2015
DOI: 10.7314/apjcp.2015.16.5.2031
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Chloroquine Exerts Anti-metastatic Activities Under Hypoxic Conditions in Cholangiocarcinoma Cells

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Cited by 13 publications
(6 citation statements)
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“…Regarding CQ, its IC 50 for inhibition of CCA cell proliferation is comparable to those of other cancer cells (27)(28)(29)(30). CQ is known to inhibit metastatic activity of CCA-cells under hypoxic condition (31). Our results added the information that CQ also can inhibit proliferation of highly metastatic CCA-cells under normoxic condition.…”
Section: Discussionsupporting
confidence: 64%
“…Regarding CQ, its IC 50 for inhibition of CCA cell proliferation is comparable to those of other cancer cells (27)(28)(29)(30). CQ is known to inhibit metastatic activity of CCA-cells under hypoxic condition (31). Our results added the information that CQ also can inhibit proliferation of highly metastatic CCA-cells under normoxic condition.…”
Section: Discussionsupporting
confidence: 64%
“…CQ can inhibit hypoxia-stimulated metastasis via modulation of hypoxia-inducible factor 1α (HIF-1α), vascular endothelial growth factor (VEGF), and epithelial mesenchymal transition (EMT) as shown in a cholangiocarcinoma cell line [ 105 ].…”
Section: Mechanism Of Actionmentioning
confidence: 99%
“…Consistently, in vitro studies clearly demonstrated that hypoxia-induced signaling led CCA cells to gain a more malignant phenotype. For instance, low-oxygen culture conditions, as well as treatment with cobalt chloride (i.e., a chemical inducer of HIF-1α), promoted a substantial increase in CCA cell motility and invasiveness [190,191]. In a recent study the authors found that the hepatocyte growth factor (HGF) antagonist NK4 is effective on inhibiting CCA cell hypoxic growth and invasion both in vitro and in vivo.…”
Section: Hif-1α Signaling Pathwaymentioning
confidence: 99%