends on TMPRSS2.…”
Section: Discussionmentioning
confidence: 99%
“…These results suggest that IFITM3 may have opposing effects on SARS-CoV-2 depending on the cellular location at which the virus fusion process occurs. Interestingly, IFITMs may have a proviral effect on SARS-CoV-2 infection of lung epithelial cells (Prelli Bozzo et al, 2020), which are infected primarily via plasma membrane fusion as opposed to endosomal fusion (Hoffmann, Kleine-Weber, et al, 2020a;Hoffmann, Mösbauer, et al, 2020b). As this potentially proviral effect is unique to coronaviruses, a mechanistic understanding of the activity of IFITMs will be key in delineating their roles in coronavirus infections.…”
mentioning
confidence: 99%